Reading and eye-hand coordination in amblyopic children

项目总监/首席调查员(最后、第一、中间)：Kelly、Krista、Rose 项目总结(见说明)： 弱视是儿童单眼视力受损的最常见原因，影响2-3 每100个孩子。弱视通常发生在与双眼不协调的输入相关的时候 在视觉发育过程中有斜视或屈光参差。感觉和眼球运动障碍 在弱视文学中久负盛名。弱视对发育的功能性后果 视觉认知和视觉运动系统鲜为人知。初步研究显示阅读速度慢，细度差 弱视儿童和成人的运动能力，即使他们有一只眼视力正常 在双目观察条件下。然而，人们对这些损伤的原因仍知之甚少。 斜视和屈光参差儿童，有或没有弱视，年龄在4-12岁之间 并与一组正常对照儿童进行比较。将在这些地区开展四个项目 一群群的孩子。阅读过程中的眼球运动将使用Eyelink 1000双眼进行评估 跟踪系统，以及在视觉引导到达点期间和在 视觉引导的精确抓取将使用Eyelink 1000和LEAP运动捕捉进行评估 设备。这些研究将确定感觉缺陷(视力、立体视力、抑制)、眼睛 运动功能障碍(凝视不稳定、异常眼跳)以及视觉规划和指导方面的缺陷 手部运动影响双眼弱视儿童的阅读、伸展和抓握。 拟议中的实验数据将决定异常视觉体验的后果 在视觉认知和视觉运动系统的发展过程中，提供关于感觉和运动的信息 成熟过程中的运动整合，并有助于确定更有效的弱视治疗方法和 让弱视儿童茁壮成长的学术设施。 相关性(请参阅说明)： 弱视儿童阅读缓慢，有轻微的运动障碍。该项目将评估因素 与这些缺陷有关。这些数据将决定异常视觉体验对 开发视觉认知和视觉运动系统，并将指导学校住宿设计 以及促进学业成功的干预措施，并可能为弱视开辟一条新的道路 治疗以克服熟练阅读和熟练的视觉运动技能的障碍。 项目/绩效网站(S)(如果需要额外空间，请使用项目/绩效网站格式页面) 项目/绩效站点主要位置 组织名称：西南视网膜基金会 邓斯：127069466 街1：9600北中央快速街2：200号套房 城市：达拉斯县：美国州：德克萨斯州 省：国家：邮政编码：75206 项目/表演场地国会地区：TX-032 其他项目/绩效站点位置 组织名称： 邓斯： 第一街：第二街： 城市：县：州： 省：国家：邮政编码： 项目/表演场地国会地区： PHS 398(01/18修订版获批准至2020年03/31)OMB编号0925-0001 第2页表单第2页

Program Director/Principal Investigator (Last, First, Middle): Kelly, Krista, Rose PROJECT SUMMARY (See instructions): Amblyopia is the most common cause of monocular vision impairment among children, affecting 2 or 3 of every 100 children. Amblyopia commonly results when there is binocularly discordant input associated with strabismus or anisometropia during visual development. Sensory and ocular motor deficits are well-established in the amblyopia literature. The functional consequences of amblyopia on the developing visuocognitive and visuomotor systems are less known. Initial studies show slow reading and poor fine motor ability in amblyopic children and adults, even when they have one eye with normal visual acuity under binocular viewing conditions. Yet, causes of these impairments remain poorly understood. Strabismic and anisometropic children, with or without amblyopia, between the ages of 4-12 years will be enrolled and compared to a group of normal control children. Four projects will be conducted in these groups of children. Eye movements during reading will be evaluated using the EyeLink 1000 binocular eye tracking system, and temporal eye-hand coordination during visually-guided reach-to-point and during visually-guided precision grasp will be evaluated using the EyeLink 1000 and the LEAP Motion capture device. These studies will determine how sensory deficits (visual acuity, stereoacuity, suppression), ocular motor dysfunction (gaze instability, abnormal saccades), and deficits in visual planning and guidance of hand movements affect reading, reaching, and grasping in amblyopic children under binocular conditions. Data from the proposed experiments will determine the consequences of abnormal visual experience during development on the visuocognitive and visuomotor systems, provide information on sensory and motor integration during maturation, and aid in determining more effective amblyopia treatments and academic accommodations that allow amblyopic children to thrive. RELEVANCE (See instructions): Amblyopic children read slowly and have fine motor impairments. This project will evaluate factors associated with these deficits. These data will determine the effects of abnormal visual experience on developing visuocognitive and visuomotor systems, and will guide the design of school accommodations and interventions to promote academic success,and potentially open a new avenue for amblyopia treatment to surmount obstacles to proficient reading and adept visuomotor skills. PROJECT/PERFORMANCE SITE(S) (if additional space is needed, use Project/Performance Site Format Page) Project/Performance Site Primary Location Organizational Name: Retina Foundation of the Southwest DUNS: 127069466 Street 1: 9600 North Central Expressway Street 2: Suite #200 City: Dallas County: USA State: Texas Province: Country: Zip/Postal Code: 75206 Project/Performance Site Congressional Districts: TX-032 Additional Project/Performance Site Location Organizational Name: DUNS: Street 1: Street 2: City: County: State: Province: Country: Zip/Postal Code: Project/Performance Site Congressional Districts: PHS 398 (Rev. 01/18 Approved Through 03/31/2020) OMB No. 0925-0001 Page 2 Form Page 2