Real-Time L-Dopa Monitoring for Improved Management of Parkinson Disease

实时左旋多巴监测可改善帕金森病的管理

• 批准号: 10056836
• 负责人: Irene Litvan
• 金额: $ 43.39万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10056836
• 关键词: Accounting; Address; Award; Behavioral; Blood; Chemicals; Clinical; Data; Decentralization; Detection; Development; Devices; Diabetes Mellitus; Disease; Disease Management; Dopamine; Dose; Effectiveness; Electrochemistry; Ensure; Fatigue; Feedback; Goals; Gold; High Pressure Liquid Chromatography; Hour; Individual; Insulin Infusion Systems; Intercellular Fluid; Knowledge; Lead; Legal patent; Levodopa; Measures; Methods; Modernization; Monitor; Moods; Motor; Movement Disorders; Multi-site clinical study; Neurologist; Neurosciences; Oral; Outcome; Parkinson Disease; Patients; Performance; Pharmaceutical Preparations; Physicians; Plasma; Public Health; Publications; Pump; Regimen; Research; Resources; Specialist; Surface; Symptoms; System; Technology; Time; Treatment Efficacy; base; design; diabetes management; drug testing; experience; glucose monitor; high standard; illness length; improved; innovation; insight; meter; minimally invasive; multidisciplinary; multimodality; non-motor symptom; novel; precision medicine; real time monitoring; response; sensor; symptom management; wearable sensor technology

Project Summary The administration of L-Dopa therapies is highly individualized and must be dosed in accordance with the control of symptoms, which vary among individuals; hence, there is no “standard dose” of L-Dopa. The long-term goal of this project is to develop a wearable microneedle sensor for continuous real-time monitoring of L-Dopa toward identifying the proper L-Dopa dosing regimen and improving the management of Parkinson's disease. Such continuous L-Dopa monitoring capability would constitute a paradigm shift by allowing PD patients and physicians to better manage the disease. As with a closed- loop glucose monitor-insulin pump system, the insight gathered from this research could lead towards the development of a metered L-Dopa pump, ensuring accurate L-Dopa administration by accounting for circulating blood levels of L-Dopa. The proposed research is significant because of its potential to improve public health through improved understanding of symptom fluctuations at different disease stages and its contribution to scientific knowledge about how to improve the disease management.

项目摘要 左旋多巴治疗的给药是高度个体化的，必须根据临床试验的要求给药。 控制症状，这是因人而异的;因此，没有“标准剂量”的左旋多巴。的 该项目的长期目标是开发一种可穿戴的微针传感器，用于连续实时 监测左旋多巴，以确定适当的左旋多巴给药方案，并改善 帕金森病的治疗这种连续的L-多巴监测能力将构成一种 通过允许PD患者和医生更好地管理疾病来实现范式转变。就像一个封闭的- 环路葡萄糖监测器-胰岛素泵系统，从这项研究中收集的见解可能导致 开发了一种定量的左旋多巴泵，通过考虑 血液中左旋多巴的含量这项研究之所以重要，是因为它有可能 通过更好地了解不同疾病症状波动来改善公共卫生 阶段及其对如何改善疾病管理的科学知识的贡献。

项目成果

[18F]PI-2620 Binding Patterns in Patients with Suspected Alzheimer Disease and Frontotemporal Lobar Degeneration.

[18F]PI-2620 在疑似阿尔茨海默病和额颞叶变性患者中的结合模式。

• DOI: 10.2967/jnumed.123.265856
• 发表时间: 2023
• 期刊: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
• 作者: Blazhenets,Ganna;Soleimani-Meigooni,DavidN;Thomas,Wesley;Mundada,Nidhi;Brendel,Matthias;Vento,Stephanie;VandeVrede,Lawren;Heuer,HilaryW;Ljubenkov,Peter;Rojas,JulioC;Chen,MirandaK;Amuiri,AlindaN;Miller,Zachary;Gorno-Tempini,
• 通讯作者: Gorno-Tempini,

Recognition memory and divergent cognitive profiles in prodromal genetic frontotemporal dementia.

• DOI: 10.1016/j.cortex.2021.03.006
• 发表时间: 2021-06
• 期刊: Cortex; a journal devoted to the study of the nervous system and behavior
• 作者: Barker MS;Manoochehri M;Rizer SJ;Appleby BS;Brushaber D;Dev SI;Devick KL;Dickerson BC;Fields JA;Foroud TM;Forsberg LK;Galasko DR;Ghoshal N;Graff-Radford NR;Grossman M;Heuer HW;Hsiung GY;Kornak J;Litvan I;Mackenzie IR;Mendez MF;Pascual B;Rankin KP;Rascovsky K;Staffaroni AM;Tartaglia MC;Weintraub S;Wong B;Boeve BF;Boxer AL;Rosen HJ;Goldman J;Huey ED;Cosentino S;ALLFTD consortium
• 通讯作者: ALLFTD consortium

Sex differences for phenotype in pathologically defined dementia with Lewy bodies.

• DOI: 10.1136/jnnp-2020-325668
• 发表时间: 2021-07
• 期刊: Journal of neurology, neurosurgery, and psychiatry
• 作者: Bayram E;Coughlin DG;Banks SJ;Litvan I
• 通讯作者: Litvan I

Non-Invasive Sweat-Based Tracking of L-Dopa Pharmacokinetic Profiles Following an Oral Tablet Administration.

• DOI: 10.1002/anie.202106674
• 发表时间: 2021-08-23
• 期刊: Angewandte Chemie (International ed. in English)
• 作者: Moon JM;Teymourian H;De la Paz E;Sempionatto JR;Mahato K;Sonsa-Ard T;Huang N;Longardner K;Litvan I;Wang J
• 通讯作者: Wang J

Why Therapeutic Trials Fail in Primary Tauopathies.

为什么原发性 Tau蛋白病的治疗试验失败。

• DOI: 10.1002/mds.29322
• 发表时间: 2023
• 期刊: Movement disorders : official journal of the Movement Disorder Society
• 作者: Olfati,Nahid;Ghodsi,Hamidreza;Bayram,Ece;Litvan,Irene
• 通讯作者: Litvan,Irene