Translational Genomics and Precision Medicine in Cancer Training Program

项目总结 迫切需要培养下一代转化型癌症研究人员，以适应 基因组医学和大数据。我们必须确保科学家在最需要的领域接受培训 将数据和实验转化为临床实践。这项建议建立在现有的跨学科基础上。 在MD安德森癌症中心开发的教育和研究培训计划，在那里我们有一个 消除癌症使命，以扩大和加强对优秀博士后和 使用以核心为中心的创新课程和多学科方法的博士后研究员 翻译研究前沿领域的能力。 目标：1)在对未来具有重要意义的领域提供既有深度又有广度的全面计划 翻译癌症研究，包括翻译基因组学和精确医学方法，早期 癌症的检测和预后以及诊断应用；2)招聘顶尖博士前和 对这一领域的转化性癌症研究感兴趣的博士后研究员；3)为研究员提供 创新的环境、基础设施、师资和行政支持，使他们能够 为该领域做出贡献，并进一步履行MD安德森癌症中心的使命。 理论基础：癌症翻译基因组学和精确医学(TGP)培训计划：TGP 该计划将提供必要的教育和培训以及基础设施和监督，以发展 创新的大数据基因组科学家。竞争激烈的遴选过程将评选出优秀的 并确保这一过程中的多样性。合格的候选人，除了有指导的研究 我们一位杰出的培训资助教师的经验将在以下方面获得个性化的跨学科培训 核心能力领域对后基因组世界中翻译科学的未来至关重要。 T32项目设计：T32将提供围绕核心设计的3个博士后和1个博士后奖学金 能力包括：1)转化型癌症研究，接触机械研究 翻译研究及其对人体的重要性；2)精准医学在以下方面获得经验 诊断和治疗癌症患者的最先进方法；3)翻译遗传学和基因组学将获得 理解和实施癌症精确医学的能力；4)生物信息学，学习如何 阅读和解释大型数据集；以及5)接触临床大查房、肿瘤委员会和工业 合作。主要活动包括：赠款撰写研讨会、NIH赠款开发和重点指导。 所有受训人员将被要求对癌症研究有浓厚的兴趣，对于博士后，经验 癌症研究。博士后的培训期限为2年，博士后研究员的培训期限最长为3年 与德克萨斯大学MD安德森癌症中心和德克萨斯大学生物医学研究生院合作的培训教师 科学。

PROJECT SUMMARY There is a critical need to train the next generation of translational cancer researchers in light of a new era of genomic medicine and big data. We must ensure that scientists are trained in the areas of highest need for translation of data and experiments into clinical practice. This proposal builds on an existing interdisciplinary education and research training program developed at MD Anderson Cancer Center, where we have a single mission to eliminate cancer, in order to expand and enhance the training of outstanding predoctoral and postdoctoral fellows using an innovative curriculum and multidisciplinary approach centered on core competencies in state-of-the-art areas of translational research. Objectives: 1) to provide a comprehensive program with both depth and breadth in areas important to the future of translational cancer research including translational genomics and precision medicine approaches, early detection and prognosis of cancer, as well as diagnostic applications; 2) to recruit top predoctoral and postdoctoral fellows interested in a career in translational cancer research in this area; 3) to provide fellows with an innovative environment, infrastructure, faculty and administrative support to allow them to make significant contributions to the field and further the mission of the MD Anderson Cancer Center. Rationale: Translational Genomics and Precision Medicine in Cancer (TGP) Training Program: The TGP program will provide the necessary education and training as well as infrastructure and oversight to develop innovative, big data genome scientists. A highly competitive selection process will identify outstanding candidates and ensure diversity in the process. Qualified candidates, in addition to a mentored research experience by one of our outstanding training grant faculty, will gain individualized, interdisciplinary training in core competency areas critical to the future of translational science in a postgenome world. Design of T32 Program: The T32 will offer 3 postdoctoral and 1 predoctoral fellowships designed around core competencies which include: 1) translational cancer research, to gain exposure to mechanistic studies in translational research and their importance to the human organism; 2) precision medicine to gain experience in state-of-the-art approaches to diagnose and treat cancer patients; 3) translational genetics and genomics to gain competency in understanding and implementation of cancer precision medicine; 4) bioinformatics, to learn how to read and interpret large datasets; and 5) exposure to clinical grand rounds, tumor boards, and industrial collaborations. Key activities include: grant writing workshops, NIH grant development, and focused mentoring. All trainees will be required to have strong interest in cancer research and for postdoctorates, experience in cancer research. Training duration will be 2 years for postdoctoral and up to 3 years for predoctoral fellows with training faculty associated with UT MD Anderson Cancer Center and with the UT Graduate School of Biomedical Sciences.