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Hemoglobin Switching Meeting

血红蛋白转换会议

基本信息

批准号：
10064453
负责人：
LEONARD Ira ZON
金额：
$ 1万
依托单位：
BOSTON CHILDREN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-01 至 2022-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10064453
关键词：
American Society of Hematology Anabolism Back Biochemical Biochemistry Carbon Dioxide Cell Differentiation process Cells Cellular biology Clinical Collaborations Complementary DNA Crete Development Developmental Biology Disease Epigenetic Process Erythrocytes Erythropoietin Etiology Europe Faculty Family Fertilization Gene Expression Regulation Genes Genetic Genetic Diseases Genomics Globin Greece Hematology Hematopoietic Hemoglobin Hemoglobinopathies Hereditary Disease Human Cloning Human Genetics Inherited International Lung Metabolic Diseases Metabolism Minority Molecular Molecular Biology Mutation Oxygen Participant Physiology Postdoctoral Fellow Process Research Research Personnel Science Scientist Sickle Cell Anemia Site Structure Students Therapeutic Clinical Trial Tissues Woman Work beta Thalassemia career disease phenotype drug development effective therapy gene therapy genomic locus man meetings novel phenomenological models stem cells success symposium therapy development transcription factor

项目摘要

Abstract The biennial Hemoglobin Switching Conferences have been ongoing for 43 years, and there are multiple reasons for its resounding, continued success. First and foremost, the organizers Higgs, Engel, Zon and Sankaran strive to identify and then highlight new discoveries by always including new, young investigators and studies that impinge on the process of globin biosynthesis. Second, this is the only venue (other than the annual ASH meeting, with more than 25,000 participants) that brings together basic scientists and clinicians to discuss both the molecular and developmental origins of, and treatments for, the hemoglobinopathies, the most common inherited diseases in man. Third, the meetings have historically evolved with intense focus on wherever the science led, thus remaining extremely topical, and has not only been the forum for presenting the first cDNA clones, the first cloned human genomic locus (and the first mutations in same), the structure of erythropoietin and the discovery of the GATA and KLF transcription factor families, but it has also launched the careers of many of the current leaders in this field (indeed, numerous former postdoctoral fellows and current faculty first presented their work in plenary sessions at this conference). Fourth, this is the only meeting on this topic that routinely has approximately equal attendance by investigators from both inside and outside the U.S., and this fact is reflected by the biennial alternation in conference site between the U.S. and Europe. In 2020 the Conference will be held in Crete, Greece.

摘要