Validation of Transabdominal Fetal Pulse Oximetry in Hypoxic Fetal Lamb Models

经腹胎儿脉搏血氧饱和度在缺氧胎儿羔羊模型中的验证

基本信息

  • 批准号:
    10057202
  • 负责人:
  • 金额:
    $ 22.68万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-07-15 至 2022-06-30
  • 项目状态:
    已结题

项目摘要

Project Summary Despite significant cost and clear evidence of health risks associated with Cesarean deliveries (C-sections), an unnecessarily large number of infants are delivered via C-sections in the US. The high rate of C-sections in the nation, relative to globally accepted norms, is in part attributed to the high false positive rate of fetal distress, associated with the current half-a-century-old intrapartum fetal monitoring technology. The long-term vision of this project is to alleviate this problem, by developing an improved and more specific technology for intrapartum fetal health monitoring. Specifically, we have developed the technology and built a device prototype for non-invasive, transabdominal measurement of fetal arterial blood oxygen saturation (FSpO2). The device works by shining light in the abdominal area at two specific near infrared wavelengths, followed by sensing the weak back scattered light reflections transcutaneously. The sensed signals are subsequently processed to remove various noises, including the unwanted maternal contributions, from the measurements to infer variations in light intensity that are strictly due to pulsation of fetal arteries. The device prototype is successfully validated in several preliminary tests, including simulations, photo-plethysmography (PPG) acquisition in human subjects through a thick optical phantom mimicking optical properties of a pregnant woman's abdominal area, PPG detection and separation of emulated fetal signal through an emulated maternal tissue, and in-vivo validation in a hypoxic fetal lamb model. To further advance the technology, we aim to investigate device's accuracy and reliability in measuring FSpO2 in hypoxic fetal lamb models (n=18). Our animal study protocol, already demonstrated to be effective in our preliminary work, includes hysterotomy to cannulate lamb fetus for fetal hemodynamic monitoring and drawing fetal blood samples, and placement of an inflatable catheter in the maternal aorta through which, we regulate the ewe's blood supply to the uterus, and induce controllable fetal hypoxia. The study will enable us to collect gold standard fetal arterial blood oxygen saturation (FSaO2) data via arterial blood gas (ABG) tests, under a number of hypoxia scenarios, and to compare them against our device's concurrent measurements. The study is organized into two complementary groups, depending on whether the uterus is closed around the fetal neck (n=9) or the fetus is fully returned to the uterus (n=9) before closing ewe's abdominal fascia, which enables us to isolate the impact of different tissue layers, and to characterize the technology's operating range and limitations. The project will provide the foundation for unleashing the potential clinical impact of the technology down the road.
项目摘要 尽管剖腹产的成本很高,而且有明显的证据表明剖腹产会带来健康风险, 在美国,不必要地大量婴儿通过剖腹产分娩。剖腹产的高比率 相对于全球公认的规范,这个国家的部分原因是胎儿窘迫的假阳性率很高, 与目前已有半个世纪历史的产时胎儿监测技术有关。长期构想 该项目的目的是通过开发一种改进的、更具体的技术来缓解这一问题, 产时胎儿健康监测。 具体来说,我们已经开发了这项技术,并建立了一个设备原型,用于非侵入性,经腹 测量胎儿动脉血氧饱和度(FSpO2)。该装置的工作原理是在 腹部区域在两个特定的近红外波长,其次是感测弱回散射光 透射反射随后处理感测到的信号以去除各种噪声, 包括不想要的母亲贡献,从测量结果中推断光强度的变化 这是由胎儿动脉搏动引起的该设备原型成功地验证了几个 初步测试,包括模拟,人体受试者的光电体积描记(PPG)采集, 厚光学体模模仿孕妇腹部区域的光学特性,PPG检测 以及通过仿真母体组织分离仿真胎儿信号,以及在 缺氧胎羊模型。 为了进一步发展这项技术,我们的目标是研究设备在测量FSpO2方面的准确性和可靠性 在缺氧胎羊模型中(n=18)。我们的动物研究方案,已经证明是有效的, 初步工作包括子宫切开术,为羊胎儿插管,以监测胎儿血流动力学, 抽取胎儿血液样本,并在母体主动脉中放置可充气导管, 调节母羊子宫的血液供应,并诱导可控的胎儿缺氧。这项研究将使我们能够 通过动脉血气(ABG)测试收集金标准胎儿动脉血氧饱和度(FSaO2)数据, 在一些缺氧的情况下,并将它们与我们的设备的并发测量进行比较。 这项研究分为两个互补的小组,这取决于子宫周围是否关闭。 胎儿颈部(n=9)或胎儿完全返回子宫(n=9),然后关闭母羊的腹部筋膜, 使我们能够隔离不同组织层的影响,并描述该技术的操作范围 和局限性。该项目将为释放其潜在的临床影响提供基础 技术在路上。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Diana Lee Farmer其他文献

Antibiotics alone versus appendicectomy for uncomplicated appendicitis in children
单纯使用抗生素与阑尾切除术治疗儿童单纯性阑尾炎的比较
  • DOI:
    10.1016/s0140-6736(25)00096-0
  • 发表时间:
    2025-01-18
  • 期刊:
  • 影响因子:
    88.500
  • 作者:
    Diana Lee Farmer
  • 通讯作者:
    Diana Lee Farmer
Continuous Transabdominal Fetal Pulse Oximetry (TFO) in Pregnant Ewe Models under Induced Fetal Hypoxia
诱导胎儿缺氧下怀孕母羊模型的连续经腹胎儿脉搏血氧饱和度 (TFO)
  • DOI:
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    9.8
  • 作者:
    Weitai Qian;Kourosh Vali;Begum Kasap;C. Pivetti;Christina M. Theodorou;E. Kulubya;Kaeli J. Yamashiro;Aijun Wang;H. Hedriana;Diana Lee Farmer;S. Ghiasi
  • 通讯作者:
    S. Ghiasi
Thrombocytopenia in Pediatric Oncology Patients: A Good Reason to Delay Central Venous Catheter Insertion?
  • DOI:
    10.1016/j.jamcollsurg.2020.07.777
  • 发表时间:
    2020-10-01
  • 期刊:
  • 影响因子:
  • 作者:
    Sarah C. Stokes;Kaeli J. Yamashiro;Jordan E. Jackson;Christina M. Theodorou;Diana Lee Farmer;Shinjiro Hirose;Payam Saadai;Alana L. Beres;Erin M.D. Brown
  • 通讯作者:
    Erin M.D. Brown

Diana Lee Farmer的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Diana Lee Farmer', 18)}}的其他基金

Engineered Neuroprotective Stem-Cell Exosomes for In Utero Spina Bifida Therapy
用于子宫内脊柱裂治疗的工程神经保护干细胞外泌体
  • 批准号:
    10705047
  • 财政年份:
    2020
  • 资助金额:
    $ 22.68万
  • 项目类别:
Engineered neuroprotective stem-cell exosomes for in utero spina bifida therapy
用于子宫内脊柱裂治疗的工程神经保护干细胞外泌体
  • 批准号:
    10271311
  • 财政年份:
    2020
  • 资助金额:
    $ 22.68万
  • 项目类别:
Validation of Transabdominal Fetal Pulse Oximetry in Hypoxic Fetal Lamb Models
经腹胎儿脉搏血氧饱和度在缺氧胎儿羔羊模型中的验证
  • 批准号:
    10214652
  • 财政年份:
    2020
  • 资助金额:
    $ 22.68万
  • 项目类别:
MULTICENTER TRIAL OF FETAL MYELOMENINGOCELE REPAIR
胎儿脊髓脊膜膨出修复的多中心试验
  • 批准号:
    7940506
  • 财政年份:
    2002
  • 资助金额:
    $ 22.68万
  • 项目类别:
MULTICENTER TRIAL OF FETAL MYELOMENINGOCELE REPAIR
胎儿脊髓脊膜膨出修复的多中心试验
  • 批准号:
    7567854
  • 财政年份:
    2002
  • 资助金额:
    $ 22.68万
  • 项目类别:

相似海外基金

Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
  • 批准号:
    MR/S03398X/2
  • 财政年份:
    2024
  • 资助金额:
    $ 22.68万
  • 项目类别:
    Fellowship
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
  • 批准号:
    2338423
  • 财政年份:
    2024
  • 资助金额:
    $ 22.68万
  • 项目类别:
    Continuing Grant
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
  • 批准号:
    EP/Y001486/1
  • 财政年份:
    2024
  • 资助金额:
    $ 22.68万
  • 项目类别:
    Research Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
  • 批准号:
    MR/X03657X/1
  • 财政年份:
    2024
  • 资助金额:
    $ 22.68万
  • 项目类别:
    Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
  • 批准号:
    2348066
  • 财政年份:
    2024
  • 资助金额:
    $ 22.68万
  • 项目类别:
    Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
  • 批准号:
    AH/Z505481/1
  • 财政年份:
    2024
  • 资助金额:
    $ 22.68万
  • 项目类别:
    Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10107647
  • 财政年份:
    2024
  • 资助金额:
    $ 22.68万
  • 项目类别:
    EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
  • 批准号:
    2341402
  • 财政年份:
    2024
  • 资助金额:
    $ 22.68万
  • 项目类别:
    Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10106221
  • 财政年份:
    2024
  • 资助金额:
    $ 22.68万
  • 项目类别:
    EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
  • 批准号:
    AH/Z505341/1
  • 财政年份:
    2024
  • 资助金额:
    $ 22.68万
  • 项目类别:
    Research Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了