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中文摘要
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项目概要核心1管理核心 行政核心(核心1)将继续监督所有SPORE职能,包括 项目、核心、发展研究方案、职业发展方案和开展的活动 在SPORE合作的支持下。核心确保符合所有地方、联邦和NCI 法规和要求。核心负责与NCI人员的沟通和协商 编写所有必要的报告和出版物。核心负责所有财政和预算 功能协调发展的核心组织所有会议,包括每月的SPORE调查员会议, 执行委员会以及内部和外部科学咨询委员会。核心建立 并监督招募妇女和少数民族作为SPORE试验参与者的政策, 作为孢子调查员核心协调SPORE调查人员参加所有SPORE相关会议的差旅。 核心与发展研究计划和职业发展计划互动, 确保这些SPORE组件的顺利运行。该中心与哥伦比亚大学协调活动, 匹兹堡癌症研究所(UPCI),以避免冗余,并确保UPCI负责人之间的联合活动 头颈癌计划和头颈癌孢子有效地进行, 方案是互补和协同的。行政核心与NCI计划办公室互动, 确保遵守SPORE指南,并执行SPORE计划的任务。 该核心还促进了与UPCI肺癌和皮肤癌SPORE以及新资助的 联合罗斯威尔公园癌症研究所-UPCI卵巢癌孢子,以及头颈癌 其他机构的SPORE计划。在上一个供资期间,核心方案在改变 项目方向,开发新项目,并与内部和外部的投入开展合作, 外部咨询委员会。这些决定导致了这次更新申请中提出的新项目。
英文摘要
Project Summary Core 1 Admin Core The Administrative Core (Core 1) will continue to provide oversight of all SPORE functions including the Projects, Cores, Developmental Research Program, Career Development Program, and activities carried out under the auspices of SPORE collaborations. The Core ensures compliance with all local, federal and NCI regulations and requirements. The Core is responsible for communication and consultation with NCI personnel in the preparation of all required reports and publications. The Core is responsible for all fiscal and budgetary functions. The Core organizes all meetings including the monthly SPORE investigators meeting, meetings with the Executive Committee as well as the Internal and External Scientific Advisory Boards. The Core establishes and monitors policies for the recruitment of women and minorities, both as participants on SPORE trials, and as SPORE investigators. The Core coordinates travel of SPORE investigators to all SPORE-related meetings. The Core interacts with the Developmental Research Program and the Career Development Program to ensure smooth functioning of these SPORE components. The Core coordinates activities with the University of Pittsburgh Cancer Institute (UPCI) to avoid redundancy and ensure that joint activities between the UPCI Head and Neck Cancer Program and the Head and Neck Cancer SPORE are carried out efficiently and that the programs are complementary and synergistic. The Administrative Core interacts with the NCI Program office to ensure that the SPORE guidelines are followed and that the mandate of the SPORE program is carried out. The Core also facilitates collaborations with the UPCI Lung and Skin Cancer SPOREs and the newly funded joint Roswell Park Cancer Institute-UPCI Ovarian Cancer SPORE, as well as the Head and Neck Cancer SPORE programs at other institutions. In the prior funding period, the Core played a key role in changing project directions, developing new projects, and initiating collaborations with input from both the Internal and External Advisory Boards. These decisions led to the new projects proposed in this renewal application.
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Identifying cellular and molecular signatures from distinct T cell receptor clonotypes associated with favorable immune checkpoint inhibitor responses in HNSCCs
Mechanisms of PD-1 and Tim-3 crosstalk in tumor-infiltrating lymphocytes
Mechanisms of PD-1 and Tim-3 crosstalk in tumor-infiltrating lymphocytes
Mechanisms of PD-1 and Tim-3 crosstalk in tumor-infiltrating lymphocytes
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