Core A: Administrative Core

项目摘要--行政核心(核心A) 行政核心(核心A)由HN孢子Pis博士Robert Ferris和Heath Skinner共同领导 丹·赞德伯格博士在希尔曼癌症中心(HCC)财务和行政人员的支持下 由HN孢子和HCC共同支持(见机构承诺书)。初级阶段 核心A的职能是服务于每个项目和核心的行政和监督需求，以及 具体的责任是确保HN孢子的每一个方面都在向其各自的翻译方向发展， 临床或职业提升目标。由于此核心及其相关管理的中心地位 功能，器官特定数据库(OSD)是一个大型的，纵向的，前瞻性的收集，易于搜索， 临床数据库现存放在核心A中，由拥有12,000多个HN孢子的HN孢子直接支持 个别病人和临床记录。Core A主管还将监督来自OSD的数据请求 由于正在进行并将在未来几年内完成的其他“组学”和成像功能的集成 建议的HN孢子期的进程。核心A级董事还将监督核心A级的工作。 临床研究协调员，与机构支持一起，协调HN的临床试验 孢子。核心A联席主任还将促进完整项目、发展项目之间的互动 研究项目、职业提升计划获奖者和核心，确定新的机会和 在HN孢子内进行的每项研究的方向的潜在变化。总而言之，核心A 领导团队监督支出，协调每月HN孢子会议，特邀演讲者，至少两人 执行委员会年度会议、内部和外部咨询委员会会议和孢子间会议 开会。核心A也是所有NCI、机构间和机构外沟通的主要联系点 并协调多个非机构临床试验。此外，核心A协调研究和布局 出版物、网站开发、HNSCC宣传活动、筹款和更多的外联工作 (包括我们与约翰·霍普金斯大学、霍华德大学、埃默里学院和梅哈里学院的外展计划 增加代表不足的少数群体在HN孢子中的参与)。核心A对协调至关重要 HN孢子，特别是确保HN孢子目标的成功完成以及 更广泛地说，在HCC培养一种高度有影响力的翻译研究的持续文化，目标是 改变HNSCC的管理做法。

PROJECT SUMMARY – ADMINISTRATIVE CORE (CORE A) The Administrative Core (Core A) is co-led by HN SPORE PIs Drs. Robert Ferris and Heath Skinner as well as by Dr. Dan Zandberg, with support from the Hillman Cancer Center (HCC) fiscal and administrative staff supported jointly by the HN SPORE and the HCC (see Letter of Institutional Commitment). The primary function of Core A is to serve the administrative and oversight needs of each Project and Core, with the specific responsibility of ensuring each aspect of the HN SPORE is progressing to its individual translational, clinical or career enhancement goal. Due to the centrality of this Core and its associated administrative function, the organ specific database (OSD) a large, longitudinal, prospectively collected, easily searchable, clinical database is now housed in Core A. It is directly supported by the HN SPORE with over 12,000 individual patients and clinical records. The Core A directors will oversee data requests from the OSD as well as the integration of additional ‘’-omics’ and imaging functionality that is ongoing and will be completed over the course of the proposed HN SPORE period. The Core A directors will also oversee the work of the Core A Clinical Research Coordinator who, along with institutional support, coordinates the clinical trials of the HN SPORE. The Core A Co-Directors will also facilitate interactions between full projects, Developmental Research Projects, Career Enhancement Program Awardees, and Cores, identifying new opportunities and potential changes in direction of each study performed within the HN SPORE. Collectively, the Core A leadership team monitor expenditures coordinate monthly HN SPORE meetings, invited speakers, at least bi- annual Executive Committee meetings, Internal and External Advisory Board meetings and Inter-SPORE meetings. Core A is also the primary point of contact for all NCI, inter-and extra-institutional communications and coordinates multi-noninstitutional clinical trials. Additionally, Core A coordinates research and lay publications, website development HNSCC advocacy activities, fund-raising and additional outreach efforts (including our outreach program with Johns Hopkins, Howard University, Emory and Meharry College to increase participation of under-represented minorities in the HN SPORE). Core A is critical to the coordination of the HN SPORE, specifically working to ensure the successful completion of the HN SPORE aims as well as more generally fostering a continued culture of highly impactful translational research at HCC, with a goal of changing practice in the management of HNSCC.