Iowa Cochlear Implant Clinical Research Center VII

项目主任/首席调查员(最后、第一、中间)：甘茨，布鲁斯·J 项目摘要-概述 听力损失是一个普遍存在的问题，根据NIDCD/NIH网站的统计数据，据估计 它影响了近3750万18岁及以上的美国人。在使用助听器和 人工耳蜗植入物已经帮助了那些中度到重度损失的人，噪音干扰了他们的能力 能听懂语言。我们的研究已经确定了声电结合的重要优势 语音处理(A+E)，以提高噪声中的听力。A+E工艺的应用有了改进 安静和噪声条件下人工耳蜗术后的预后，但预后存在显著的个体差异 受试者之间的测量。为了解决这些问题，这项申请要求爱荷华州继续 人工耳蜗术临床研究中心。在这个提案中，我们将研究听觉和听觉感知 使用探索来自听觉外周的电、声和A+E听力机制的研究 到大脑皮层，包括大脑皮层(重组)和高级语言处理的测量。同样 重要的是，我们还探索了人类生态--人和环境中的因素，可以调节或 妨碍成功交流，并可通过A+E语音处理进行修改。我们的首要目标是 这一竞争更新是应用基础和认知神经科学方法来帮助我们解决 这些关于个人如何使用声学和电听信息的基本问题。四 研究项目，人类生态学，外周电生理学，中枢听觉整合和认知 提出了语言处理的动态化、行政和病人护理/技术支持的核心。 总体目标是考察A+E处理功能对现实社会化的影响， 认知和生活质量问题，并评估从外围到皮质和大脑的听觉处理 更高级别的处理。我们计划研究200名新植入的成年受试者，这些受试者保持A+E听力 植入物，50名使用助听器的受试者，50名正常听力受试者，以及之前300名的组合 植入了A+E、双峰或单CI的受试者，这些受试者参与了我们的研究登记。四项研究 项目是高度集成的，并依赖于彼此的数据来回答实验问题 建议。

Program Director/Principal Investigator (Last, First, Middle): Gantz, Bruce J. PROJECT SUMMARY - OVERVIEW Hearing loss is a pervasive problem and, according to statistics from the NIDCD/NIH website, it is estimated that it affects nearly 37.5 million Americans aged 18 years and older. While remediation with hearing aids and cochlear implants has assisted those with moderate to profound loss, noise interferes with the ability to understand speech. Our research has identified the important advantage of combining acoustic+electric speech processing (A+E) to facilitate improved hearing in noise. Application of A+E processing has improved outcomes of cochlear implants in quiet and noise, but there is significant individual variability in outcome measures among subjects. To address these issues, this application requests continuation of the Iowa Cochlear Implant Clinical Research Center. In this proposal we will investigate hearing and auditory perception using studies that explore the mechanisms of electrical, acoustic, and A+E hearing from the auditory periphery to the cortex, including measures of cortical (re)organization and higher order language processing. Equally important, we also explore human ecology—factors in the person and in the environment that can mediate or impede successful communication and can be modified by A+E speech processing. Our overarching goal of this competitive renewal is to apply basic and cognitive neuroscience methodologies to assist us in addressing these fundamental questions about how individuals use both acoustic and electric auditory information. Four research projects, Human Ecology, Peripheral Electrophysiology, Central Auditory Integration and Cognitive Dynamics of Language Processing, an administrative and patient care/technical support cores are proposed. The overall objectives are to examine the impact that A+E processing function has on real-life socialization, cognition and quality of life issues, and to evaluate auditory processing from the periphery to cortical and higher level processing. We plan to study 200 newly implanted adult subjects with A+E hearing preservation implants, 50 subjects that use a hearing aid, 50 normal hearing subjects, and a combination of 300 previously implanted subjects with A+E, bimodal or single CIs that participate in our research registry. The four research projects are highly integrated and depend on data from each other to answer the experimental questions proposed.