Dietary patterns and hearing loss in middle aged and older Americans

美国中老年人的饮食模式和听力损失

• 批准号: 10057706
• 负责人: Sameera A Talegawkar
• 金额: $ 8.92万
• 依托单位: GEORGE WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10057706
• 关键词: Address; Adherence; Adult; Affect; Age; Age of Onset; Aging; Alzheimer' s disease related dementia; American; Baltimore; Chronic; Chronic Disease; Country; DASH diet; Data; Databases; Dementia; Diet; Dietary Factors; Dietary Practices; Eating; Elderly; Ethnic Origin; Food; Frequencies; Guidelines; Health; Health Benefit; Hearing; Hearing Tests; Heart Diseases; Heart Rate; Hybrids; Incidence; Individual; Institutionalization; Intervention; Investigation; Knowledge; Labyrinth; Literature; Longitudinal Studies; Low Frequency Deafness; Measures; Mediating; Mediterranean Diet; Mediterranean Region; Methods; Nerve Degeneration; Noise; Nutrient; Nutrition Policy; Nutritional Study; Outcome; Outcome Study; Participant; Patient Self-Report; Pattern; Physical Function; Presbycusis; Prevalence; Prevention; Prospective Studies; Public Health; Race; Research; Research Design; Research Personnel; Role; Sum; United States; United States Department of Agriculture; Woman; age related; aged; base; cognitive function; design; disability; follow-up; frailty; hearing impairment; indexing; longitudinal design; men; middle age; prevent; prevent hearing loss; prospective; protective effect; secondary analysis; sex; statistics; trend

PROJECT SUMMARY Hearing loss is highly prevalent among older individuals, and affects approximately half of all adults over the age of 60 years in the United States (U.S.) Notably, given the current aging trends in the country, the number of older adults with hearing loss is projected to double by the year 2060. Previously considered as an inconsequential aspect of aging, recent research has implicated hearing loss as an independent predictor of age-related declines in physical and cognitive functioning, incident dementia, disability, and institutionalization. There is, therefore, an urgent need for the identification of effective strategies in delaying the onset and preventing aging-associated hearing loss. Dietary factors are considered to influence hearing status by mediating vulnerability of the inner ear to noise insult and to detrimental age-related changes. And while several nutrients and overall diet quality have been studied, a significant limitation of the literature to date has been either cross-sectional design or use of self-report for measuring hearing status, which has low sensitivity compared to objectively measured hearing loss or limited generalizability due to inclusion of only one sex, predominantly one race/ethnicity and short follow-up period. Dietary patterns now form the basis of nutrition research and policy; and there is accumulating evidence on the benefits of following a Mediterranean-style diet in the prevention of chronic diseases and age-related declines in physical and cognitive functioning. However, there are no investigations that have examined its associations in a carefully designed study with objectively measured hearing loss. We therefore propose to address this gap in research, by conducting a study to: (a) characterize adherence to a Mediterranean-style dietary pattern in middle aged and older adults living in the U.S. using three indices, one based the traditional Mediterranean diet, another based on the federal guidelines and the third based on a hybrid of Mediterranean and the Dietary Approaches to Stop Hypertension patterns, (b) examine whether adherence to a Mediterranean-style diet, assessed using these indices, is associated with and is a predictor of age-related hearing loss, and lastly, (c) determine the associations between a Mediterranean-style dietary pattern on high and low frequency hearing loss. This study will be conducted in the NIA-supported Baltimore Longitudinal Study of Aging (BLSA). The BLSA provides us the opportunity for prospective analyses and includes dietary data collected using valid methods, hearing loss which has been objectively assessed using audiometry examinations, and a wealth of data on potential covariates and confounders has also been collected.

项目摘要 听力损失在老年人中非常普遍，并且影响了大约一半的成年人。 60岁在美国（美国）值得注意的是，鉴于该国目前的老龄化趋势， 预计到2060年，听力损失的老年人人数将翻一番。以前被认为是 虽然听力损失是衰老的一个无关紧要的方面，但最近的研究表明听力损失是衰老的一个独立预测因素。 与年龄相关的身体和认知功能下降，痴呆症，残疾和机构化。 因此，迫切需要确定有效的战略， 预防与年龄相关的听力损失。饮食因素被认为通过以下方式影响听力状态： 介导内耳对噪声损伤和有害的年龄相关变化的脆弱性。虽然 已经研究了几种营养素和整体饮食质量，迄今为止文献的一个重要局限是， 采用横断面设计或自我报告的方法测量听力状况，灵敏度较低 与客观测量的听力损失或由于仅包括一种性别而导致的有限的普遍性相比， 主要是一个人种/种族，随访期短。饮食模式现在构成了营养的基础 研究和政策;并且有越来越多的证据表明遵循地中海式饮食的好处 在预防慢性疾病和与年龄有关的身体和认知功能下降方面。然而，在这方面， 没有研究在一项精心设计的研究中客观地检查其关联， 测得的听力损失因此，我们建议通过开展以下研究来解决研究中的这一差距： 描述生活在中东的中老年人坚持地中海式饮食模式的特征。 美国使用三个指数，一个基于传统的地中海饮食，另一个基于联邦指南 第三种基于地中海和饮食方法的混合，以阻止高血压模式， (b)检查是否坚持地中海式饮食，使用这些指数评估，与 是与年龄相关的听力损失的预测因素，最后，（c）确定 地中海式饮食模式对高低频听力损失的影响。本研究将在 美国国家情报局支持的巴尔的摩老龄化纵向研究（BLSA）。BLSA为我们提供了机会， 前瞻性分析，包括使用有效方法收集的饮食数据， 使用测听检查进行客观评估，以及大量潜在协变量数据， 还收集了混杂因素。