Development of Allosteric Dihydrofolate Reductase Inhibitors: Exploration of a Novel Inhibitory Mechanism for a Validated Antibiotic Target

变构二氢叶酸还原酶抑制剂的开发：探索经过验证的抗生素靶点的新型抑制机制

• 批准号: 10113254
• 负责人: Matthew C O'Reilly
• 金额: $ 34.09万
• 依托单位: VILLANOVA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-03-02 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10113254
• 关键词: Development; Allosteric; Dihydrofolate; Reductase; Inhibitors

项目成果

Synthesis and Characterization of Functionalized Amino Dihydropyrimidines Toward the Analysis of their Antibacterial Structure-Activity Relationships and Mechanism of Action.

• DOI: 10.1021/acsomega.2c05071
• 发表时间: 2022-10-25
• 期刊: ACS OMEGA
• 影响因子: 4.1
• 作者: Boyer, Zachary W.;Kessler, Hannah;Brosman, Hannah;Ruud, Kirsten J.;Falkowski, Alan F.;Viollet, Constance;Bourne, Christina R.;O'Reilly, Matthew C.
• 通讯作者: O'Reilly, Matthew C.