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Toward an accuracy-efficiency balanced model for modeling high intensity focused ultrasound

建立用于模拟高强度聚焦超声的精度-效率平衡模型

基本信息

批准号：
10115992
负责人：
Yun Jing
金额：
$ 31.91万
依托单位：
PENNSYLVANIA STATE UNIVERSITY, THE
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-02-01 至 2021-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10115992
关键词：
3-Dimensional Acoustics Address Adopted Algorithms Benchmarking Biological Coagulation Process Code Communities Complex Computer software Consumption Device Designs Devices Disease Documentation Elements Engineering Equation Equilibrium Face Focused Ultrasound Therapy Fractionation Frequencies Heterogeneity Human Investigation Linear Models Manuals Measurement Mechanics Medical Methodology Methods Modality Modeling Names Operative Surgical Procedures Phase Physiologic pulse Protocols documentation Research Research Personnel Shock Software Engineering Sonication System Techniques Technology Temperature Testing Therapeutic Time Tissues Transducers Ultrasonic Transducer Ultrasonography Work X-Ray Tomography base clinical translation cranium design experimental study flexibility improved novel open source predictive modeling pressure simulation software development treatment planning vector web site

项目摘要

Abstract High intensity focused ultrasound (HIFU) has been heavily investigated over the past two decades for treating a wide range of diseases and medical conditions. As a non-invasive surgical modality that can reach deep tissues, HIFU has the potential to revolutionize therapy. A versatile and fast yet sufficiently accurate ultrasound numerical model is vital for HIFU. Such a numerical model could serve as a powerful platform for in-depth investigation of HIFU and as a springboard for clinical translation of HIFU techniques. Some specific applications include testing new sonication protocols, understanding the mechanism of certain HIFU techniques, and rapid treatment planning. Two common HIFU techniques exist: they are the thermal based HIFU technique and shock wave based HIFU technique. While the first type uses relatively low pressure continuous wave (CW) and primarily causes thermal coagulation, the second type uses high pressure shock wave pulses to cause mechanical fractionation of tissue. To this date, no model can efficiently and accurately model these two types of HIFU in three-dimensional (3D) large-scale, complex, heterogeneous biological tissue. In the proposed research, we shall address a longstanding need in the HIFU community for a novel, accuracy- efficiency balanced numerical model. In Aim 1, we shall create a versatile, accuracy-efficiency balanced algorithm for HIFU modeling. By considering tissue heterogeneities in the Westervelt equation, a modified wave- vector-frequency-domain (M-WVFD) method for predicting linear/nonlinear wave fields in arbitrarily heterogeneous media will be systematically investigated for the first time. The resulting model is expected to be at least two orders of magnitude faster than the state-of-the-art “accurate” models and still have high accuracy. In Aim 2, the M-WVFD method will be numerically and experimentally validated by investigating a variety of HIFU problems. The experiments will involve both phantom and ex-vivo human skulls in order to investigate wave propagation in weakly and strongly heterogeneous media. Aim 3 shall focus on software engineering, so that the developed algorithms can be integrated into an open-source software package and can be widely adopted by the HIFU community.

摘要在过去的二十年里，高强度聚焦超声（HIFU）已经被大量研究用于治疗广泛的疾病和医疗条件。作为一种可以到达深层组织的非侵入性手术方式，高强度聚焦超声有可能彻底改变治疗方法。一个多功能和快速但足够准确的超声数值模型是HIFU的关键。这种数值模式可以作为一个强大的平台，深入调查作为HIFU技术临床转化的跳板。一些特定的应用包括测试新的超声处理方案，理解某些HIFU技术的机制，以及快速治疗规划存在两种常见的HIFU技术：基于热的HIFU技术和基于冲击波的HIFU技术法而第一种类型使用相对低压的连续波（CW），并且主要引起热第二种类型使用高压冲击波脉冲来引起组织的机械分离。到目前为止，没有模型可以在三维（3D）中有效和准确地对这两种类型的HIFU进行建模。大规模、复杂、异质的生物组织。在拟议的研究中，我们将解决HIFU社区长期以来对一种新颖、准确的效率平衡数值模型在目标1中，我们将创建一个通用的，准确性和效率平衡的算法进行HIFU建模。通过考虑Westerpyruvate方程中的组织不均匀性，提出了一种修正的波- 矢量频域（M-WVFD）方法预测线性/非线性波场，将首次对非均匀介质进行系统研究。由此产生的模型预计将是比现有技术的“精确”模型快至少两个数量级，并且仍然具有高精度。在目标2中，将通过研究各种HIFU来数值和实验验证M-WVFD方法问题实验将涉及体模和离体人类头骨，以研究波在弱和强非均匀介质中的传播。目标3应侧重于软件工程，开发的算法可以集成到一个开源软件包中，并可以被广泛采用， HIFU社区