Neurocognitive effects of iron deficiency in blood donors.

献血者缺铁对神经认知的影响。

• 批准号: 10065515
• 负责人: Eldad Arie Hod
• 金额: $ 59.01万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-12-15 至 2021-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10065515
• 关键词: Address; Affect; Aging; Altruism; Ancillary Study; Attention; Basal Ganglia; Biochemistry; Blinded; Blood; Blood Donations; Blood donor; Brain; Brain region; Cell physiology; Clinical; Deposition; Development; Double-Blind Method; Episodic memory; Erythrocytes; Evaluation; Frequencies; Functional Magnetic Resonance Imaging; Funding; Goals; Guidelines; Health; Hour; Individual; Intravenous; Iron; Iron-Dextran Complex; Knowledge; Laboratories; Learning; Link; Magnetic Resonance Imaging; Measurable; Measures; Memory; Metals; Methods; Minor; Mitochondria; Modeling; Molecular Weight; Monitor; Motor; Neostriatum; Nervous System Physiology; Neurocognition; Neurocognitive; Neurologic; Neurons; Neurotransmitters; Parents; Parietal; Pattern; Performance; Personal Satisfaction; Placebos; Policies; Predisposition; Randomized; Recovery; Research; Rest; Saline; Sensory; Signal Transduction; Structure; Testing; Time; Transfusion; United States; United States National Institutes of Health; Visual; Whole Blood; Woman; blood oxygen level dependent; design; double-blind placebo controlled trial; executive function; improved; improved functioning; insight; iron deficiency; iron supplementation; men; myelination; neural network; neurocognitive test; nigrostriatal pathway; parent project; performance tests; primary outcome; processing speed; prospective; recruit; volunteer

The overall goal of this ancillary study is to determine if iron deficiency in frequent whole blood donors adversely affects their neurocognitive function. Over 15 million red blood cell units are donated annually in the United States. Despite fulfilling all requirements for blood donation, almost two-thirds of the women, and half of the men, who are regular blood donors are iron deficient. The overall intent of this study is to develop a chain of evidence linking iron repletion in iron-deficient donors to (i) increases of iron in specific brain structures to (ii) improved processing speed and memory with improved efficiency and connectivity in related functional networks by functional MRI to (iii) improved performance on neurocognitive testing. To this end, we will recruit from a prospective, double-blind, randomized, placebo-controlled parent trial of iron-deficient regular blood donors. In Aim #1, we will determine whether iron repletion of iron-deficient blood donors improves neurocognitive test performance. In Aim #2, we will determine whether iron repletion improves processing speed and episodic memory by altering activity and connectivity in specific functional networks at resting state. In Aim #3, we will determine whether iron repletion increases iron concentrations in specific brain structures. The neurocognitive impact of iron deficiency due to frequent blood donation has not been rigorously examined and this critical knowledge gap is addressed by this proposed ancillary study. Completing this study will provide definitive evidence for the presence or absence of iron deficiency-induced neurocognitive and neurological functional deficits in frequent blood donors. Our results will lead to improved policies and practices regarding iron supplementation, iron monitoring, and donation frequency.

这项辅助研究的总体目标是确定频繁的全血献血者是否缺铁

项目成果

A randomized trial of blood donor iron repletion on red cell quality for transfusion and donor cognition and well-being.

一项随机试验，研究献血者补充铁对输血红细胞质量以及献血者认知和健康的影响。

• DOI: 10.1182/blood.2022017288
• 发表时间: 2022
• 期刊: Blood
• 影响因子: 20.3
• 作者: Hod,EldadA;Brittenham,GaryM;Bitan,ZacharyC;Feit,Yona;Gaelen,JordanI;LaCarpia,Francesca;Sandoval,LukeA;Zhou,AliceT;Soffing,Mark;Mintz,Akiva;Schwartz,Joseph;Eng,Connie;Scotto,Marta;Caccappolo,Elise;Habeck,Christian;Stern
• 通讯作者: Stern