Support for Toxicological Data for the National Toxicology Program Subproject 3 (Support for Biomedical Information Research by NTP)

国家毒理学计划子项目3毒理学数据支持（NTP生物医学信息研究支持）

• 批准号: 10074467
• 负责人: LISA LOPEZ
• 金额: $ 237.82万
• 依托单位: VISTRONIX, INC.
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-12-11 至 2020-12-10
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10074467
• 关键词: Adverse effects; Animal Model; Biological; Chemicals; Collection; Contractor; Contracts; Cultured Cells; Data; Databases; Decision Making; Development; Ensure; Environmental Exposure; Generations; Goals; Government; Government Agencies; Health; Human; Investigation; Knowledge; Metadata; National Institute of Environmental Health Sciences; National Toxicology Program; Outcome; Poison; Policies; Process; Recommendation; Reporting; Research; Research Design; Science; Scientific Advances and Accomplishments; Scientist; Secure; Security; Services; Support Contracts; System; Testing; Toxicology; Visualization; base; carcinogenicity; data acquisition; data integration; data management; data reuse; design; disorder prevention; diverse data; environmental agent; expectation; preservation; programs; reproductive; sound; tool; toxicant; transcriptomics

The objective of the Support for Toxicological Data contract is for Contractor to provide staff with the ability to apply sound scientific and toxicological principles and an intimate knowledge of NTP toxicological study designs to support the acquisition of data from NTP toxicological studies, the integration of the data across studies and toxicological domains, and the presentation of the data in a meaningful format for use in decision-making by NTP scientists, other government agencies and the public at large. The National Toxicology Program (NTP) is an interagency program headquartered at NIEHS and was established by the Secretary of Health and Human Services to provide information about potentially toxic chemicals to regulatory and research agencies and the public, coordinate toxicology research and testing activities and strengthen the science base in toxicology. The Contract supports the data management processes that house NTP data in a secure way compatible with FAIR standards, meaning that the data are Findable, Available, Interpretable and Reusable. The data are stored in an Oracle database and then formatted for reporting by the NTP. Metadata (data about the data) are captured in Oracle and shared. The Contract also supports user access to these data for cross-study queries and other investigations. Contract supports the design, development and delivery of tools to access and query data. Contractor adheres to security policy of the government and ensures that predecisional data are secure and available only to authorized users. NTP uses a LIMS system, NTP Provantis, to collect data and Contract provides scientific advice to NTP and contract staff about using NTP Provantis in alignment with NTP Expectations.

毒理学数据支持合同的目的是让承包商为员工提供应用合理的科学和毒理学原则的能力，以及NTP毒理学研究设计的深入知识，以支持从NTP毒理学研究中获取数据，整合研究和毒理学领域的数据，并以有意义的格式提供数据，供国家结核病规划科学家、其他政府机构和广大公众在决策中使用。 国家毒理学计划（NTP）是一个机构间计划，总部设在NIEHS，由卫生和人类服务部部长建立，旨在向监管和研究机构以及公众提供有关潜在有毒化学品的信息，协调毒理学研究和测试活动，并加强毒理学的科学基础。 该合同支持数据管理流程，以与FAIR标准兼容的安全方式存储NTP数据，这意味着数据是可查找的，可用的，可解释的和可重用的。 数据存储在Oracle数据库中，然后格式化以供NTP报告。 元数据（关于数据的数据）在Oracle中捕获并共享。 该合同还支持用户访问这些数据，以进行交叉研究查询和其他调查。 Contract支持访问和查询数据的工具的设计、开发和交付。 承包商遵守政府的安全政策，并确保决策前的数据是安全的，只提供给授权用户。 NTP使用LIMS系统NTP Provantis收集数据，并向NTP和合同员工提供有关使用NTP Provantis符合NTP预期的科学建议。