Hemoglobin Switching Meeting

摘要 两年一度的血红蛋白转换会议已经持续了43年，有多个 原因是它的响亮，持续的成功。首先，组织者希格斯，恩格尔，Zon和 Sankaran努力通过总是包括新的年轻研究人员来识别并突出新的发现 以及对珠蛋白生物合成过程的研究。第二，这是唯一的场地（除了 年度ASH会议，有25，000多名与会者），汇集了基础科学家和临床医生， 讨论血红蛋白病的分子和发育起源以及治疗方法， 人类最常见的遗传性疾病。第三，会议历来都在不断发展，重点关注 无论在哪里，科学引领，因此仍然非常热门，不仅是展示 第一个cDNA克隆，第一个克隆的人基因组基因座（和其中的第一个突变）， 促红细胞生成素和加塔和KLF转录因子家族的发现，但它也启动了 职业生涯的许多目前的领导人在这一领域（事实上，许多前博士后研究员和目前 在这次会议的全体会议上首次介绍了他们的工作）。第四，这是唯一一次关于这个问题的会议， 这个话题通常有来自美国内外的调查人员参加， 美国和欧洲每两年更换一次会议地点就反映了这一事实。2020年 会议将在希腊克里特岛举行。

Abstract The biennial Hemoglobin Switching Conferences have been ongoing for 43 years, and there are multiple reasons for its resounding, continued success. First and foremost, the organizers Higgs, Engel, Zon and Sankaran strive to identify and then highlight new discoveries by always including new, young investigators and studies that impinge on the process of globin biosynthesis. Second, this is the only venue (other than the annual ASH meeting, with more than 25,000 participants) that brings together basic scientists and clinicians to discuss both the molecular and developmental origins of, and treatments for, the hemoglobinopathies, the most common inherited diseases in man. Third, the meetings have historically evolved with intense focus on wherever the science led, thus remaining extremely topical, and has not only been the forum for presenting the first cDNA clones, the first cloned human genomic locus (and the first mutations in same), the structure of erythropoietin and the discovery of the GATA and KLF transcription factor families, but it has also launched the careers of many of the current leaders in this field (indeed, numerous former postdoctoral fellows and current faculty first presented their work in plenary sessions at this conference). Fourth, this is the only meeting on this topic that routinely has approximately equal attendance by investigators from both inside and outside the U.S., and this fact is reflected by the biennial alternation in conference site between the U.S. and Europe. In 2020 the Conference will be held in Crete, Greece.