Membrane-Acting Peptides
Membrane-Acting Peptides
批准号:
10114789
负责人:
JUN F LIANG
金额:
$46.26万
依托单位国家:
美国
项目类别:
财政年份:
2020
资助国家:
美国
项目状态:
已结题
起止时间:
2020-09-15 至 2024-08-31
关键词:
AffectAntifungal AgentsAntiviral AgentsApoptosisBindingBiologicalBiological AssayBiological ProcessCell CommunicationCell Culture TechniquesCell membraneCell surfaceCellsChargeCoculture TechniquesComputer SimulationConfocal MicroscopyCultured CellsCytolysisDevelopmentDiseaseEndocrineGrowth FactorHealthHumanIn VitroLeftLigandsMembraneMembrane PotentialsMethodsModernizationNamesNatural SelectionsNatureNeurotransmittersOrganismParacrine CommunicationPeptide Signal SequencesPeptidesPharmaceutical ChemistryPharmacologic SubstancePhysiological ProcessesProcessPropertyProteinsResearchScanning Electron MicroscopySeriesSignal TransductionSiteStainsStructureSurfaceTechnologyTestingTherapeuticadvanced analyticsantimicrobialbasecancer cellcell growthdesignexperimental studyimprovedinsightinterestlead optimizationmacromoleculeneglectnovel strategiesscreeningself assemblysmall moleculetool
中文摘要
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英文摘要
Membrane-Acting Peptides
Bioactive peptides regulate many physiological processes, acting at some sites as endocrine or paracrine
signals and at others as neurotransmitters or growth factors, have important and positive impacts on human
health including antimicrobial, antifungal, antiviral, and antitumor activities. In this project, we will explore
a new rationale design approach to membrane-acting peptides. We will: 1) design and develop new bioactive
peptides based on on-membrane peptide assembly; 2) study the biological implications of peptides in vitro; 3)
evaluate the pharmaceutical significance of promising peptides on disease cells and co-cultures.
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会议论文
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财政年份:2014
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依托单位:
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批准号:7580106
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批准号:7740532
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资助金额:$19.13万
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财政年份:2009
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财政年份:2009
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财政年份:2007
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项目类别:
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资助金额:$21.77万
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财政年份:2007
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依托单位:
海外基金