Support for Toxicological Data for the National Toxicology Program Subproject 2 (Support for Cancer Research by NTP)

国家毒理学计划子项目2的毒理学数据支持（NTP对癌症研究的支持）

• 批准号: 10329846
• 负责人: LISA LOPEZ
• 金额: $ 100万
• 依托单位: VISTRONIX INC
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-12-11 至 2021-06-10
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10329846
• 关键词: Adverse effects; Biological; Chemicals; Code; Collection; Contractor; Contracts; Data; Data Store; Databases; Decision Making; Development; Ensure; Environmental Exposure; Generations; Goals; Government; Government Agencies; Health; Human; Incidence; Investigation; Knowledge; Laboratories; Malignant Neoplasms; Metadata; Methods; National Institute of Environmental Health Sciences; National Toxicology Program; Outcome; Poison; Policies; Process; Publications; Regulation; Reporting; Research; Research Design; Science; Scientist; Secure; Security; Services; Statistical Data Interpretation; Support Contracts; System; Testing; Toxicology; Training; United States Food and Drug Administration; Validation; Visualization; anticancer research; base; data acquisition; data integration; data management; data reuse; design; disorder prevention; expectation; good laboratory practice; preservation; programs; sound; tool; toxicant

The objective of the Support for Toxicological Data contract is for Contractor to provide staff with the ability to apply sound scientific and toxicological principles and an intimate knowledge of NTP toxicological study designs to support the acquisition of data from NTP toxicological studies, the integration of the data across studies and toxicological domains, and the presentation of the data in a meaningful format for use in decision-making by NTP scientists, other government agencies and the public at large. The National Toxicology Program (NTP) is an interagency program headquartered at NIEHS and was established by the Secretary of Health and Human Services to provide information about potentially toxic chemicals to regulatory and research agencies and the public, coordinate toxicology research and testing activities and strengthen the science base in toxicology. The Contract supports the data management processes that house NTP data in a secure way compatible with FAIR standards, meaning that the data are Findable, Available, Interpretable and Reusable. The data are stored in an Oracle database and then formatted for reporting by the NTP. Metadata (data about the data) are captured in Oracle and shared. The Contract also supports user access to these data for cross-study queries and other investigations. Contract supports the design, development and delivery of tools to access and query data. Contractor adheres to security policy of the government and ensures that predecisional data are secure and available only to authorized users. NTP uses a LIMS system, NTP Provantis, to collect data and Contract provides scientific advice to NTP and contract staff about using NTP Provantis in alignment with NTP Expectations.

毒理学数据支持合同的目标是让承包商为工作人员提供应用健全的科学和毒理学原则的能力，以及对NTP毒理学研究设计的深入了解，以支持从NTP毒理学研究中获取数据，跨研究和毒理学领域的数据整合，并以有意义的格式呈现数据，供NTP科学家在决策中使用。其他政府机构和广大公众。