Form-Function Relationships in Femoroacetabular Impingement Syndrome

股骨髋臼撞击综合征的形态与功能关系

• 批准号: 10066165
• 负责人: Joseph Mozingo
• 金额: $ 6.72万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-17 至 2023-08-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10066165
• 关键词: 3-Dimensional; Achievement; Address; Anatomy; Biomechanics; Cartilage; Clinic; Clinical; Clinical Treatment; Cluster Analysis; Collaborations; Computational Technique; Consensus; Control Groups; Cross-Sectional Studies; Data; Decision Making; Deformity; Degenerative polyarthritis; Development; Diagnosis; Diagnostic; Diagnostic radiologic examination; Discipline; Disease; Drops; Ensure; Etiology; Exhibits; Fellowship; Femur; Film; Foundations; Functional disorder; Funding; Future; General Population; Goals; Head; High Prevalence; Hip Osteoarthritis; Hip Pain; Hip region structure; Image; Individual; Institutes; Joints; Knowledge; Lead; Learning; Left; MRI Scans; Magnetic Resonance Imaging; Measurement; Measures; Mechanics; Medical Imaging; Mentors; Mentorship; Methods; Modeling; Morphology; Motion; Motivation; Musculoskeletal; Neck; Orthopedics; Outcomes Research; Pain; Pathology; Patients; Pelvis; Phenotype; Physical therapy; Population; Positioning Attribute; Publications; Recording of previous events; Reporting; Research; Research Personnel; Risk; Running; Severity of illness; Shapes; Slice; Structure; Subgroup; Surface; Symptoms; Syndrome; Techniques; Training; Universities; Utah; Walking; X-Ray Computed Tomography; acetabulum; base; bone; career; clinical care; cohort; educational atmosphere; experience; improved; innovation; kinematics; multidimensional data; pathomechanics; research clinical testing; scientific computing; skills; subchondral bone; success; synergism; theories; therapy development; tool; trait

PROJECT SUMMARY/ABSTRACT By some estimates, femoroacetabular impingement syndrome (FAIS) accounts for 82% of hip osteoarthritis cases. Patients present with loss of femoral head sphericity, reduction in femoral-neck offset, and/or an excessively prominent acetabular wall, and report position- or motion-related pain. The theory of FAIS pathophysiology is that pathoanatomy causes pathomechanics. However, quantitative understanding of this disease is lacking. Few investigators have analyzed the relationship between hip anatomy and biomechanics in FAIS patients; those that have relied on 2D measures that incompletely describe hip shape. Based on these 2D shape metrics, ~35% of the general population carries a ‘silent’ form of the disease, which has hindered progress to understand why FAI morphology causes damage. To advance understanding of FAIS pathophysiology, a cross-sectional study of FAIS patients and controls will be performed. Aim 1 will quantify pathomorphology of FAIS. Hip anatomy will be visualized and compared using statistical shape modeling (SSM). Notably, SSM compares shape over the 3D continuum, rather than relative to a single, 2D image. The central hypothesize is that SSM will detect differences in 3D shape of symptomatic and asymptomatic hips; further, this difference will occur whether controls are analyzed together or as anatomic subgroups identified via cluster analysis. Aim 1 will improve clinical understanding of this disease and inform development of better techniques to evaluate hip anatomy. Aim 2 will quantify pathokinematics of FAIS. Hip motion will be measured during functional activities in FAIS patients and controls. The central hypothesis is that hip kinematics will differ between FAIS patients and controls and that significant relationships exist between hip shape and hip kinematics; further, controls with hip shape similar to FAIS patients will have altered kinematics compared to controls that do not. Aim 2 will guide development of treatment options through a better understanding of compensatory mechanisms that occur across groups. The training plan is tailored to facilitate achievement of the applicant’s career goals through development of scientific and professional skills and opportunities to generate and disseminate research findings. The training plan enables collaboration between the applicant and sponsors in the University of Utah Departments of Orthopaedics and Physical Therapy, and Scientific Computing and Imaging Institute. The sponsor team (Drs. Andrew Anderson (primary mentor), Shireen Elhabian, Kenneth “Bo” Foreman, Stephen Aoki) is well-qualified to train the applicant in computational biomechanics, analysis techniques for high-dimensional data, motion analysis, and clinical treatment of hip pathology. The sponsor team has a strong history of successful collaboration, mentorship, publication, and funding. Receipt of an F32 fellowship will enhance synergy between the applicant and sponsors, enable the applicant to take full advantage of the strong research, clinical, and educational environment at the University of Utah, and ensure the applicant success in becoming an independent, impactful researcher.

项目摘要/摘要 据某些估计，股骨替代障碍综合征（FAI）占髋关节骨关节炎的82％ 案例。患者出现股骨头球的丧失，股骨颈偏移的减少和/或 过度突出的髋臼壁，并报告位置或运动相关的疼痛。粪便理论 病理生理学是病原体会导致致病力学。但是，对此的定量理解 疾病缺乏。很少有研究人员分析了髋部解剖与生物力学之间的关系 在FAIS患者中；那些对不完全描述髋关节形状的2D度量缓解的人。基于这些 2D形状指标，约35％的普通人群具有“沉默”形式，这种疾病已阻碍 进步以了解为什么FAI形态会造成损害。促进对粪便的理解 病理生理学，将对FAIS患者和对照组进行横断面研究。 AIM 1将量化 FAI的病原体。将使用统计形状建模对髋关节解剖结构进行可视化和比较 （SSM）。值得注意的是，SSM比较了3D连续体上的形状，而不是相对于单个2D图像。这 中心假设是SSM将检测症状和渐进臀部的3D形状差异。 此外，无论将控件分析在一起还是作为确定的解剖亚组，将发生这种差异 通过聚类分析。 AIM 1将改善对该疾病的临床理解，并为发展提供信息 评估髋关节解剖的技术。 AIM 2将量化FAI的病变。髋部运动将测量 在FAIS患者和对照组中的功能活动中。中心假设是髋部运动学会有所不同 FAIS患者与对照组之间以及臀部形状和髋关节之间存在显着关系 运动学；此外，与FAIS患者类似的髋部形状对照与相比将改变运动学 没有的控件。 AIM 2将通过更好地理解治疗方案的开发 跨组发生的补偿机制。培训计划是为了促进实现的量身定制的 申请人通过发展科学和专业技能和机会来实现职业目标 产生并传播研究结果。该培训计划使申请人与 犹他大学骨科和物理疗法的赞助商以及科学疗法 计算和成像研究所。赞助商团队（Drs。AndrewAnderson（主要导师），Shireen Elhabian，Kenneth“ Bo” Foreman，Stephen Aoki）非常合格地培训申请人的计算 生物力学，高维数据的分析技术，运动分析和髋关节治疗 病理。赞助商团队拥有成功的合作，指导，出版和 资金。 F32奖学金的接收将增强申请人和赞助商之间的协同作用，启用 申请人充分利用大学的强大研究，临床和教育环境 犹他州，并确保成为一名独立，有影响力的研究人员的适用成功。