Membrane-Acting Peptides
Membrane-Acting Peptides
批准号:
10114789
负责人:
JUN F LIANG
金额:
$46.26万
依托单位国家:
美国
项目类别:
财政年份:
2020
资助国家:
美国
项目状态:
已结题
起止时间:
2020-09-15 至 2024-08-31
关键词:
AffectAntifungal AgentsAntiviral AgentsApoptosisBindingBiologicalBiological AssayBiological ProcessCell CommunicationCell Culture TechniquesCell membraneCell surfaceCellsChargeCoculture TechniquesComputer SimulationConfocal MicroscopyCultured CellsCytolysisDevelopmentDiseaseEndocrineGrowth FactorHealthHumanIn VitroLeftLigandsMembraneMembrane PotentialsMethodsModernizationNamesNatural SelectionsNatureNeurotransmittersOrganismParacrine CommunicationPeptide Signal SequencesPeptidesPharmaceutical ChemistryPharmacologic SubstancePhysiological ProcessesProcessPropertyProteinsResearchScanning Electron MicroscopySeriesSignal TransductionSiteStainsStructureSurfaceTechnologyTestingTherapeuticadvanced analyticsantimicrobialbasecancer cellcell growthdesignexperimental studyimprovedinsightinterestlead optimizationmacromoleculeneglectnovel strategiesscreeningself assemblysmall moleculetool
中文摘要
膜作用多肽
生物活性多肽调节许多生理过程,在某些部位起到内分泌或旁分泌的作用。
信号和其他的神经递质或生长因子,对人类有重要和积极的影响
健康包括抗菌、抗真菌、抗病毒和抗肿瘤活动。在这个项目中,我们将探索
膜作用肽的一种新的基本设计方法。我们将:1)设计和开发新的生物活性
基于膜上多肽组装的多肽;2)体外研究多肽的生物学意义;3)
评价前景看好的多肽在疾病细胞和共培养中的药学意义。
英文摘要
Membrane-Acting Peptides
Bioactive peptides regulate many physiological processes, acting at some sites as endocrine or paracrine
signals and at others as neurotransmitters or growth factors, have important and positive impacts on human
health including antimicrobial, antifungal, antiviral, and antitumor activities. In this project, we will explore
a new rationale design approach to membrane-acting peptides. We will: 1) design and develop new bioactive
peptides based on on-membrane peptide assembly; 2) study the biological implications of peptides in vitro; 3)
evaluate the pharmaceutical significance of promising peptides on disease cells and co-cultures.
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会议论文
Engineered Intravascular Catheters for the Treatment of Bacteremia
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批准号:8676368
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财政年份:2014
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负责人:JUN F LIANG
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依托单位:
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批准号:8836488
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批准号:7580106
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依托单位:
Biofilm Growth on Functionalized Surfaces
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批准号:7843515
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财政年份:2009
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Intracellular Radiation as a Novel Approach for Infection Treatment
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批准号:7740532
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项目类别:
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资助金额:$19.13万
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财政年份:2009
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负责人:JUN F LIANG
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依托单位:
Intracellular Radiation as a Novel Approach for Infection Treatment
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批准号:7895524
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项目类别:
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资助金额:$21.63万
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财政年份:2009
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负责人:JUN F LIANG
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依托单位:
Membrane-Acting Lytic Peptides
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批准号:7318289
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项目类别:
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资助金额:$21.77万
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财政年份:2007
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负责人:JUN F LIANG
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Polymer Grafted Implant Surfaces with Biofilm Sensitizing Ability
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批准号:7318286
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项目类别:
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资助金额:$21.77万
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财政年份:2007
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负责人:JUN F LIANG
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依托单位:
海外基金