Validation of Transabdominal Fetal Pulse Oximetry in Hypoxic Fetal Lamb Models

经腹胎儿脉搏血氧饱和度在缺氧胎儿羔羊模型中的验证

基本信息

  • 批准号:
    10057202
  • 负责人:
  • 金额:
    $ 22.68万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-07-15 至 2022-06-30
  • 项目状态:
    已结题

项目摘要

Project Summary Despite significant cost and clear evidence of health risks associated with Cesarean deliveries (C-sections), an unnecessarily large number of infants are delivered via C-sections in the US. The high rate of C-sections in the nation, relative to globally accepted norms, is in part attributed to the high false positive rate of fetal distress, associated with the current half-a-century-old intrapartum fetal monitoring technology. The long-term vision of this project is to alleviate this problem, by developing an improved and more specific technology for intrapartum fetal health monitoring. Specifically, we have developed the technology and built a device prototype for non-invasive, transabdominal measurement of fetal arterial blood oxygen saturation (FSpO2). The device works by shining light in the abdominal area at two specific near infrared wavelengths, followed by sensing the weak back scattered light reflections transcutaneously. The sensed signals are subsequently processed to remove various noises, including the unwanted maternal contributions, from the measurements to infer variations in light intensity that are strictly due to pulsation of fetal arteries. The device prototype is successfully validated in several preliminary tests, including simulations, photo-plethysmography (PPG) acquisition in human subjects through a thick optical phantom mimicking optical properties of a pregnant woman's abdominal area, PPG detection and separation of emulated fetal signal through an emulated maternal tissue, and in-vivo validation in a hypoxic fetal lamb model. To further advance the technology, we aim to investigate device's accuracy and reliability in measuring FSpO2 in hypoxic fetal lamb models (n=18). Our animal study protocol, already demonstrated to be effective in our preliminary work, includes hysterotomy to cannulate lamb fetus for fetal hemodynamic monitoring and drawing fetal blood samples, and placement of an inflatable catheter in the maternal aorta through which, we regulate the ewe's blood supply to the uterus, and induce controllable fetal hypoxia. The study will enable us to collect gold standard fetal arterial blood oxygen saturation (FSaO2) data via arterial blood gas (ABG) tests, under a number of hypoxia scenarios, and to compare them against our device's concurrent measurements. The study is organized into two complementary groups, depending on whether the uterus is closed around the fetal neck (n=9) or the fetus is fully returned to the uterus (n=9) before closing ewe's abdominal fascia, which enables us to isolate the impact of different tissue layers, and to characterize the technology's operating range and limitations. The project will provide the foundation for unleashing the potential clinical impact of the technology down the road.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Diana Lee Farmer其他文献

Antibiotics alone versus appendicectomy for uncomplicated appendicitis in children
单纯使用抗生素与阑尾切除术治疗儿童单纯性阑尾炎的比较
  • DOI:
    10.1016/s0140-6736(25)00096-0
  • 发表时间:
    2025-01-18
  • 期刊:
  • 影响因子:
    88.500
  • 作者:
    Diana Lee Farmer
  • 通讯作者:
    Diana Lee Farmer
Continuous Transabdominal Fetal Pulse Oximetry (TFO) in Pregnant Ewe Models under Induced Fetal Hypoxia
诱导胎儿缺氧下怀孕母羊模型的连续经腹胎儿脉搏血氧饱和度 (TFO)
  • DOI:
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    9.8
  • 作者:
    Weitai Qian;Kourosh Vali;Begum Kasap;C. Pivetti;Christina M. Theodorou;E. Kulubya;Kaeli J. Yamashiro;Aijun Wang;H. Hedriana;Diana Lee Farmer;S. Ghiasi
  • 通讯作者:
    S. Ghiasi
Thrombocytopenia in Pediatric Oncology Patients: A Good Reason to Delay Central Venous Catheter Insertion?
  • DOI:
    10.1016/j.jamcollsurg.2020.07.777
  • 发表时间:
    2020-10-01
  • 期刊:
  • 影响因子:
  • 作者:
    Sarah C. Stokes;Kaeli J. Yamashiro;Jordan E. Jackson;Christina M. Theodorou;Diana Lee Farmer;Shinjiro Hirose;Payam Saadai;Alana L. Beres;Erin M.D. Brown
  • 通讯作者:
    Erin M.D. Brown

Diana Lee Farmer的其他文献

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{{ truncateString('Diana Lee Farmer', 18)}}的其他基金

Engineered Neuroprotective Stem-Cell Exosomes for In Utero Spina Bifida Therapy
用于子宫内脊柱裂治疗的工程神经保护干细胞外泌体
  • 批准号:
    10705047
  • 财政年份:
    2020
  • 资助金额:
    $ 22.68万
  • 项目类别:
Engineered neuroprotective stem-cell exosomes for in utero spina bifida therapy
用于子宫内脊柱裂治疗的工程神经保护干细胞外泌体
  • 批准号:
    10271311
  • 财政年份:
    2020
  • 资助金额:
    $ 22.68万
  • 项目类别:
Validation of Transabdominal Fetal Pulse Oximetry in Hypoxic Fetal Lamb Models
经腹胎儿脉搏血氧饱和度在缺氧胎儿羔羊模型中的验证
  • 批准号:
    10214652
  • 财政年份:
    2020
  • 资助金额:
    $ 22.68万
  • 项目类别:
MULTICENTER TRIAL OF FETAL MYELOMENINGOCELE REPAIR
胎儿脊髓脊膜膨出修复的多中心试验
  • 批准号:
    7940506
  • 财政年份:
    2002
  • 资助金额:
    $ 22.68万
  • 项目类别:
MULTICENTER TRIAL OF FETAL MYELOMENINGOCELE REPAIR
胎儿脊髓脊膜膨出修复的多中心试验
  • 批准号:
    7567854
  • 财政年份:
    2002
  • 资助金额:
    $ 22.68万
  • 项目类别:

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