Study epigenetic inheritance during development and across generations using multiple model organisms
使用多种模式生物研究发育过程中和跨代的表观遗传
基本信息
- 批准号:10119077
- 负责人:
- 金额:$ 0.86万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-05-01 至 2023-04-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAdultAnimal ModelAppearanceAwardBiologyCell divisionCellsChromatinComplexCongenital AbnormalityDNADNA SequenceDNA biosynthesisDefectDevelopmentDevelopmental BiologyDiabetes MellitusDiseaseEpigenetic ProcessEukaryotic CellFundingGene ExpressionGenerationsGenetic MaterialsGenomeHealthHistone H2AHistonesHomeostasisHumanInfertilityLeadMalignant NeoplasmsMuscular DystrophiesNeurodegenerative DisordersOrganismParentsPost-Translational Protein ProcessingProcessProteinsRegenerative MedicineStructureTimecell typedaughter cellepigenetic regulationepigenomegenetic informationhistone modificationhuman diseaseneoplastic cellstem cell biologyzygote
项目摘要
Abstract of the funded parent award R35 GM127075: The process of DNA replication allows the genetic
information of a cell to be copied and transferred reliably to its daughter cells through cell divisions. However, if DNA
replication and cell division were carried out in a symmetric manner, it would result in a cluster of tumor cells instead of
a multicellular organism. For example, an adult human being has more than 30 trillion cells comprised of more than 200
cell types. All these different cells with distinct appearances and functions originate from a single cell—a fertilized egg.
Therefore, a central question to understanding any multicellular organism is how cells become different while faithfully
maintaining the same genetic material.
Addressing this question also has far-reaching impact on human health. This is because even though most cells
in our bodies carry identical DNA sequences, only a subset of these sequences turn on expression at the proper time, in
the right place, and with the precise level during development and homeostasis. It is the distinct epigenetic information
contained in each cell type that defines its unique gene expression. In eukaryotic cells, an important epigenetic
regulation is through post-translational modifications of histones. Every ~147-bp double helix DNA wraps around an
octamer structure composed of histone H2A, H2B, H3, and H4 proteins, each in two copies. Incorporation of new
histones onto the DNA mainly occurs during DNA replication, which, in addition to copying the genome, requires
duplication of the epigenome. However, how the epigenetic information contained in the parental cell can be
maintained or changed in the daughter cells remains largely unknown. This question is extremely difficult to study
because the epigenome is composed of numerous components that dynamically change their composition. This question
is also extremely crucial for understanding the fundamental principles of biology and developing new treatments for
human diseases, since mis- regulation of epigenetic information could lead to developmental defects or diseases such as
infertility, birth defects, neurodegenerative disease, muscular dystrophy, diabetes, and many forms of cancer
摘要资助的父母奖R35 GM 127075:DNA复制的过程允许遗传
通过细胞分裂将细胞的信息可靠地复制和转移到其子细胞。如果DNA
如果复制和细胞分裂以对称的方式进行,则会产生肿瘤细胞簇,而不是
多细胞生物例如,一个成年人有超过30万亿个细胞,
细胞类型。所有这些具有不同外观和功能的不同细胞都起源于一个单一的细胞受精卵。
因此,理解任何多细胞生物的一个中心问题是,细胞如何在忠实地
保持相同的遗传物质。
解决这个问题对人类健康也有深远的影响。这是因为即使大多数细胞
在我们的身体携带相同的DNA序列,只有这些序列的一个子集在适当的时候打开表达,
正确的位置,并在发展和稳态的精确水平。它是不同的表观遗传信息
包含在每种细胞类型中,定义了其独特的基因表达。在真核细胞中,
调节是通过组蛋白的翻译后修饰。每一个~147-bp的双螺旋DNA都围绕着一个
由组蛋白H2 A、H2 B、H3和H4蛋白组成的八聚体结构,每个蛋白有两个拷贝。纳入新
组蛋白进入DNA主要发生在DNA复制过程中,除了复制基因组外,
表观基因组的复制然而,亲本细胞中所含的表观遗传信息如何能够
在子细胞中维持或改变的基因在很大程度上仍是未知的。这个问题极难研究
因为表观基因组是由许多动态改变其组成的成分组成的。这个问题
对于理解生物学的基本原理和开发新的治疗方法也是至关重要的。
人类疾病,因为表观遗传信息的错误调节可能导致发育缺陷或疾病,
不育症、出生缺陷、神经退行性疾病、肌肉萎缩症、糖尿病和多种形式的癌症
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
XIN CHEN其他文献
XIN CHEN的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('XIN CHEN', 18)}}的其他基金
Epigenetic Regulation of Germ Cell Differentiation from a Stem Cell Lineage
干细胞谱系生殖细胞分化的表观遗传调控
- 批准号:
10612791 - 财政年份:2020
- 资助金额:
$ 0.86万 - 项目类别:
Epigenetic Regulation of Germ Cell Differentiation from a Stem Cell Lineage
干细胞谱系生殖细胞分化的表观遗传调控
- 批准号:
10213795 - 财政年份:2020
- 资助金额:
$ 0.86万 - 项目类别:
Epigenetic Regulation of Germ Cell Differentiation from a Stem Cell Lineage
干细胞谱系生殖细胞分化的表观遗传调控
- 批准号:
10373066 - 财政年份:2020
- 资助金额:
$ 0.86万 - 项目类别:
Epigenetic Regulation of Germ Cell Differentiation from a Stem Cell Lineage
干细胞谱系生殖细胞分化的表观遗传调控
- 批准号:
10033955 - 财政年份:2020
- 资助金额:
$ 0.86万 - 项目类别:
Study epigenetic inheritance during development and across generations using multiple model
使用多种模型研究发育过程中和跨代的表观遗传
- 批准号:
9922325 - 财政年份:2018
- 资助金额:
$ 0.86万 - 项目类别:
Study epigenetic inheritance during development and across generations using multiple model
使用多种模型研究发育过程中和跨代的表观遗传
- 批准号:
10608924 - 财政年份:2018
- 资助金额:
$ 0.86万 - 项目类别:
Study epigenetic inheritance during development and across generations using multiple model
使用多种模型研究发育过程中和跨代的表观遗传
- 批准号:
10159295 - 财政年份:2018
- 资助金额:
$ 0.86万 - 项目类别:
Study epigenetic inheritance during development and across generations using multiple model
使用多种模型研究发育过程中和跨代的表观遗传
- 批准号:
10400162 - 财政年份:2018
- 资助金额:
$ 0.86万 - 项目类别:
Study epigenetic inheritance during development and across generations using multiple model
使用多种模型研究发育过程中和跨代的表观遗传
- 批准号:
9693395 - 财政年份:2018
- 资助金额:
$ 0.86万 - 项目类别:
Study the generality of asymmetric histone inheritance
研究不对称组蛋白遗传的普遍性
- 批准号:
8953592 - 财政年份:2015
- 资助金额:
$ 0.86万 - 项目类别:
相似海外基金
Co-designing a lifestyle, stop-vaping intervention for ex-smoking, adult vapers (CLOVER study)
为戒烟的成年电子烟使用者共同设计生活方式、戒烟干预措施(CLOVER 研究)
- 批准号:
MR/Z503605/1 - 财政年份:2024
- 资助金额:
$ 0.86万 - 项目类别:
Research Grant
Early Life Antecedents Predicting Adult Daily Affective Reactivity to Stress
早期生活经历预测成人对压力的日常情感反应
- 批准号:
2336167 - 财政年份:2024
- 资助金额:
$ 0.86万 - 项目类别:
Standard Grant
RAPID: Affective Mechanisms of Adjustment in Diverse Emerging Adult Student Communities Before, During, and Beyond the COVID-19 Pandemic
RAPID:COVID-19 大流行之前、期间和之后不同新兴成人学生社区的情感调整机制
- 批准号:
2402691 - 财政年份:2024
- 资助金额:
$ 0.86万 - 项目类别:
Standard Grant
Migrant Youth and the Sociolegal Construction of Child and Adult Categories
流动青年与儿童和成人类别的社会法律建构
- 批准号:
2341428 - 财政年份:2024
- 资助金额:
$ 0.86万 - 项目类别:
Standard Grant
Elucidation of Adult Newt Cells Regulating the ZRS enhancer during Limb Regeneration
阐明成体蝾螈细胞在肢体再生过程中调节 ZRS 增强子
- 批准号:
24K12150 - 财政年份:2024
- 资助金额:
$ 0.86万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Understanding how platelets mediate new neuron formation in the adult brain
了解血小板如何介导成人大脑中新神经元的形成
- 批准号:
DE240100561 - 财政年份:2024
- 资助金额:
$ 0.86万 - 项目类别:
Discovery Early Career Researcher Award
Laboratory testing and development of a new adult ankle splint
新型成人踝关节夹板的实验室测试和开发
- 批准号:
10065645 - 财政年份:2023
- 资助金额:
$ 0.86万 - 项目类别:
Collaborative R&D
Usefulness of a question prompt sheet for onco-fertility in adolescent and young adult patients under 25 years old.
问题提示表对于 25 岁以下青少年和年轻成年患者的肿瘤生育力的有用性。
- 批准号:
23K09542 - 财政年份:2023
- 资助金额:
$ 0.86万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Identification of new specific molecules associated with right ventricular dysfunction in adult patients with congenital heart disease
鉴定与成年先天性心脏病患者右心室功能障碍相关的新特异性分子
- 批准号:
23K07552 - 财政年份:2023
- 资助金额:
$ 0.86万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Issue identifications and model developments in transitional care for patients with adult congenital heart disease.
成人先天性心脏病患者过渡护理的问题识别和模型开发。
- 批准号:
23K07559 - 财政年份:2023
- 资助金额:
$ 0.86万 - 项目类别:
Grant-in-Aid for Scientific Research (C)