Form-Function Relationships in Femoroacetabular Impingement Syndrome

股骨髋臼撞击综合征的形态与功能关系

• 批准号: 10460516
• 负责人: Joseph Mozingo
• 金额: $ 4.44万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-17 至 2023-03-10
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10460516
• 关键词: 3-Dimensional; Achievement; Address; Anatomy; Biomechanics; Cartilage; Clinic; Clinical; Clinical Treatment; Cluster Analysis; Collaborations; Computational Technique; Consensus; Control Groups; Cross-Sectional Studies; Data; Decision Making; Deformity; Degenerative polyarthritis; Development; Diagnosis; Discipline; Disease; Drops; Ensure; Etiology; Exhibits; Fellowship; Femur; Film; Foundations; Functional disorder; Funding; Future; General Population; Goals; Head; High Prevalence; Hip Osteoarthritis; Hip Pain; Hip region structure; Image; Individual; Institutes; Joints; Knowledge; Lead; Learning; Left; MRI Scans; Magnetic Resonance Imaging; Measurement; Measures; Mechanics; Medical Imaging; Mentors; Mentorship; Methods; Modeling; Morphology; Motion; Motivation; Musculoskeletal; Neck; Orthopedics; Outcomes Research; Pain; Pathology; Patients; Pelvis; Phenotype; Physical therapy; Population; Positioning Attribute; Publications; Recording of previous events; Reporting; Research; Research Personnel; Risk; Running; Severity of illness; Shapes; Slice; Subgroup; Surface; Symptoms; Syndrome; Techniques; Training; Universities; Utah; Walking; X-Ray Computed Tomography; acetabulum; base; biomechanical test; bone; career; clinical care; cohort; diagnostic tool; educational atmosphere; experience; improved; innovation; kinematics; multidimensional data; pathomechanics; radiological imaging; research clinical testing; scientific computing; skills; subchondral bone; success; synergism; theories; therapy development; trait

PROJECT SUMMARY/ABSTRACT By some estimates, femoroacetabular impingement syndrome (FAIS) accounts for 82% of hip osteoarthritis cases. Patients present with loss of femoral head sphericity, reduction in femoral-neck offset, and/or an excessively prominent acetabular wall, and report position- or motion-related pain. The theory of FAIS pathophysiology is that pathoanatomy causes pathomechanics. However, quantitative understanding of this disease is lacking. Few investigators have analyzed the relationship between hip anatomy and biomechanics in FAIS patients; those that have relied on 2D measures that incompletely describe hip shape. Based on these 2D shape metrics, ~35% of the general population carries a ‘silent’ form of the disease, which has hindered progress to understand why FAI morphology causes damage. To advance understanding of FAIS pathophysiology, a cross-sectional study of FAIS patients and controls will be performed. Aim 1 will quantify pathomorphology of FAIS. Hip anatomy will be visualized and compared using statistical shape modeling (SSM). Notably, SSM compares shape over the 3D continuum, rather than relative to a single, 2D image. The central hypothesize is that SSM will detect differences in 3D shape of symptomatic and asymptomatic hips; further, this difference will occur whether controls are analyzed together or as anatomic subgroups identified via cluster analysis. Aim 1 will improve clinical understanding of this disease and inform development of better techniques to evaluate hip anatomy. Aim 2 will quantify pathokinematics of FAIS. Hip motion will be measured during functional activities in FAIS patients and controls. The central hypothesis is that hip kinematics will differ between FAIS patients and controls and that significant relationships exist between hip shape and hip kinematics; further, controls with hip shape similar to FAIS patients will have altered kinematics compared to controls that do not. Aim 2 will guide development of treatment options through a better understanding of compensatory mechanisms that occur across groups. The training plan is tailored to facilitate achievement of the applicant’s career goals through development of scientific and professional skills and opportunities to generate and disseminate research findings. The training plan enables collaboration between the applicant and sponsors in the University of Utah Departments of Orthopaedics and Physical Therapy, and Scientific Computing and Imaging Institute. The sponsor team (Drs. Andrew Anderson (primary mentor), Shireen Elhabian, Kenneth “Bo” Foreman, Stephen Aoki) is well-qualified to train the applicant in computational biomechanics, analysis techniques for high-dimensional data, motion analysis, and clinical treatment of hip pathology. The sponsor team has a strong history of successful collaboration, mentorship, publication, and funding. Receipt of an F32 fellowship will enhance synergy between the applicant and sponsors, enable the applicant to take full advantage of the strong research, clinical, and educational environment at the University of Utah, and ensure the applicant success in becoming an independent, impactful researcher.

项目总结/摘要 据估计，股骨髋臼撞击综合征（FAIS）占髋关节骨关节炎的82 例患者存在股骨头球形度丧失、股骨颈偏心距减小和/或 髋臼壁过度突出，并报告位置或运动相关疼痛。FAIS理论 病理生理学是病理解剖学导致病理力学。然而，对这一点的定量理解 疾病缺乏。很少有研究者分析髋关节解剖学和生物力学之间的关系 在FAIS患者中;那些依赖于不完全描述髋关节形状的2D测量的患者。基于这些 根据2D形状指标，约35%的普通人群携带“沉默”形式的疾病，这阻碍了 进一步了解FAI形态学导致损伤的原因。促进对FAIS的理解 在病理生理学方面，将进行FAIS患者和对照的横断面研究。目标1将量化 FAIS的病理形态学将使用统计形状建模对髋关节解剖结构进行可视化和比较 （SSM）。值得注意的是，SSM在3D连续体上比较形状，而不是相对于单个2D图像。的 中心假设是SSM将检测有症状和无症状髋关节的3D形状差异; 此外，无论对照组是一起分析还是作为解剖亚组进行分析，都会出现这种差异 通过聚类分析。目的1将提高对这种疾病的临床认识，并为更好地开发 评估髋关节解剖结构的技术。目的2将量化FAIS的病理运动学。将测量髋关节活动度 在FAIS患者和对照组的功能活动中。中心假设是，髋关节运动学将不同 FAIS患者和对照组之间存在显著的相关性，髋关节形状和髋关节功能之间存在显著的相关性。 运动学;此外，与FAIS患者相比，髋关节形状类似的对照组将具有改变的运动学。 控制不。目标2将通过更好地了解以下方面来指导治疗方案的制定： 补偿机制是跨群体发生的。培训计划是专门为促进实现 申请人的职业目标，通过科学和专业技能的发展和机会， 产生和传播研究成果。培训计划使申请人和 犹他州大学骨科和物理治疗系的赞助商， 计算机和成像研究所。申办者团队（Andrew安德森博士（主要导师）、Shireen Elhabian，Kenneth“Bo”Foreman，Stephen Aoki）非常有资格在计算方面培训申请人 生物力学、高维数据分析技术、运动分析和髋关节临床治疗 病理赞助商团队有着成功的合作，指导，出版和 经费获得F32奖学金将加强申请人和赞助商之间的协同作用， 申请人充分利用大学强大的研究，临床和教育环境 的犹他州，并确保申请人成功成为一个独立的，有影响力的研究人员。

项目成果

Prediction of femoral head coverage from articulated statistical shape models of patients with developmental dysplasia of the hip.

• DOI: 10.1002/jor.25227
• 发表时间: 2022-09
• 期刊: JOURNAL OF ORTHOPAEDIC RESEARCH
• 影响因子: 2.8
• 作者: Atkins, Penny R.;Agrawal, Praful;Mozingo, Joseph D.;Uemura, Keisuke;Tokunaga, Kunihiko;Peters, Christopher L.;Elhabian, Shireen Y.;Whitaker, Ross T.;Anderson, Andrew E.
• 通讯作者: Anderson, Andrew E.