Intention Treatment for Anomia: Investigating Dose Frequency Effects and Predictors of Treatment Response to Improve Efficacy and Clinical Translation

失智症的意向治疗：研究剂量频率效应和治疗反应的预测因素，以提高疗效和临床转化

• 批准号: 10112761
• 负责人: Amy D Rodriguez
• 金额: --
• 依托单位: VETERANS HEALTH ADMINISTRATION
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-01 至 2024-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10112761
• 关键词: Address; Adjuvant; Age; Anomia; Aphasia; Behavior; Behavior assessment; Brain; Brain region; Chronic; Chronic Disease; Clinical; Cognitive; Computers; Data; Development; Dose; Family; Frequencies; Gestures; Goals; Hand; Health Care Costs; Healthcare Systems; Image; Impairment; Individual; Intention; Intervention; Knowledge; Language; Lead; Learning; Left; Lesion; Location; Maintenance; Memory; Neurologic; Neurophysiology - biologic function; Outcome; Participant; Patients; Prediction of Response to Therapy; Quality of life; Research; Resources; Retrieval; Schedule; Service delivery model; Societies; Stroke; Structure; Time; Training; Treatment Factor; Treatment outcome; Veterans; Word Processing; Work; aphasia rehabilitation; base; clinical decision-making; clinical practice; clinical translation; clinically translatable; cognitive function; cost; experience; follow-up; health related quality of life; image processing; improved; language impairment; military veteran; neuroimaging; novel; optimal treatments; predicting response; relating to nervous system; stroke-induced aphasia; telehealth; therapy design; treatment group; treatment response; trial comparing

Difficulty retrieving words is one of the most common language complaints in individuals with stroke- induced aphasia. The negative consequences related to word retrieval impairment include increased health care costs and decreased quality of life. A variety of treatment approaches exist to improve word retrieval, and most of the treatments result in immediate improvement on trained words. However, long-term improvement and improvement on untrained words or behaviors is less common. Additionally, we currently know very little about optimal treatment administration parameters and we know even less about predictors of treatment response. Our current healthcare system is not resourced to provide ongoing treatment for individuals with chronic aphasia. To make the best use of the clinical resources available for aphasia treatment, and to maximize outcomes for Veterans with aphasia, we must: 1) develop clinically translatable treatments that yield widespread and lasting effects and 2) develop clinically accessible ways of identifying who will acquire benefit from a specific treatment approach. The proposed study in this Merit Review Application takes on these two challenges by investigating dose frequency (massed vs. distributed practice) effects and identifying the language, cognitive and neural predictors of response to Intention treatment (INT), a novel word retrieval treatment. Our preliminary studies provide strong support for the proposed study, which we expect will increase the efficacy, clinical translatability, and potential for use of INT as an adjuvant to other word retrieval treatments. From a broader perspective, our results will help guide selection of the right treatment for the right Veteran. This work has direct implications for clinical practice in aphasia rehabilitation and has the potential to make a significant positive impact on the VA Healthcare System and on Veterans living with aphasia.

难以检索单词是中风的个体中最常见的语言抱怨之一 - 引起失语症。与单词检索障碍有关的负面后果包括健康 护理成本和生活质量下降。存在各种治疗方法来改善单词检索，并且 大多数治疗方法都会立即改善训练有素的单词。但是，长期改善 对未经训练的单词或行为的改善不太常见。此外，我们目前知道很少 关于最佳治疗管理参数，我们对治疗预测指标的了解更少 回复。我们当前的医疗保健系统没有资源为 慢性失语症。为了充分利用临床资源可用于失语症治疗，并 最大化失语症的退伍军人的结果，我们必须：1）开发可翻译的临床治疗方法 广泛而持久的效果以及2）开发临床上可访问的方法来识别谁将获得福利 来自特定的治疗方法。在此功绩审查申请中，拟议的研究对这两个 通过调查剂量频率（质量与分布式实践）效应并确定挑战 语言，认知和神经预测对意图治疗的反应（INT），一种新颖的单词检索 治疗。我们的初步研究为拟议的研究提供了大力支持，我们希望这将 提高使用INT作为其他单词检索的辅助物的功效，临床转换性和潜力 治疗。从更广泛的角度来看，我们的结果将有助于指导正确的正确处理 老将。这项工作对失语症康复具有直接影响，并有可能 对VA医疗保健系统和失语症的退伍军人产生重大积极影响。