Development of Functional Magnetic Resonance Elastography for Mapping of Human Brain Function

项目摘要 脑成像的进展，包括功能磁共振成像(FMRI)的发展 增加了我们对大脑如何组织以支持神经功能以及哪些变化的理解 大脑功能障碍与许多神经和心理疾病有关。尤其与 在临床应用方面，功能磁共振成像带有一个临床计费代码，反映了它在脑外科手术前计划中的效用。 由于其对血流变化的依赖性，BOLD fmri同时遭受假阴性和假阳性的困扰。 结果。为了克服BOLD功能磁共振成像的一些局限性，我们建议研究应用 一种全新的磁共振成像技术--功能磁共振弹性成像(FMRE)，用于绘制人类地图 大脑功能。FMRE技术不依赖于神经血管反应，而是测量局部 由于神经功能的改变而导致的组织的机械变化。我们的数据表明，FMRE可以 在短时间内表现出神经反应，这不可能是由于大胆的反应。我们假设 FMRE与初级神经元活动紧密相连，因此不会受到相关问题的影响 带有大胆的功能磁共振成像。在这个项目中，我们建议研究fmre映射感觉运动功能的能力。 术前脑电地形图。我们建议使用以下方法比较和对比fMRE和BOLD fMRI激活 个体受试者的感觉运动任务。在目标1中，我们将确定两者之间的异同 健康受试者对感觉运动刺激的fMRE和fMRI反应，并探讨 测量独立于神经血管反应的神经机械反应 刺激开关速度。在目标2中，我们将研究脑肿瘤患者的fmre，以检验以下假设 FMRE不会受到BOLD fMRI中看到的问题的影响，并对照临床验证激活的区域 金标准的术中脑地形图。这是一项创新、高风险、高回报的探索 研究将确定FMRE用于感觉运动标测的可行性、可靠性和有效性。我们相信FMRE 将发展成为一种新的具有高时间分辨率和大范围的变革性脑地形图技术 神经科学和临床应用。

Project Summary Advances in brain mapping including the development of functional magnetic resonance imaging (fMRI) have increased our understanding of how the brain is organized to support neurologic functioning and what alterations in brain function are associated with numerous neurological and psychological illnesses. Particularly relevant for clinical applications, fMRI carries a clinical billing code reflecting its utility in presurgical planning for brain surgery. Due to its dependence on blood flow changes, BOLD fMRI suffers from both false negative and false positive results. To overcome some of the limitations of BOLD fMRI, we propose to investigate the feasibility of applying a completely novel MRI technique, functional magnetic resonance elastography (fMRE), for mapping human brain function. The fMRE technique does not depend on a neurovascular response, instead, it measures local mechanical changes in tissue resulting from a change in neuronal function. Our data has shown that fMRE can reveal neural responses at short timescales that cannot be due to the BOLD response. We hypothesize that fMRE is tightly coupled to primary neuronal activity, and hence will not be affected by the problems associated with BOLD fMRI. In this project, we propose to investigate the ability of fMRE to map sensorimotor function for presurgical brain mapping. We propose to compare and contrast fMRE and BOLD fMRI activations using sensorimotor tasks in individual subjects. In Aim 1, we will determine the similarities and differences between the fMRE and fMRI response to sensorimotor stimuli in healthy subjects, and investigate the feasibility of measuring neuromechanical responses which are independent from neurovascular response by varying the stimulus switching speed. In Aim 2, we will investigate fMRE in brain tumor patients to test the hypothesis that fMRE will not be affected by the problems seen in BOLD fMRI, and validate the activated regions against clinical gold-standard intra-operative brain mapping. This proposed innovative, high-risk, high-reward exploratory research will establish feasibility, reliability, and validity of fMRE for sensorimotor mapping. We believe that fMRE will develop into a novel transformative brain mapping technique with high temporal resolution and a broad range of neuroscience and clinical applications.