卓越研究专业计划-猫眼课题宝

卓越研究专业计划

批准号：

8707192

负责人：

Robert L. Ferris

金额：

$215.55万

依托单位：

UNIVERSITY OF PITTSBURGH AT PITTSBURGH

依托单位国家：

美国

项目类别：

财政年份：

2004

资助国家：

美国

项目状态：

已结题

起止时间：

2004-07-01 至 2015-06-30

来源：

https://reporter.nih.gov/project-details/8707192

关键词：

Address Antibodies Antibody Therapy Apoptotic Applications Grants Applied Research Area Basic Science Behavior Therapy Biometry Blood Blood Tests Bortezomib Cancer Biology Cancer Center Cancer Vaccines Candidate Disease Gene Case-Control Studies Cell Cycle Cell Line Cells Cellular Immunity Cetuximab Chemoprevention Clinical Clinical Management Clinical Research Clinical Sciences Commit Communities Critiques Cytotoxic T-Lymphocytes DNA DNA Repair Gene Dasatinib Dendritic Cells Detection Development Diagnosis Disease EGFR inhibition Epidemiologic Studies Epidermal Growth Factor Receptor Faculty Feedback Funding Future G Protein-Coupled Receptor Genes Genetic Polymorphism Genetic Predisposition to Disease Goals Grant Growth Factor Receptors Head and Neck Cancer Head and Neck Neoplasms Head and Neck Squamous Cell Carcinoma Head and neck structure High-Risk Cancer Histology Human Immune Immune response Immunosuppression Immunotherapeutic agent Immunotherapy In Vitro Incidence Individual Informatics Institution Intervention Knowledge Laboratories Lead Lymphocyte Mediating Medical Medicine Mentors Mentorship Methods Mission Modeling Molecular Molecular Target Monitor Monoclonal Antibodies Morbidity - disease rate Mutation National Institute of Dental and Craniofacial Research Natural Killer Cells Neoadjuvant Therapy Oral Organ Otolaryngology Outcome Participant Pathway interactions Patients Peer Review Peptides Phase Phase I Clinical Trials Phase II Clinical Trials Population Positioning Attribute Postdoctoral Fellow Pre-Clinical Model Predisposition Primary Neoplasm Principal Investigator Proteasome Inhibition Reagent Receptor Signaling Recruitment Activity Regimen Regulator Genes Research Research Activity Research Methodology Research Personnel Research Project Grants Research Training Resistance Resources Risk Risk Assessment Role STAT3 gene Schools Signal Pathway Signal Transduction Signal Transduction Pathway Smoke Solid Neoplasm Source Specialized Program of Research Excellence Subgroup Target Populations Testing Therapeutic Tissue Banking Tissue Banks Training Training Programs Translational Research Treatment outcome United States National Institutes of Health Universities University of Pittsburgh Cancer Institute Vaccines Work alcohol exposure anticancer research base cancer risk career career development clinical practice clinically relevant clinically significant design drinking flexibility genetic risk factor genome wide association study high risk improved in vivo inhibitor/antagonist innovation interdisciplinary approach interest kinase inhibitor malignant mouth neoplasm meetings member minimally invasive mortality neoplastic cell novel novel strategies oncology outcome forecast pre-clinical programs research study response screening src-Family Kinases tobacco exposure treatment response tumor

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中文摘要

翻译

匹兹堡大学提议继续实施一项卓越研究专项计划(SPARE) 在头颈癌方面。匹兹堡头颈部孢子的总体目标是改善头颈部癌症的检测和治疗。孢子程序由四个翻译版本组成头颈癌研究项目，两个研究核心，一个行政核心，一个发展研究计划和职业发展计划。匹兹堡大学头颈孢子将使用跨学科的方法来实现其目标，方法是与联合调查员一起在基础科学、应用科学和临床科学。它也是特定于器官的，因为它的方法和所有项目都将测试关于头颈部癌症生物学、易感性、检测或治疗的假设。长期目标头颈部孢子的研究是根据研究结果进行临床研究的研究项目将作为改善被诊断为头部和脑部疾病患者预后的基础颈癌。四个主要项目包括：(1)途径和GWAS-SNPs：在SCCHN风险、结果中的作用和治疗；(2)抑制STATS信号网络；(3)细胞免疫和免疫逃逸 EGFR抗体治疗；以及(4)共靶向EGFR和Src家族激酶的治疗机制。三个核心将密切互动，以协助主要研究项目、发展研究项目以及开展转化型头颈癌研究的职业发展调查人员。这个研究核心包括：(1)组织学/组织银行和(2)生物统计学和信息学。这个行政核心将征求内部和外部科学咨询委员会的反馈意见为孢子计划提供科学、监管和财政监督。头颈部孢子调查人员将共同努力，协同实现该计划的目标，并将与从其他机构的孢子中提取研究人员以改善头部癌症患者的预后还有脖子。

英文摘要

The University of Pittsburgh proposes to continue a Specialized Program of Research Excellence (SPORE) in Head and Neck Cancer. The overall goals of the Pittsburgh Head and Neck SPORE are to improve the detection, and treatment of head and neck cancer. The SPORE program consists of four translational research projects in head and neck cancer, two research cores, an administrative core, a developmental research program and a career development program. The University of Pittsburgh Head and Neck SPORE will use an interdisciplinary approach to meet its objectives by carrying out projects with co-investigators in basic, applied and clinical science. It is also organ-specific in that its approach and all projects will test hypotheses about head and neck cancer biology, susceptibility, detection, or treatment. The long-term goal of the Head and Neck SPORE is to conduct clinical studies based on research results from the translational research projects that will serve as the basis for improving the outcome of patients diagnosed with head and neck cancer. The four main projects include: (1) Pathway and GWAS-SNPs: Role in SCCHN Risk, Outcome and Treatment; (2) Inhibition of the STATS Signaling Network; (3) Cellular Immunity and Immune Escape for EGFR Antibody Therapy; and (4) Therapeutic Mechanisms of Co-Targeting EGFR and Src Family Kinases. The three cores will interact closely to assist the main research projects, developmental research projects and the career development investigators in carrying out translational head and neck cancer research. The research cores include: (1) Histology/Tissue Banking and (2) Biostatistics and Informatics. The Administrative Core will solicit feedback from the Internal and External Scientific Advisory Boards and provide scientific, regulatory and fiscal oversight for the SPORE program. The Head and Neck SPORE investigators will work together to synergistically achieve the goals of the program and will also interact with investigators from SPOREs at other institutions to improve the outcome of patients with cancer of the head and neck.

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