Community-directed vector control to enhance mass drug administration for onchocerciasis elimination in Africa
Community-directed vector control to enhance mass drug administration for onchocerciasis elimination in Africa
批准号:
10065489
负责人:
THOMAS R UNNASCH
金额:
$51.96万
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
已结题
起止时间:
2016-12-01 至 2022-11-30
关键词:
AffectAfricaAlgorithmsAreaBlindnessBreedingCharacteristicsCollectionCommunitiesCountryDataDevelopmentDiseaseEntomologyExcisionGoalsGuidelinesHabitatsHumanIndividualInfectionInsecticidesInternationalInterruptionInterventionIntestinal VolvulusIvermectinLarvaLatin AmericaLifeLogisticsLondonManufacturer NameMeasuresMethodsModelingMonitorOcular OnchocerciasisOnchocerca volvulusOnchocerciasisParasitesPathogenicityPharmaceutical PreparationsPlanetsProbabilityProcessPublic HealthRecrudescencesScourgeSimuliidaeSimulium genusSiteStressStudy modelsTestingTimeTrainingUgandabasedensitydisorder controlexperienceexperimental studymathematical modelmemberneglected tropical diseasesprogramsremote sensingsuccesstransmission processtreatment feesvectorvector control
中文摘要
摘要
英文摘要
ABSTRACT
Onchocerciasis, or river blindness, is one of the recognized neglected tropical diseases of mankind. The
disease is caused by the filarial parasite Onchocerca volvulus, which is spread by black flies (Simulium
spp). In the 1980s, ivermectin was first shown to be a potent microfilaricide against O. volvulus. As a
result, international programs were begun to either control or eliminate onchocerciasis, employing a
strategy of mass drug administration (MDA) of ivermectin to afflicted communities. Long term MDA based
programs have resulted in the elimination of onchocerciasis from some foci in Africa and almost all foci in
Latin America. These successes have resulted in a change in focus from a goal of disease control of
onchocerciasis to a goal of elimination, enshrined in the London Declaration on Neglected Tropical
Diseases, which set a goal of eliminating onchocerciasis from Africa by 2020. Despite these successes,
MDA alone will probably not be sufficient to interrupt transmission in many regions of Africa in time to meet
the London Declaration goals, and may not be capable of interrupting transmission at all where vector
densities are high. In such areas, it will be necessary to supplement MDA with other interventions. The
experience of Uganda has demonstrated the power of utilizing a combination of vector control and
ivermectin MDA, which has resulted in the interruption of transmission of O. volvulus in 9 of the country’s
17 foci in just 7 years. However, black fly control has traditionally relied upon insecticide treatment of vector
breeding sites, an approach that is expensive and logistically difficult. Here we propose a different
paradigm for the control of the black fly vectors of O. volvulus, that of involving the afflicted communities in
this process. This project is an outgrowth of recent projects (1) to develop a black fly trap to replace
human landing collections for entomological monitoring of O. volvulus transmission and, (2) to develop a
remote sensing algorithm capable of predicting vector black fly breeding habitats. The first project resulted
in the development of the Esperanza Window Trap (EWT), a platform constructed from locally available
inexpensive materials, which equals or out performs a human landing team for the collection of vector
species. The EWT can be successfully operated by local residents and has been shown to significantly
reduce biting rates. In the second effort, we have conducted preliminary studies that demonstrate that
enlisting local residents to remove trailing vegetation from detected vector breeding sites can reduce local
biting rates by over 80%. The overall hypothesis that will be evaluated in this project through a combination
of field experiments and mathematical modeling studies is that community directed vector control efforts
using optimized traps, local reduction of breeding habitat or some combination of these will reduce vector
biting rates to a point where O. volvulus may be eliminated by co-administration of MDA, even in areas
where vector density is high.
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DOI:
10.1155/2018/5902367
发表时间:
2018
期刊:
Journal of parasitology research
影响因子:
2.2
作者:
[Otabil KB, Gyasi SF, Awuah E, Obeng-Ofori D, Rodríguez-Pérez MA, Katholi CR, Unnasch TR]
通讯作者:
Unnasch TR
Data-driven modelling and spatial complexity supports heterogeneity-based integrative management for eliminating Simulium neavei-transmitted river blindness.
数据驱动的建模和空间复杂性支持基于异质性的综合管理,以消除尼氏蝽传播的河盲症。
DOI:
10.1038/s41598-020-61194-w
发表时间:
2020
期刊:
Scientific reports
影响因子:
4.6
作者:
[Michael,Edwin, Smith,MorganE, Singh,BrajendraK, Katabarwa,MosesN, Byamukama,Edson, Habomugisha,Peace, Lakwo,Thomson, Tukahebwa,Edridah, Richards,FrankO]
通讯作者:
Richards,FrankO
DOI:
10.1093/cid/ciaa933
发表时间:
2021-04-26
期刊:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子:
--
作者:
[Toor J, Adams ER, Aliee M, Amoah B, Anderson RM, Ayabina D, Bailey R, Basáñez MG, Blok DJ, Blumberg S, Borlase A, Rivera RC, Castaño MS, Chitnis N, Coffeng LE, Crump RE, Das A, Davis CN, Davis EL, Deiner MS, Diggle PJ, Fronterre C, Giardina F, Giorgi E, Graham M, Hamley JID, Huang CI, Kura K, Lietman TM, Lucas TCD, Malizia V, Medley GF, Meeyai A, Michael E, Porco TC, Prada JM, Rock KS, Le Rutte EA, Smith ME, Spencer SEF, Stolk WA, Touloupou P, Vasconcelos A, Vegvari C, de Vlas SJ, Walker M, Hollingsworth TD]
通讯作者:
Hollingsworth TD
DOI:
10.1371/journal.pntd.0006702
发表时间:
2018-08
期刊:
PLoS neglected tropical diseases
影响因子:
3.8
作者:
[Jacob BG, Loum D, Lakwo TL, Katholi CR, Habomugisha P, Byamukama E, Tukahebwa E, Cupp EW, Unnasch TR]
通讯作者:
Unnasch TR
Accelerating river blindness elimination by supplementing MDA with a vegetation "slash and clear" vector control strategy: a data-driven modeling analysis.
通过植被“削减和清除”病媒控制策略补充 MDA 来加速消除河盲症:数据驱动的建模分析。
DOI:
10.1038/s41598-019-51835-0
发表时间:
2019
期刊:
Scientific reports
影响因子:
4.6
作者:
[Smith,MorganE, Bilal,Shakir, Lakwo,ThomsonL, Habomugisha,Peace, Tukahebwa,Edridah, Byamukama,Edson, Katabarwa,MosesN, Richards,FrankO, Cupp,EddieW, Unnasch,ThomasR, Michael,Edwin]
通讯作者:
Michael,Edwin
共 8 条
Ecdysteroid Signaling in Filarial Parasites
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批准号:8581279
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项目类别:
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资助金额:$21.76万
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财政年份:2013
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负责人:THOMAS R UNNASCH
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依托单位:
Delineating EEEV Over-Wintering and Early Season Amplification Mechanisms
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批准号:8698506
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项目类别:
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资助金额:$34.3万
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财政年份:2013
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负责人:THOMAS R UNNASCH
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依托单位:
Ecdysteroid Signaling in Filarial Parasites
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批准号:8720685
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项目类别:
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资助金额:$19.02万
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财政年份:2013
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负责人:THOMAS R UNNASCH
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依托单位:
Spatial modeling of onchocerciasis foci in Africa by remote sensing
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批准号:8587508
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项目类别:
-
资助金额:$38.41万
-
财政年份:2009
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负责人:THOMAS R UNNASCH
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依托单位:
Spatial modeling of onchocerciasis foci in Africa by remote sensing
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批准号:7836919
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项目类别:
-
资助金额:$40.0万
-
财政年份:2009
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负责人:THOMAS R UNNASCH
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依托单位:
Ecology of Encephalitis Viruses in the USA
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批准号:7846709
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项目类别:
-
资助金额:$6.87万
-
财政年份:2009
-
负责人:THOMAS R UNNASCH
-
依托单位:
Spatial modeling of onchocerciasis foci in Africa by remote sensing
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批准号:8369859
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项目类别:
-
资助金额:$37.62万
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财政年份:2009
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负责人:THOMAS R UNNASCH
-
依托单位:
Spatial modeling of onchocerciasis foci in Africa by remote sensing
-
批准号:8152754
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项目类别:
-
资助金额:$39.6万
-
财政年份:2009
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负责人:THOMAS R UNNASCH
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依托单位:
Mapping Protein Interactions between Filaria and its Wolbachia Endosymbiont
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批准号:7370744
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项目类别:
-
资助金额:$40.81万
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财政年份:2008
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负责人:THOMAS R UNNASCH
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依托单位:
Mapping Protein Interactions between Filaria and its Wolbachia Endosymbiont
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批准号:7617551
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项目类别:
-
资助金额:$39.62万
-
财政年份:2008
-
负责人:THOMAS R UNNASCH
-
依托单位:
Mapping Protein Interactions between Filaria and its Wolbachia Endosymbiont
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批准号:8049002
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项目类别:
-
资助金额:$40.0万
-
财政年份:2008
-
负责人:THOMAS R UNNASCH
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依托单位:
Mapping Protein Interactions between Filaria and its Wolbachia Endosymbiont
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批准号:7803612
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项目类别:
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资助金额:$40.4万
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财政年份:2008
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负责人:THOMAS R UNNASCH
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依托单位:
Ecology of West Nile Virus in the Southeastern US
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批准号:6953141
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项目类别:
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资助金额:$20.29万
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财政年份:2004
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负责人:THOMAS R UNNASCH
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依托单位:
Ecology of West Nile Virus in the Southeastern US
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批准号:6912854
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项目类别:
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资助金额:$20.88万
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财政年份:2004
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负责人:THOMAS R UNNASCH
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依托单位:
Ecology of West Nile Virus in the Southeastern US
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批准号:7119244
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项目类别:
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资助金额:$15.8万
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财政年份:2004
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负责人:THOMAS R UNNASCH
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依托单位:
Agents of International Health & Bioterrorism Concern
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批准号:6798130
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项目类别:
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资助金额:$27.77万
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财政年份:2003
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负责人:THOMAS R UNNASCH
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依托单位:
Agents of International Health & Bioterrorism Concern
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批准号:6941270
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项目类别:
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资助金额:$26.22万
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财政年份:2003
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负责人:THOMAS R UNNASCH
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依托单位:
Agents of International Health & Bioterrorism Concern
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批准号:7115819
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项目类别:
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资助金额:$27.9万
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财政年份:2003
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负责人:THOMAS R UNNASCH
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依托单位:
RETROVIRAL TRANSDUCTION AND IMMORTALIZATION OF FILARIA
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批准号:6691668
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项目类别:
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资助金额:$24.35万
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财政年份:2001
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负责人:THOMAS R UNNASCH
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依托单位:
Transfection and analysis of transcription in B. malayi
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批准号:6872502
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资助金额:$36.21万
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财政年份:2001
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负责人:THOMAS R UNNASCH
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依托单位:
海外基金