Evaluation of MRI-controlled transurethral ultrasound therapy for the treatment o

MRI控制下经尿道超声治疗治疗的评价

• 批准号: 8324925
• 负责人: Rajiv Chopra
• 金额: $ 22.5万
• 依托单位: SUNNYBROOK & WOMEN'S COLL HLTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8324925
• 关键词: Adoption; Age; Biopsy Specimen; Canis familiaris; Clinical; Coagulation Process; Detection; Development; Device or Instrument Development; Devices; Diagnosis; Diagnostic; Diagnostic Imaging; Disease; Ensure; Evaluation; Excision; Future; Gland; Goals; Heating; High Prevalence; High temperature of physical object; Histology; Human; Image; Impairment; Indolent; Intestines; Lead; Left; Lesion; Local Therapy; Location; Magnetic Resonance; Magnetic Resonance Imaging; Malignant Neoplasms; Malignant neoplasm of prostate; Methods; Monitor; Morbidity - disease rate; Normal tissue morphology; Operative Surgical Procedures; Outpatients; PSA screening; Pilot Projects; Procedures; Prostate; Prostatic Neoplasms; Quality of life; Radical Prostatectomy; Research; Research Design; Risk; Schedule; Screening procedure; Specific qualifier value; Staging; Technology; Temperature; Testing; Time; Tissues; Treatment Effectiveness; Ultrasonic Therapy; Urethra; base; cancer diagnosis; cancer therapy; clinically significant; conventional therapy; disorder risk; effective therapy; indexing; insight; men; minimally invasive; new technology; pre-clinical; simulation; tumor; urinary

DESCRIPTION (provided by applicant): Contemporary screening methods for prostate cancer have resulted in an increase in the proportion of men detected with low- to intermediate-risk disease, and a decrease in the average age of detection, compared to previous decades. Unfortunately, current detection methods largely based on biopsy, sample less than 1% of the volume of the prostate and provide little information about the exact location and size of the cancer within the gland. As a result, treatments for localized prostate cancer target the entire prostate gland, which is effective at eliminating disease, but leaves many men with long-term complications to sexual, urinary, and bowel function. Diagnostic imaging with MRI has advanced in recent years to the point where it is possible to see the location and size of tumours within the prostate gland. In addition, the development of new ways to treat prostate cancer under image-guidance offer the promise of more precise treatments with the potential for reduced complications. In this proposal, the ability of MRI-controlled transurethral ultrasound therapy to treat localized prostate cancer will be evaluated. This technology involves treatment (through high temperatures) of specified regions in the prostate gland using high-intensity ultrasound energy delivered from a device inserted into the urethra. The unique feature of this treatment is that it is performed entirely within a magnetic resonance imager, which provides non-invasive images of the temperature within the prostate during heating. This integration of heating and temperature monitoring enables very precise treatment of tissue within the gland. The overall goal of this research is to transform the treatment of localized prostate cancer into a minimally- invasive, outpatient procedure that is as effective as current treatments, but has much lower complications associated with it. The goal of this proposal will be to evaluate the ability of MRI-controlled transurethral ultrasound therapy to effectively treat localized prostate cancer detected with diagnostic MRI. This study will be performed in men scheduled for surgery, so their prostate glands can be studied after removal to evaluate the effectiveness of the treatment. This study design is necessary to ensure a safe evaluation of this novel technology which was tested recently for the first time in humans by our group. If successful, the proposed study will demonstrate the ability of this technology to be used to treat prostate cancer effectively, paving the way for future studies comparing this technology with existing treatments for localized prostate cancer.

描述（由申请人提供）：与前几十年相比，现代前列腺癌筛查方法已导致检测出患有低至中度风险疾病的男性比例增加，并且平均检测年龄下降。不幸的是，当前的检测方法主要基于活检，采样不到前列腺体积的 1%，并且提供的有关腺体内癌症的确切位置和大小的信息很少。因此，局部前列腺癌的治疗以整个前列腺为目标，这可以有效消除疾病，但会给许多男性带来性、泌尿和肠道功能的长期并发症。近年来，MRI 诊断成像已取得进展，可以看到前列腺内肿瘤的位置和大小。此外，在图像引导下治疗前列腺癌的新方法的开发有望提供更精确的治疗，并有可能减少并发症。在该提案中，将评估 MRI 控制的经尿道超声治疗治疗局限性前列腺癌的能力。该技术涉及使用插入尿道的设备传递的高强度超声波能量（通过高温）治疗前列腺的特定区域。这种治疗的独特之处在于它完全在磁共振成像仪内进行，该成像仪可​​提供加热过程中前列腺内温度的非侵入性图像。这种加热和温度监测的集成可以对腺体内的组织进行非常精确的治疗。这项研究的总体目标是将局限性前列腺癌的治疗转变为微创门诊手术，其与当前治疗方法一样有效，但与之相关的并发症要低得多。该提案的目标是评估 MRI 控制的经尿道超声治疗有效治疗诊断 MRI 检测到的局限性前列腺癌的能力。这项研究将在计划接受手术的男性中进行，因此可以在切除后研究他们的前列腺，以评估治疗的有效性。这项研究设计对于确保对这项新技术进行安全评估是必要的，我们的团队最近首次在人体上进行了测试。如果成功，拟议的研究将证明该技术有效治疗前列腺癌的能力，为未来将该技术与局限性前列腺癌现有治疗方法进行比较的研究铺平道路。

项目成果

Spatiotemporal filtering of MR-temperature artifacts arising from bowel motion during transurethral MR-HIFU.

• DOI: 10.1118/1.4897382
• 发表时间: 2014-10
• 期刊: Medical physics
• 影响因子: 3.8
• 作者: A. Schmitt;C. Mougenot;Rajiv Chopra

Coagulation of human prostate volumes with MRI-controlled transurethral ultrasound therapy: results in gel phantoms.

使用 MRI 控制的经尿道超声治疗凝固人类前列腺体积：产生凝胶体模。

• DOI: 10.1118/1.4730288
• 发表时间: 2012
• 期刊: Medical physics
• 影响因子: 3.8
• 作者: N'djin,WilliamApoutou;Burtnyk,Mathieu;Kobelevskiy,Ilya;Hadjis,Stefan;Bronskill,Michael;Chopra,Rajiv
• 通讯作者: Chopra,Rajiv

Development of robust/predictive control strategies for image-guided ablative treatments using a minimally invasive ultrasound applicator.

使用微创超声施用器开发用于图像引导消融治疗的稳健/预测控制策略。

• DOI: 10.3109/02656736.2014.963702
• 发表时间: 2014
• 期刊: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
• 作者: Goharrizi,AminYazdanpanah;Kwong,Raymond;Chopra,Rajiv
• 通讯作者: Chopra,Rajiv

Influence of geometric and material properties on artifacts generated by interventional MRI devices: Relevance to PRF-shift thermometry.

几何和材料特性对介入 MRI 设备产生的伪影的影响：与 PRF 位移测温的相关性。

• DOI: 10.1118/1.4938099
• 发表时间: 2016
• 期刊: Medical physics
• 影响因子: 3.8
• 作者: Tatebe,Ken;Ramsay,Elizabeth;Mougenot,Charles;Kazem,Mohammad;Peikari,Hamed;Bronskill,Michael;Chopra,Rajiv
• 通讯作者: Chopra,Rajiv