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Noninvasive Treatment of Biofilm on Metallic Implants

金属植入物上生物膜的无创治疗

基本信息

批准号：
10081060
负责人：
Rajiv Chopra
金额：
$ 58.34万
依托单位：
SOLENIC MEDICAL INC
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-14 至 2022-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10081060
关键词：
Adjuvant Animal Model Antibiotic Resistance Antibiotic Therapy Antibiotics Bacteria Bacterial Drug Resistance Biomedical Engineering Bone Growth Bone Injury Clinical Clinical Trials Collection Communicable Diseases Complement Complication Cyclic GMP Data Data Set Development Devices Documentation Engineering Excision Exposure to Face Feedback Financial Hardship Fright Goals Healthcare Systems Heating Hospitals Human Immune system Implant In Situ In Vitro Incidence Industry Infection Institution Intervention Joint Prosthesis Joints Length of Stay Medical Medical Device Medical center Metals Methods Microbial Biofilms Modeling Morbidity - disease rate Mus Operative Surgical Procedures Orthopedics Outpatients Patients Perioperative Precision therapeutics Procedures Process Prosthesis Pseudomonas aeruginosa Public Health Research Research Personnel Risk Management Safety Scientist Sheep Staphylococcus aureus Surface System Technology Temperature Testing Texas Time Toxic effect Trauma Treatment Failure Universities Validation Veterans antimicrobial antimicrobial drug bactericide base cost design design and construction drug efficacy extracellular in vivo injury and repair innovation joint infection magnetic field medical implant meetings metallicity new technology pathogen portability pre-clinical programs prototype recurrent infection safety testing simulation standard of care synergism

项目摘要

Project Summary Biofilm-related infections are a major complication for orthopedic implants used to replace or repair injured bones and joints. Biofilms are aggregates of bacteria and extracellular substances which can form on any surface, including the surface of implanted medical devices. Bacteria within biofilms are protected from antibiotics and the immune system, and can cause recurrent infection even after a prolonged course of therapy. The treatment of these infections is prolonged and costly; removal and replacement of the infected hardware, weeks of antibiotic administration, and extended hospital stays are usually required. Approximately 70 percent of these biofilm- infections are caused by gram-positive pathogens, such as Staphylococcus aureus, with the remaining caused by gram-negative pathogens, such as Pseudomonas aeruginosa. Increasing rates of antibiotic resistance in these pathogens are further complicating patient treatment. An innovative non-invasive approach for the treatment of biofilm on metallic implants can be achieved through the use of an alternating magnetic fields (AMF). When metal prostheses are exposed to AMF, electrical currents are induced on their surface, resulting in rapid heating which can destroy biofilm. This method of treatment is highly effective at killing the bacterial components of the biofilm, and can be used in concert with traditional antimicrobials to achieve complete treatment of the infection. The research team hypothesizes that focused heating of an in vivo metallic implant surface through the delivery of AMF will be bactericidal to pathogens embedded within an attached biofilm, will increase their sensitivity to antimicrobial agents and will be safe in vivo. The overall goals of this study are to evaluate biofilm eradication by AMF exposure in both small and large animal models of implant infection, as well as design and characterize a prototype AMF device suitable for treating human implant infections. This proposal aims to answer critical questions regarding the optimal power, temperature, and total exposure time that will be both safe and effective. This would represent a significant advance in the ability to treat implants in situ, avoiding millions of surgeries and the corresponding billions of dollars associated with them.

项目总结