Trajectories of Adverse Experiences Across the Life Course and Neighborhood Racial Segregation on Modifiable Cancer Risk Factors in African American Women
非裔美国女性一生中的不良经历轨迹和社区种族隔离对可改变癌症危险因素的影响
基本信息
- 批准号:10049179
- 负责人:
- 金额:$ 3.78万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-12-01 至 2021-11-30
- 项目状态:已结题
- 来源:
- 关键词:AdolescenceAdultAdverse eventAfrican AmericanAlcohol consumptionAlcoholsAttenuatedBiologicalBody SizeBody mass indexBody measure procedureCancer EtiologyCategoriesCessation of lifeChild AbuseChildhoodChronicColorectal CancerCompetenceCoping BehaviorData SetEducationElderlyElementsEnrollmentEnvironmentEnvironmental Risk FactorExposure toFunctional disorderHealthHealth behaviorHigh PrevalenceHouseholdIncidenceIncomeIndividualInjuryInterceptJointsLabelLifeLife Cycle StagesLinkLogistic RegressionsLongevityMalignant NeoplasmsMeasuresMethodologyModelingModificationMorbidity - disease rateNeighborhoodsObesityOutcomeOverweightPopulationPopulation Attributable RisksPrevalenceRaceResearchRisk BehaviorsRisk FactorsSamplingShapesSmokingSmoking StatusSocial EnvironmentSocioeconomic StatusStratificationStressTestingTobaccoTobacco useTrainingUnited StatesWaist-Hip RatioWomanWomen&aposs Healthabuse neglectblack womenbuilt environmentcancer epidemiologycancer health disparitycancer preventioncancer riskcigarette smokingcohortcritical perioddensitydesignenvironmental stressorexperiencefast foodfood deserthigh riskimprovedinnovationinsightmalignant breast neoplasmmalignant mouth neoplasmmortalitymultilevel analysispsychologicresidenceresidential segregationsegregationskillssocial epidemiologystressor
项目摘要
Project Summary
Cancer is a leading cause of morbidity and mortality among Black women with a substantial burden due to
alcohol use, smoking, and obesity. Despite growing evidence of the importance of early life adverse
experiences on long-term health, little is known about how chronic exposure to adverse experiences across the
life course influences cancer risk factors or risk behaviors among Black women. African American women are
particularly vulnerable to a higher burden of adverse experiences. Due to high levels of racial residential
segregation in the United States, African American women are also more likely than women of other races to
live in poor, segregated neighborhoods irrespective of individual education and income. Neighborhood context
may exacerbate effects of individual level adverse experiences. There is some evidence suggesting that
modifying the neighborhood may attenuate the effects of adverse experiences in early life. We hypothesize
that adverse experiences across the life course, compounded by living in a highly racially segregated
neighborhood in adulthood will result in a higher risk of unhealthy coping behaviors. Using the Black Women’s
Health Study, a cohort of 59,000 African American women (followed from 1995-present), we aim to 1) examine
the association between trajectories of adverse experiences in childhood, adolescence, and adulthood and
adult alcohol use, smoking, and body size in African American women and 2) determine if the association of
adverse experiences with adult alcohol use, smoking, and body size is modified by neighborhood racial
segregation and socioeconomic status.
This study will fill a critical gap in understanding the influence of early life adverse experiences on cancer risk
factors among Black women. Identifying critical periods and intervening earlier in the life course will yield
greater gains in reducing cancer disparities in this population. The proposed research incorporates several
innovative elements: 1) We are using a large, well powered dataset that was exclusive designed to elucidate
the drivers of a multitude of health outcomes among Black women;; 2) by incorporating a trajectory approach
we are able to assess how the timing and continuity of adverse experiences influence health behaviors;; 3) By
employing multilevel models we can examine the influence of multilevel (both individual and neighborhood)
stressors on health behaviors in this population;; 4) we are examining multiple measures of body size including
waist-to-hip ratio (WHR) and BMI. The interdisciplinary training environment for this proposal will provide the
applicant an opportunity to enhance methodological skills, build research competency, and enhance content
expertise, in order to become an expert in the intersection of cancer and social epidemiology.
项目摘要
癌症是黑人妇女发病率和死亡率的主要原因,
尽管越来越多的证据表明,早期生活的重要性,
长期健康的经验,很少有人知道如何长期暴露于不良经验,
生活过程影响黑人妇女的癌症危险因素或危险行为。
特别容易受到负面经历的更高负担的影响。由于高水平的种族居住
在美国的种族隔离中,非洲裔美国妇女也比其他种族的妇女更有可能
居住在贫穷、隔离的社区,而不考虑个人的教育和收入。
可能会加剧个人层面的不良经历的影响。有一些证据表明,
改变邻里关系可能会减弱早期生活中不良经历的影响。
生活在高度种族隔离的环境中,
成年后的邻居会导致更高的不健康应对行为的风险。
健康研究,一个由59,000名非洲裔美国妇女组成的队列(从1995年至今),我们的目标是1)检查
童年、青春期和成年期不良经历轨迹之间的关联,
非裔美国妇女的成年饮酒、吸烟和体型; 2)确定
成人饮酒、吸烟和体型的不良经历受邻近种族的影响
隔离和社会经济地位。
这项研究将填补理解早期生活不良经历对癌症风险影响的关键空白
黑人妇女的因素。确定关键时期和干预早期的生命历程将产生
在减少这一人群的癌症差异方面取得更大的进展。拟议的研究包括几个
创新元素:1)我们使用了一个大型的,动力良好的数据集,该数据集是专门设计来阐明
黑人女性多种健康结果的驱动因素; 2)通过纳入轨迹方法
我们能够评估不良经历的时间和连续性如何影响健康行为;
采用多水平模型,我们可以检查多水平(个人和邻居)的影响,
压力因素对健康行为的影响; 104)我们正在研究身体大小的多种测量方法,包括
腰臀比(WHR)和BMI。本建议的跨学科培训环境将提供
申请人有机会提高方法技能,建立研究能力,并提高内容
专业知识,以便成为癌症和社会流行病学交叉领域的专家。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Ekland Abdiwahab的其他文献
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{{ truncateString('Ekland Abdiwahab', 18)}}的其他基金
Trajectories of Adverse Experiences Across the Life Course and Neighborhood Racial Segregation on Modifiable Cancer Risk Factors in African American Women
非裔美国女性一生中的不良经历轨迹和社区种族隔离对可改变癌症危险因素的影响
- 批准号:
9911584 - 财政年份:2019
- 资助金额:
$ 3.78万 - 项目类别:
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