Hemoglobin Switching Meeting

摘要 两年一度的血红蛋白转换大会已经持续了43年，有多个 它之所以取得巨大的、持续的成功。首先也是最重要的，组织者希格斯、恩格尔、佐恩和 Sankaran努力通过总是包括新的、年轻的调查人员来识别并突出新的发现 以及对珠蛋白生物合成过程的影响的研究。第二，这是唯一的会场(除了 有超过25,000人参加的ASH年度会议)，将基础科学家和临床医生聚集在一起 讨论血红蛋白疾病的分子和发育起源以及治疗方法 人类最常见的遗传性疾病。第三，从历史上看，这些会议的重点是 无论科学引领到哪里，因此仍然是非常热门的，并且不仅是展示 第一个cdna克隆，第一个克隆的人类基因组位点(及其第一个突变)，其结构 促红细胞生成素和GATA和KLF转录因子家族的发现，但它也推出了 这一领域的许多现任领导者的职业生涯(事实上，许多前博士后研究员和现任 在这次会议上，教员们首先在全体会议上介绍了他们的工作)。第四，这是唯一一次关于这个问题的会议 这一话题通常得到来自美国国内外调查人员的大致相同的参与， 这一事实从美国和欧洲两年一次的会议地点交替中得到了反映。2020年 会议将在希腊克里特岛举行。

Abstract The biennial Hemoglobin Switching Conferences have been ongoing for 43 years, and there are multiple reasons for its resounding, continued success. First and foremost, the organizers Higgs, Engel, Zon and Sankaran strive to identify and then highlight new discoveries by always including new, young investigators and studies that impinge on the process of globin biosynthesis. Second, this is the only venue (other than the annual ASH meeting, with more than 25,000 participants) that brings together basic scientists and clinicians to discuss both the molecular and developmental origins of, and treatments for, the hemoglobinopathies, the most common inherited diseases in man. Third, the meetings have historically evolved with intense focus on wherever the science led, thus remaining extremely topical, and has not only been the forum for presenting the first cDNA clones, the first cloned human genomic locus (and the first mutations in same), the structure of erythropoietin and the discovery of the GATA and KLF transcription factor families, but it has also launched the careers of many of the current leaders in this field (indeed, numerous former postdoctoral fellows and current faculty first presented their work in plenary sessions at this conference). Fourth, this is the only meeting on this topic that routinely has approximately equal attendance by investigators from both inside and outside the U.S., and this fact is reflected by the biennial alternation in conference site between the U.S. and Europe. In 2020 the Conference will be held in Crete, Greece.