Translational Genomics and Precision Medicine in Cancer Training Program

癌症转化基因组学和精准医学培训计划

• 批准号: 10112836
• 负责人: ANN M KILLARY
• 金额: $ 18.52万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10112836
• 关键词: Genomic medicine; Malignant Neoplasms; Training Programs; precision medicine; translational genomics

PROJECT SUMMARY There is a critical need to train the next generation of translational cancer researchers in light of a new era of genomic medicine and big data. We must ensure that scientists are trained in the areas of highest need for translation of data and experiments into clinical practice. This proposal builds on an existing interdisciplinary education and research training program developed at MD Anderson Cancer Center, where we have a single mission to eliminate cancer, in order to expand and enhance the training of outstanding predoctoral and postdoctoral fellows using an innovative curriculum and multidisciplinary approach centered on core competencies in state-of-the-art areas of translational research. Objectives: 1) to provide a comprehensive program with both depth and breadth in areas important to the future of translational cancer research including translational genomics and precision medicine approaches, early detection and prognosis of cancer, as well as diagnostic applications; 2) to recruit top predoctoral and postdoctoral fellows interested in a career in translational cancer research in this area; 3) to provide fellows with an innovative environment, infrastructure, faculty and administrative support to allow them to make significant contributions to the field and further the mission of the MD Anderson Cancer Center. Rationale: Translational Genomics and Precision Medicine in Cancer (TGP) Training Program: The TGP program will provide the necessary education and training as well as infrastructure and oversight to develop innovative, big data genome scientists. A highly competitive selection process will identify outstanding candidates and ensure diversity in the process. Qualified candidates, in addition to a mentored research experience by one of our outstanding training grant faculty, will gain individualized, interdisciplinary training in core competency areas critical to the future of translational science in a postgenome world. Design of T32 Program: The T32 will offer 3 postdoctoral and 1 predoctoral fellowships designed around core competencies which include: 1) translational cancer research, to gain exposure to mechanistic studies in translational research and their importance to the human organism; 2) precision medicine to gain experience in state-of-the-art approaches to diagnose and treat cancer patients; 3) translational genetics and genomics to gain competency in understanding and implementation of cancer precision medicine; 4) bioinformatics, to learn how to read and interpret large datasets; and 5) exposure to clinical grand rounds, tumor boards, and industrial collaborations. Key activities include: grant writing workshops, NIH grant development, and focused mentoring. All trainees will be required to have strong interest in cancer research and for postdoctorates, experience in cancer research. Training duration will be 2 years for postdoctoral and up to 3 years for predoctoral fellows with training faculty associated with UT MD Anderson Cancer Center and with the UT Graduate School of Biomedical Sciences.

项目摘要 在癌症研究的新时代，迫切需要培养下一代的转化癌症研究人员。 基因组医学和大数据。我们必须确保科学家在最需要的领域得到培训， 将数据和实验转化为临床实践。这一建议建立在现有的跨学科 MD安德森癌症中心开发的教育和研究培训计划，在那里我们有一个单一的 使命，以消除癌症，以扩大和加强优秀的博士前和 博士后研究员使用创新的课程和多学科的方法为中心的核心 在国家的翻译研究的最先进的领域的能力。 目标：1）在对未来重要的领域提供深度和广度的综合方案 包括转化基因组学和精准医学方法在内的转化癌症研究， 癌症的检测和预后，以及诊断应用; 2）招募顶尖的博士前和 对这一领域的转化癌症研究感兴趣的博士后研究员; 3）为研究员提供 一个创新的环境，基础设施，教师和行政支持，使他们能够做出重大 对该领域的贡献和进一步的安德森癌症中心的使命。 翻译基因组学与癌症精准医学（TGP）培训项目：TGP 该计划将提供必要的教育和培训以及基础设施和监督，以发展 创新的大数据基因组科学家一个高度竞争的选拔过程将确定杰出的 确保候选人的多样性。合格的候选人，除了指导研究 我们的优秀培训补助金教师之一的经验，将获得个性化，跨学科的培训， 核心竞争力领域对后基因组世界中转化科学的未来至关重要。 T32计划的设计：T32将提供围绕核心设计的3个博士后和1个博士前奖学金 能力包括：1）转化癌症研究，以获得接触机制研究， 转化研究及其对人体组织的重要性; 2）精准医学，以获得经验， 最先进的方法来诊断和治疗癌症患者; 3）翻译遗传学和基因组学，以获得 理解和实施癌症精准医学的能力; 4）生物信息学，学习如何 阅读和解释大型数据集;和5）接触临床大轮，肿瘤委员会，和工业 合作。主要活动包括：赠款写作研讨会，NIH赠款开发和重点指导。 所有学员将被要求对癌症研究有浓厚的兴趣，对于博士后， 癌症研究。博士后培训时间为2年，博士前研究员培训时间为3年， 与UT MD安德森癌症中心和UT生物医学研究生院相关的培训教师 以理工科为重