卓越研究专业计划-猫眼课题宝

卓越研究专业计划

批准号：

8707192

负责人：

Robert L. Ferris

金额：

$215.55万

依托单位：

UNIVERSITY OF PITTSBURGH AT PITTSBURGH

依托单位国家：

美国

项目类别：

财政年份：

2004

资助国家：

美国

项目状态：

已结题

起止时间：

2004-07-01 至 2015-06-30

来源：

https://reporter.nih.gov/project-details/8707192

关键词：

Address Antibodies Antibody Therapy Apoptotic Applications Grants Applied Research Area Basic Science Behavior Therapy Biometry Blood Blood Tests Bortezomib Cancer Biology Cancer Center Cancer Vaccines Candidate Disease Gene Case-Control Studies Cell Cycle Cell Line Cells Cellular Immunity Cetuximab Chemoprevention Clinical Clinical Management Clinical Research Clinical Sciences Commit Communities Critiques Cytotoxic T-Lymphocytes DNA DNA Repair Gene Dasatinib Dendritic Cells Detection Development Diagnosis Disease EGFR inhibition Epidemiologic Studies Epidermal Growth Factor Receptor Faculty Feedback Funding Future G Protein-Coupled Receptor Genes Genetic Polymorphism Genetic Predisposition to Disease Goals Grant Growth Factor Receptors Head and Neck Cancer Head and Neck Neoplasms Head and Neck Squamous Cell Carcinoma Head and neck structure High-Risk Cancer Histology Human Immune Immune response Immunosuppression Immunotherapeutic agent Immunotherapy In Vitro Incidence Individual Informatics Institution Intervention Knowledge Laboratories Lead Lymphocyte Mediating Medical Medicine Mentors Mentorship Methods Mission Modeling Molecular Molecular Target Monitor Monoclonal Antibodies Morbidity - disease rate Mutation National Institute of Dental and Craniofacial Research Natural Killer Cells Neoadjuvant Therapy Oral Organ Otolaryngology Outcome Participant Pathway interactions Patients Peer Review Peptides Phase Phase I Clinical Trials Phase II Clinical Trials Population Positioning Attribute Postdoctoral Fellow Pre-Clinical Model Predisposition Primary Neoplasm Principal Investigator Proteasome Inhibition Reagent Receptor Signaling Recruitment Activity Regimen Regulator Genes Research Research Activity Research Methodology Research Personnel Research Project Grants Research Training Resistance Resources Risk Risk Assessment Role STAT3 gene Schools Signal Pathway Signal Transduction Signal Transduction Pathway Smoke Solid Neoplasm Source Specialized Program of Research Excellence Subgroup Target Populations Testing Therapeutic Tissue Banking Tissue Banks Training Training Programs Translational Research Treatment outcome United States National Institutes of Health Universities University of Pittsburgh Cancer Institute Vaccines Work alcohol exposure anticancer research base cancer risk career career development clinical practice clinically relevant clinically significant design drinking flexibility genetic risk factor genome wide association study high risk improved in vivo inhibitor/antagonist innovation interdisciplinary approach interest kinase inhibitor malignant mouth neoplasm meetings member minimally invasive mortality neoplastic cell novel novel strategies oncology outcome forecast pre-clinical programs research study response screening src-Family Kinases tobacco exposure treatment response tumor

项目摘要

项目成果

Robert L. Ferris的其他基金

相似基金

相关文献

中文摘要

翻译

点击翻译按钮获取中文摘要

英文摘要

The University of Pittsburgh proposes to continue a Specialized Program of Research Excellence (SPORE) in Head and Neck Cancer. The overall goals of the Pittsburgh Head and Neck SPORE are to improve the detection, and treatment of head and neck cancer. The SPORE program consists of four translational research projects in head and neck cancer, two research cores, an administrative core, a developmental research program and a career development program. The University of Pittsburgh Head and Neck SPORE will use an interdisciplinary approach to meet its objectives by carrying out projects with co-investigators in basic, applied and clinical science. It is also organ-specific in that its approach and all projects will test hypotheses about head and neck cancer biology, susceptibility, detection, or treatment. The long-term goal of the Head and Neck SPORE is to conduct clinical studies based on research results from the translational research projects that will serve as the basis for improving the outcome of patients diagnosed with head and neck cancer. The four main projects include: (1) Pathway and GWAS-SNPs: Role in SCCHN Risk, Outcome and Treatment; (2) Inhibition of the STATS Signaling Network; (3) Cellular Immunity and Immune Escape for EGFR Antibody Therapy; and (4) Therapeutic Mechanisms of Co-Targeting EGFR and Src Family Kinases. The three cores will interact closely to assist the main research projects, developmental research projects and the career development investigators in carrying out translational head and neck cancer research. The research cores include: (1) Histology/Tissue Banking and (2) Biostatistics and Informatics. The Administrative Core will solicit feedback from the Internal and External Scientific Advisory Boards and provide scientific, regulatory and fiscal oversight for the SPORE program. The Head and Neck SPORE investigators will work together to synergistically achieve the goals of the program and will also interact with investigators from SPOREs at other institutions to improve the outcome of patients with cancer of the head and neck.

期刊论文(0)

专著(0)

科研奖励(0)

会议论文