Development of Functional Magnetic Resonance Elastography for Mapping of Human Brain Function

项目摘要 包括功能性磁共振成像（fMRI）在内的脑成像技术的进展， 增加了我们对大脑如何组织以支持神经功能以及如何改变的理解 大脑功能的变化与许多神经和心理疾病有关。特别关系到 在临床应用中，功能磁共振成像携带临床计费代码，反映其在脑外科手术的术前规划中的实用性。 由于BOLD功能磁共振成像依赖于血流变化，因此存在假阴性和假阳性 结果为了克服BOLD功能磁共振成像的一些局限性，我们建议研究应用的可行性。 一种全新的MRI技术，功能性磁共振弹性成像（fMRE），用于映射人类 大脑功能fMRE技术不依赖于神经血管反应，而是测量局部 由于神经元功能的变化而导致的组织中的机械变化。我们的数据表明，fMRE可以 揭示了短时间尺度下的神经反应，这些反应不可能是由于BOLD反应造成的。我们假设 fMRE与初级神经元活动紧密耦合，因此不会受到相关问题的影响 功能性磁共振成像在这个项目中，我们建议调查fMRE映射感觉运动功能的能力， 手术前脑成像我们建议比较和对比fMRE和BOLD fMRI激活， 感觉运动任务。在目标1中，我们将确定 健康受试者对感觉运动刺激的fMRE和fMRI反应，并探讨 测量神经机械反应，其独立于神经血管反应，通过改变 刺激切换速度。在目标2中，我们将研究脑肿瘤患者的fMRE，以检验以下假设： fMRE将不会受到BOLD fMRI中出现的问题的影响，并验证激活的区域是否符合临床 黄金标准的术中脑标测这就提出了创新性、高风险、高回报的探索性 研究将建立用于感觉运动映射的fMRE的可行性、可靠性和有效性。我们认为， 将发展成为一种新的变革性的大脑映射技术，具有高时间分辨率和广泛的范围 神经科学和临床应用。

Project Summary Advances in brain mapping including the development of functional magnetic resonance imaging (fMRI) have increased our understanding of how the brain is organized to support neurologic functioning and what alterations in brain function are associated with numerous neurological and psychological illnesses. Particularly relevant for clinical applications, fMRI carries a clinical billing code reflecting its utility in presurgical planning for brain surgery. Due to its dependence on blood flow changes, BOLD fMRI suffers from both false negative and false positive results. To overcome some of the limitations of BOLD fMRI, we propose to investigate the feasibility of applying a completely novel MRI technique, functional magnetic resonance elastography (fMRE), for mapping human brain function. The fMRE technique does not depend on a neurovascular response, instead, it measures local mechanical changes in tissue resulting from a change in neuronal function. Our data has shown that fMRE can reveal neural responses at short timescales that cannot be due to the BOLD response. We hypothesize that fMRE is tightly coupled to primary neuronal activity, and hence will not be affected by the problems associated with BOLD fMRI. In this project, we propose to investigate the ability of fMRE to map sensorimotor function for presurgical brain mapping. We propose to compare and contrast fMRE and BOLD fMRI activations using sensorimotor tasks in individual subjects. In Aim 1, we will determine the similarities and differences between the fMRE and fMRI response to sensorimotor stimuli in healthy subjects, and investigate the feasibility of measuring neuromechanical responses which are independent from neurovascular response by varying the stimulus switching speed. In Aim 2, we will investigate fMRE in brain tumor patients to test the hypothesis that fMRE will not be affected by the problems seen in BOLD fMRI, and validate the activated regions against clinical gold-standard intra-operative brain mapping. This proposed innovative, high-risk, high-reward exploratory research will establish feasibility, reliability, and validity of fMRE for sensorimotor mapping. We believe that fMRE will develop into a novel transformative brain mapping technique with high temporal resolution and a broad range of neuroscience and clinical applications.