Enhancing basic and translational TB research in northern Vietnam

加强越南北部的基础和转化结核病研究

• 批准号: 10115836
• 负责人: Brian Thacher Murphy
• 金额: $ 21.59万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10115836
• 关键词: AIDS/HIV problem; Academy; Antibiotics; Basic Science; Biochemistry; Biodiversity; Biological Assay; Centers for Disease Control and Prevention (U.S.); Cessation of life; Chicago; Clinical; Collaborations; Complement; Country; Development; Disease; Drug resistance in tuberculosis; Epidemiology; Foundations; Funding; HIV Seropositivity; Hygiene; Illinois; In Vitro; Infrastructure; Institutes; Institution; Lead; Medical; Mycobacterium tuberculosis; Natural Resources; Pathogenicity; Pharmaceutical Preparations; Plants; Research; Research Infrastructure; Research Personnel; Research Training; Resources; Science; Scientist; Students; System; Technology; Training; Training Programs; Training and Education; Translational Research; Tuberculosis; United States National Institutes of Health; Universities; Vietnam; Work; World Health Organization; base; post-doctoral training; pre-doctoral; programs; screening; screening program; success

In 2014, the World Health Organization estimated that there were 1.5 million deaths as a result of Mycobacterium tuberculosis (TB) infection (0.4 million of which were HIV-positive). Vietnam is located in a region that accounts for 58% of the world's TB cases, and an estimated 137,000 Vietnamese are infected with TB per year (5,000 of which acquire drug-resistant TB). Of these, the disease kills an estimated 19,000 Vietnamese annually. In the current proposal, we aim to enhance and strengthen a research training program between the University of Illinois at Chicago (UIC), the Institute of Marine Biochemistry at the Vietnam Academy of Science and Technology (IMBC-VAST), and the National Institute of Hygiene and Epidemiology (NIHE) in Hanoi, Vietnam. We aim to enhance host country basic and translational research capacity that focuses on the discovery and development of antibiotic leads for TB. Since the 1990s, the Centers for Disease Control and Prevention have invested heavily in both clinical labs and HIV/AIDS/TB surveillance systems in Vietnam, though these and several other efforts have focused predominantly on building medical infrastructure. Our proposal will bridge this gap by enhancing basic and translational science research infrastructure and a researcher training program that focuses on utilizing host-country resources to discover antibiotic leads that will treat TB and probe its basic mechanisms of pathogenicity through coordinated antibiotic lead screening programs in Hanoi. The success of this program is driven by short- and long-term research training and education. UIC has a strong track record of collaboration with VAST. Through NIH and MacArthur Foundation funding in the past 20 years, the team has worked to build a plant-based drug-lead discovery and resource conservation program. However, with greater than 3,000 km of coastline, Vietnam harbors some of the richest marine biodiversity in the world, from which this proposal aims to mine. The aims of this program are 1) Establish three independent investigators at IMBC-VAST/NIHE via long-term postdoctoral training at UIC; 2) Provide short- and long-term antibiotic-specific training to nine IMBC/NIHE predoctoral students over the course of the program period; 3) Enhance biological assay research infrastructure through creation of an in vitro M. tuberculosis screening program at NIHE. In a five-year period, our program will generate twelve highly trained scientists who specialize in TB antibiotic discovery and development. Three of the twelve scientists – with considerable institutional support from the Director and President of their respective institutes – will establish independent research groups that complement a broader program that uses Vietnam's natural resources to discover TB antibiotics, and to use these leads to explore mechanisms of M. tuberculosis pathogenicity. Beyond the five-year project period, the significant enhancement in research capacity at IMBC and NIHE will establish northern Vietnam as a translational screening center for TB, and will facilitate collaboration with institutions across and outside Vietnam.

2014年，世界卫生组织估计有150万人死于结核分枝杆菌感染（其中40万人为艾滋病毒阳性）。越南所在的地区占世界结核病病例的58%，估计每年有13.7万越南人感染结核病（其中5000人获得耐药结核病）。其中，估计每年有19,000名越南人死于该疾病。在目前的提案中，我们的目标是加强和加强伊利诺伊大学芝加哥分校（UIC）、越南科学技术研究院海洋生物化学研究所（IMBC-VAST）和越南河内国家卫生与流行病学研究所（NIHE）之间的研究培训计划。我们的目标是加强东道国的基础研究和转化研究能力，重点是发现和开发结核病抗生素先导物。自上世纪90年代以来，美国疾病控制与预防中心（Centers for Disease Control and Prevention，简称cdc）在越南的临床实验室和艾滋病毒/艾滋病/结核病监测系统上投入了大量资金，尽管这些和其他一些努力主要集中在建设医疗基础设施上。我们的建议将通过加强基础和转化科学研究基础设施以及一个研究人员培训计划来弥补这一差距，该计划侧重于利用东道国资源发现治疗结核病的抗生素线索，并通过河内协调的抗生素线索筛查计划探索其基本致病性机制。这个项目的成功是由短期和长期的研究培训和教育驱动的。UIC与VAST有着良好的合作记录。在过去的20年里，通过美国国立卫生研究院和麦克阿瑟基金会的资助，该团队致力于建立一个基于植物的药物先导发现和资源保护计划。然而，越南拥有超过3000公里的海岸线，拥有世界上最丰富的海洋生物多样性，该提案旨在从中挖掘。1)通过在UIC长期培养博士后，在IMBC-VAST/NIHE建立3名独立研究员；2)在项目期间对9名IMBC/NIHE博士预科生进行短期和长期抗生素特异性培训；3)通过在NIHE建立体外结核分枝杆菌筛查项目，加强生物检测研究基础设施。在五年的时间里，我们的项目将培养12名训练有素的科学家，专门从事结核病抗生素的发现和开发。在各自研究所所长和院长的大力支持下，12名科学家中的3名将建立独立的研究小组，以补充一个更广泛的项目，该项目利用越南的自然资源发现结核病抗生素，并利用这些线索探索结核分枝杆菌致病性机制。在五年项目期间之后，IMBC和NIHE研究能力的显著提高将使越南北部成为结核病转化筛查中心，并将促进与越南国内外机构的合作。

项目成果

Cytotoxic Phenolic Compounds from Fruit Glandular Trichomes of Macaranga tanarius.

来自 Macaranga tanarius 果实腺毛的细胞毒性酚类化合物。

• DOI: 10.1155/2019/2917032
• 发表时间: 2019
• 期刊: Journal of analytical methods in chemistry
• 影响因子: 2.6
• 作者: Doan,ThiMaiHuong;Nguyen,ThuyLinh;Trinh,ThiThanhVan;Vu,VanNam;Phi,ThiDao;Litaudon,Marc;Roussi,Fanny;Chau,VanMinh;Pham,VanCuong
• 通讯作者: Pham,VanCuong

Dihydrostilbene glycosides from Camellia sasanqua and their α-glucosidase and α-amylase inhibitory activities.

茶梅中的二氢二苯乙烯苷及其α-葡萄糖苷酶和α-淀粉酶抑制活性。

• DOI: 10.1080/14786419.2020.1756802
• 发表时间: 2021
• 期刊: Natural product research
• 影响因子: 2.2
• 作者: Cuc,NguyenThi;Cuong,NguyenThe;Anh,LuuThe;Yen,DuongThiHai;Tai,BuiHuu;ThuTrang,Duong;Yen,PhamHai;Kiem,PhanVan;Nam,NguyenHoai;Minh,ChauVan;Nhiem,NguyenXuan
• 通讯作者: Nhiem,NguyenXuan

The need to innovate sample collection and library generation in microbial drug discovery: a focus on academia.

• DOI: 10.1039/d0np00029a
• 发表时间: 2021-03-04
• 期刊: Natural product reports
• 影响因子: 11.9
• 作者: Hernandez A;Nguyen LT;Dhakal R;Murphy BT
• 通讯作者: Murphy BT

Automated Microbial Library Generation Using the Bioinformatics Platform IDBac.

• DOI: 10.3390/molecules27072038
• 发表时间: 2022-03-22
• 期刊: Molecules (Basel, Switzerland)