Testing the feasibility and preliminary efficacy of a multilevel intervention to promote physical activity among patients with metabolic syndrome

测试多层次干预促进代谢综合征患者体力活动的可行性和初步效果

基本信息

  • 批准号:
    10112949
  • 负责人:
  • 金额:
    $ 16.66万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2017
  • 资助国家:
    美国
  • 起止时间:
    2017-02-01 至 2023-01-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY/ ABSTRACT Candidate. I am a psychology post-doctoral research and clinical fellow with the Massachusetts General Hospital Cardiac Psychiatry Research Program. I hold a PhD in clinical health psychology and a master of health science (MHS) degree in epidemiology. I have first- or co-authored 26 peer-reviewed publications focusing on individual, group, and community-based strategies for physical activity and nutrition promotion, obesity and chronic disease prevention, and the intersection of mental and physical health. My short-term career goals are to develop and refine my clinical research skills with a focus on physical activity promotion. I plan to develop the skills I need to lead a clinical research program by pursuing this K23 award. This award would support my long-term career goals by providing me with the skills to become an independent researcher focused on developing novel interventions to promote physical activity for chronic disease prevention. If the proposed intervention proves successful, it will provide data to pursue future research using this intervention, thereby building the evidence base for patient-oriented multilevel physical activity interventions. Career Development. I will develop this intervention based on relevant theory, patient input, and expertise from my mentorship team: Dr. Jeff Huffman (clinical research, positive psychology), Dr. Elyse Park (qualitative research, motivational interviewing), Dr. Anne Thorndike (metabolic syndrome, environmental interventions), and Dr. Brian Healy (biostatistics). My team consultants, Dr. I-Min Lee (physical activity, measurement) and Dr. Lisa Quintilliani (community-based research, dissemination and implementation) will provide further expertise to support my training goals and research plan. The intervention development, testing, and dissemination process, along with relevant coursework, seminars, and workshops, will support my four training goals: 1) developing analytic skills for qualitative, clinical, and multilevel data, 2) becoming an expert in metabolic syndrome risk and prevention, 3) learning cutting-edge and technology-based physical activity and sedentary behavior measurement, and 4) dissemination and implementation of research findings. Environment. I will conduct this project at Massachusetts General Hospital (MGH), a Harvard Medical School teaching hospital, using its extensive resources for training and supporting clinical researchers and performing top-quality research. The MGH Cardiac Psychiatry Research Program (CPRP), my current research group, will be the primary setting for this award. Led by my primary mentor, Dr. Huffman, the group has performed numerous health promotion trials in patients with cardiovascular disease and diabetes. The CPRP is actively enrolling participants for five trials, including an NHLBI-funded R01 treatment development trial of positive psychology and motivational interviewing in cardiac patients. I will recruit patients from two primary care clinics that are actively engaged in research. I will also collaborate with the MGH Behavioral Medicine Service, a large research and clinical program that aims to develop and validate behavioral interventions for individuals with medical illness. The MGH Clinical Research Program and Harvard Catalyst programs will also support my proposed project with clinical research consulting services, seminars and courses on the responsible conduct of research, IRB preparation, and using HIPAA and research-compliant electronic data capture software. Research development and design. The overall aim of this project is to develop and test a behavioral intervention to increase physical activity among patients with metabolic syndrome (MetS) who are insufficiently active. MetS affects about 34% of US adults and is comprised of five cardio-metabolic risk factors that are strongly associated with an increased risk of type 2 diabetes, cardiovascular disease, and related mortality. Physical activity plays a key role in preventing progression from MetS to these diseases, but a majority of people with MetS risk factors do not meet physical activity recommendations. The goal of this project is to identify insufficiently active primary care patients with MetS risk factors and help them increase their physical activity by creating a multilevel intervention addressing targets at the individual, social, and environmental levels. This project will develop and test a combined positive psychology and motivational interviewing intervention in a group setting and have participants complete a neighborhood walkability assessment. I plan to follow the NIH-supported ORBIT model for health behavior change intervention development to create the intervention in three phases: 1) qualitative research and intervention development (N=20), 2) a feasibility pilot trial and intervention refinement (N=16), and 3) a small randomized controlled trial (N=64). The specific aims are to sequentially develop the intervention and test its feasibility, acceptability, and preliminary clinical impact. The hypotheses are that this intervention i) will be feasible and acceptable, and ii) that patients in the intervention group will increase their physical activity, positive emotions, and related health behaviors, more than an enhanced usual care control group. This study’s aims will address important research gaps by systematically, iteratively developing a multilevel (individual, social, and environmental) physical activity intervention customized for MetS. Each study aim addresses one or more of my training goals and allows me to use the breadth of resources available at MGH and Harvard to become proficient in leading clinical trials that have a public health impact.
项目摘要/摘要 候选人。我是马萨诸塞州总医院的心理学博士后研究和临床研究员 医院心脏精神病学研究计划。我拥有临床健康心理学博士学位和硕士学位。 流行病学健康科学(MHS)学位。我第一次或与人合著了26本同行评议的出版物 注重以个人、团体和社区为基础的体育活动和营养促进战略, 肥胖和慢性病的预防,以及心理和身体健康的交集。我的短期 职业目标是发展和完善我的临床研究技能,重点是促进身体活动。我 计划通过追求这个K23奖项来发展我领导临床研究项目所需的技能。本奖项 通过为我提供成为一名独立研究人员的技能来支持我的长期职业目标 重点是开发新的干预措施,以促进慢性病预防的体力活动。如果 建议的干预措施被证明是成功的,它将为未来使用这种干预措施进行研究提供数据, 从而为以患者为导向的多层次体力活动干预提供证据基础。 职业发展。我将根据相关理论、患者意见和专业知识制定干预措施 来自我的指导团队:Jeff Huffman博士(临床研究,积极心理学),Elyse Park博士(定性 研究,动机访谈),Anne Thorndike博士(代谢综合征,环境干预), 以及布莱恩·希利博士(生物统计学)。我的团队顾问李益民博士(体力活动、测量)和Dr。 Lisa Quintilliani(基于社区的研究、传播和实施)将提供进一步的专业知识 支持我的培训目标和研究计划。干预措施的开发、测试和传播 流程,以及相关的课程、研讨会和研讨会,将支持我的四个培训目标:1) 培养定性、临床和多层次数据的分析技能,2)成为代谢专家 综合症风险和预防,3)学习尖端和以技术为基础的体力活动和久坐 行为测量,以及4)研究成果的传播和实施。 环境我将在马萨诸塞州综合医院(MGH)进行这个项目,这是一家哈佛医学院 学校教学医院,利用其广泛的资源培训和支持临床研究人员和 进行一流的研究。MGH心脏精神病学研究计划(CPRP),我目前 研究小组,将是这一奖项的主要背景。在我的主要导师赫夫曼博士的带领下,这个小组 在心血管疾病和糖尿病患者中进行了大量的健康促进试验。这个 CPRP正在积极招募参与者参加五项试验,其中包括由NHLBI资助的R01治疗开发 积极心理学和激励性访谈在心脏病患者中的尝试。我会从两个人中招募病人 积极从事研究的初级保健诊所。我还将与MGH Behaviative合作 医学服务,一个大型研究和临床项目,旨在开发和验证行为 对患有内科疾病的个人进行干预。MGH临床研究计划与哈佛大学催化剂 计划还将通过临床研究咨询服务、研讨会和 关于负责任地进行研究、IRB准备以及使用HIPAA和符合研究的课程 电子数据捕获软件。 研究、开发和设计。该项目的总体目标是开发和测试行为 增加代谢综合征(METS)患者体力活动的干预措施 激活。甲硫氨酸影响了大约34%的美国成年人,它由五个心脏代谢风险因素组成,它们是 与2型糖尿病、心血管疾病和相关死亡率的风险增加密切相关。 体力活动在防止METs发展为这些疾病方面起着关键作用,但大多数 患有METS风险因素的人不符合体力活动建议。 该项目的目标是确定活动不足的初级保健患者的METS风险因素和 通过创建针对目标的多层次干预,帮助他们增加体力活动 个人、社会和环境层面。该项目将开发和测试一种组合的积极心理学 以及小组环境中的激励性访谈干预,并让参与者完成一个社区 步行能力评估。我计划遵循美国国立卫生研究院支持的健康行为改变轨道模型 干预的发展分为三个阶段:1)定性研究和干预 开发(N=20),2)可行性先导试验和干预改进(N=16),以及3)小规模随机 对照试验(N=)。具体目标是按顺序开展干预并测试其可行性, 可接受性和初步临床影响。假设是这种干预i)将是可行的, 可以接受,以及ii)干预组的患者将增加他们的体力活动,积极的情绪, 及相关健康行为方面,均优于常规护理对照组。 这项研究的目标将通过系统地、迭代地开发多水平的 (个人、社会和环境)为大都会运动队定制的体力活动干预。每个研究目标 满足我的一个或多个培训目标,并允许我使用MGH可用的广泛资源 和哈佛大学精通对公共健康有影响的领先临床试验。

项目成果

期刊论文数量(20)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
A community-based positive psychology group intervention to promote physical activity among people with metabolic syndrome: Proof of concept results to inform a pilot randomized controlled trial protocol.
以社区为基础的积极心理学团体干预措施,以促进代谢综合征患者的身体活动:概念验证结果为试点随机对照试验方案提供信息。
  • DOI:
    10.1016/j.conctc.2020.100626
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    1.5
  • 作者:
    Millstein,RachelA;Thorndike,AnneN;Kim,Sonia;Park,ElyseR;Huffman,JeffC
  • 通讯作者:
    Huffman,JeffC
An Exploration of Health Behaviors in a Mind-Body Resilience Intervention for Parents of Children with Developmental Disabilities.
A positive psychology-motivational interviewing intervention for patients with type 2 diabetes: Proof-of-concept trial.
The Need for Local, Multidisciplinary Collaborations to Promote Advances in Physical Activity Research and Policy Change: The Creation of the Boston Physical Activity Resource Collaborative (BPARC).
需要地方、多学科合作来促进体育活动研究和政策变革的进步:波士顿体育活动资源协作组织 (BPARC) 的创建。
  • DOI:
    10.12691/jpar-3-2-2
  • 发表时间:
    2018
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Millstein,RachelA;Oreskovic,NicolasM;Quintiliani,LisaM;James,Peter;Intille,Stephen
  • 通讯作者:
    Intille,Stephen
A secondary analysis examining the performance of the State Optimism Measure (SOM) compared to the Life Orientation Test-Revised (LOT-R) in measuring optimism over time.
二次分析检查了状态乐观测量 (SOM) 与修订后的生活取向测试 (LOT-R) 在测量乐观情绪方面的表现。
  • DOI:
    10.1080/08870446.2022.2126472
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    3.3
  • 作者:
    Hoeppner,SusanneS;Millstein,RachelA;Siegel,KaitlynR;Carlon,HannahA;Harnedy,LaurenE;Chung,Wei-Jean;Huffman,JeffC;Hoeppner,BettinaB
  • 通讯作者:
    Hoeppner,BettinaB
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Rachel A. Millstein其他文献

An Online Resilience Intervention for Military Personnel
针对军事人员的在线弹性干预
  • DOI:
    10.3928/00485713-20220513-01
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    0.5
  • 作者:
    Rachel A. Millstein;Megan D McCarthy;R. Chudnofsky;Stacie Fredriksson;Jacque Francona;Tricia Winklosky;Brian Sampson;Ariel Mulzoff;Ronald E. Hirschberg;E. Park;G. Fricchione;D. Mehta;J. Denninger;L. Sylvia
  • 通讯作者:
    L. Sylvia
Attributional Style
归因风格
  • DOI:
    10.1007/978-1-4419-1005-9_100131
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    0
  • 作者:
    D. Abrams;J. Turner;L. Baumann;A. Karel;S. E. Collins;K. Witkiewitz;T. Fulmer;M. Tanenbaum;P. Commissariat;Elyse G. Kupperman;Rachel N. Baek;Jeffrey S. Gonzalez;Nicole Brandt;Rachel W. Flurie;J. Heaney;Christopher Kline;Linda Carroll;Janet Upton;P. Buchain;A. Vizzotto;Alexandra Martini de Oliveira;Tania C. T. Ferraz Alves;Quirino Cordeiro;Lorenzo Cohen;M. K. Garcia;Amy Jo Marcano;S. Ye;Y. Gidron;M. Gellman;M. Howren;M. Harlapur;D. Shimbo;Keisuke Ohta;N. Yahagi;E. Franzmann;Abanish Singh;Debra L Johnson;Benjamin L. Clarke;Rachel A. Millstein;Karen Niven;E. Miles;Barbara Resnick;Carter A. Lennon;Kelly S. DeMartini;K. L. MacGregor;M. Kirouac;Yoshiharu Yamamoto;U. Nater;Nicole L Nisly;D. Johnston;Y. Zanstra;Youngmee Kim;D. Matheson;Brooke McInroy;C. France;S. Fukudo;Emiko Tsuchiya;Yoko Katayori;Martin Deschner;Norman B. Anderson;Chad E. Barrett;M. Lumley;Lindsay Oberleitner;S. Bongard;Seth Hurley;A. M. Patiño;Anna C. Phillips;T. Akechi;S. Aldred;Kim Lavoie;Kate L. Jansen;Katherine Fortenberry;Molly S. Clark;T. Okuyama;W. Whang;M. al’Absi;Bingshuo Li;Elizabeth R. Pulgaron;Diana Wile;Beth A. Schroeder;Mary C Davis;A. Zautra;S. L. Stark;A. V. Soto;Anthony J. Wheeler;S. DeBerard;Josh W. Allen;A. Mitani;Jennifer Carter;Angela M. Hicks;Carolyn D Korbel;Austin S. Baldwin;K. Spink;Darren Nickel;M. Richter;R. Wright;Julian F. Thayer;D. Wiebe
  • 通讯作者:
    D. Wiebe
Youth Advocacy for Obesity Prevention: Measurement Evaluation, Mediators of Advocacy Readiness and Receptivity, and Processes of Policy Change
预防肥胖的青年倡导:测量评估、倡导准备度和接受度的中介因素以及政策变化的过程
A Pilot Study of a Stress Management Program for Incarcerated Veterans.
被监禁退伍军人压力管理计划的试点研究。
  • DOI:
    10.1093/milmed/usab121
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    1.2
  • 作者:
    L. Sylvia;R. Chudnofsky;Stacie Fredriksson;Bingyu Xu;Megan D McCarthy;Jacque Francona;B. R. Hart;Rachel A. Millstein;D. Mehta;E. Park;G. Fricchione
  • 通讯作者:
    G. Fricchione
Cognitive-Behavioral Management of Obesity
肥胖的认知行为管理
  • DOI:
  • 发表时间:
    2017
  • 期刊:
  • 影响因子:
    0
  • 作者:
    N. Reilly;Stephanie Sogg;Rachel A. Millstein;M. Gorman
  • 通讯作者:
    M. Gorman

Rachel A. Millstein的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Rachel A. Millstein', 18)}}的其他基金

Testing the feasibility and preliminary efficacy of a multilevel intervention to promote physical activity among patients with metabolic syndrome
测试多层次干预促进代谢综合征患者体力活动的可行性和初步效果
  • 批准号:
    9417958
  • 财政年份:
    2017
  • 资助金额:
    $ 16.66万
  • 项目类别:

相似海外基金

Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
  • 批准号:
    MR/S03398X/2
  • 财政年份:
    2024
  • 资助金额:
    $ 16.66万
  • 项目类别:
    Fellowship
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
  • 批准号:
    2338423
  • 财政年份:
    2024
  • 资助金额:
    $ 16.66万
  • 项目类别:
    Continuing Grant
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
  • 批准号:
    EP/Y001486/1
  • 财政年份:
    2024
  • 资助金额:
    $ 16.66万
  • 项目类别:
    Research Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
  • 批准号:
    MR/X03657X/1
  • 财政年份:
    2024
  • 资助金额:
    $ 16.66万
  • 项目类别:
    Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
  • 批准号:
    2348066
  • 财政年份:
    2024
  • 资助金额:
    $ 16.66万
  • 项目类别:
    Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
  • 批准号:
    AH/Z505481/1
  • 财政年份:
    2024
  • 资助金额:
    $ 16.66万
  • 项目类别:
    Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10107647
  • 财政年份:
    2024
  • 资助金额:
    $ 16.66万
  • 项目类别:
    EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
  • 批准号:
    2341402
  • 财政年份:
    2024
  • 资助金额:
    $ 16.66万
  • 项目类别:
    Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10106221
  • 财政年份:
    2024
  • 资助金额:
    $ 16.66万
  • 项目类别:
    EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
  • 批准号:
    AH/Z505341/1
  • 财政年份:
    2024
  • 资助金额:
    $ 16.66万
  • 项目类别:
    Research Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了