New Nanoparticle Strategies for Efficient Delivery and Controlled Release into the Brain

治疗神经退行性疾病的一个关键挑战是穿过血脑屏障（BBB）递送药物。本项目将在系统研究血脑屏障穿透机制和近红外药物控释策略的基础上，开发先进的血脑屏障“纳米梭”。这些递送系统可以促进脑部疾病的诊断和按需释放药物货物到脑部的病变细胞，为脑部疾病提供全新的局部治疗潜力。

A key challenge for treating neurodegenerative diseases is delivery of drugs across the blood–brain barrier (BBB). This project will develop advanced BBB “nanoshuttles” based upon systematic investigation of BBB penetration mechanisms and near-infrared drug controlled release strategy. These delivery systems may facilitate diagnosis of brain diseases and on-demand release of drug cargos to diseased cells in the brain, offering the potential of a brand new localised therapy for brain diseases.