Chronic Pain Severity, Biomarkers of Dementia, and Ethnic/Race Group Differences: Predicting Alzheimer's Disease Vulnerabilities

项目总结/摘要 非西班牙裔黑人（NHB）美国人患阿尔茨海默病的风险大大增加， 非西班牙裔白色美国人。与健康有关的脆弱性与生物心理社会压力有关， 这不成比例地影响了NHB人群。生活在慢性疼痛中是有压力的。骨关节炎（OA）是一种 高度流行且使人衰弱的慢性疼痛状况，对NHB成人的影响比NHW更严重 成年人了慢性疼痛与全身炎症升高和痴呆风险增加有关， 这对NHB美国人的影响不成比例。此外，NHB美国人也有升高的遗传和 痴呆症的生物标志物，但这些生物标志物和痴呆症之间的关系较弱， NHB比NHW人口。有证据表明，NHB成年人的淀粉样蛋白阳性大脑似乎比正常人年龄大。 预期这可能是由于种族/种族群体在环境、社会文化和健康方面的差异造成的。 相关的压力暴露。整个生命周期的累积暴露可能会降低大脑储备， 通过对生物系统造成损害来降低痴呆症的脆弱性。这表明生活经验因素， 包括慢性疼痛，可能在神经变性过程中起作用。因此，族裔/种族， 考虑社会人口统计学和心理社会因素，结合疼痛严重程度， 阿尔茨海默病的关键弱点。目前尚不清楚的是：1）NHB和NHW与慢性膝关节炎 疼痛在炎症和痴呆的生物标志物上不同，如果2）疼痛严重程度高的NHB相对 与NHW同龄人相比，这些生物标志物和全球认知随着时间的推移发生了更大的变化。我们将使用 来自现有R 01的数据，以处理炎症的血浆生物标志物和新型脑MRI生物标志物， 痴呆我们有120名成年人的全面的生物心理社会，MRI和一般认知数据， 2年期间慢性疼痛的证据（60 NHB，60 NHW）。我们的研究结果将1）有助于 提高对慢性疼痛、种族/人种和痴呆风险之间动态关系的理解; 2） 促进识别对压力相关暴露敏感的新型脑MRI生物标志物， 痴呆风险

Project Summary/Abstract Non-Hispanic black (NHB) Americans experience greatly increased risk of Alzheimer’s disease compared to non-Hispanic white (NHW) Americans. Health-related vulnerabilities are linked with biopsychosocial stress, which disproportionately affects NHB populations. Living with chronic pain is stressful. Osteoarthritis (OA) is a highly prevalent and debilitating chronic pain condition that affects NHB adults more severely than NHW adults. Chronic pain is associated with elevated systemic inflammation and increased risk of dementia, both of which disproportionately affect NHB Americans. Additionally, NHB Americans also have elevated genetic and biological markers of dementia but there are weaker relationships between those biomarkers and dementia in NHB than NHW populations. Evidence suggests the amyloid-positive brains of NHB adults appear older than expected. This might be due to ethnic/race groups differences in environmental, sociocultural, and health- related stress exposures. Cumulative exposure across the lifespan might reduce brain reserve and induce vulnerabilities to dementia by taking a toll on the biological system. This suggests life experience factors, including chronic pain, might play a role in neurodegenerative processes. Therefore, ethnicity/race, with consideration for sociodemographic and psychosocial factors, combined with pain severity might serve as a key vulnerability for Alzheimer’s disease. What is not known is whether: 1) NHB and NHW with chronic knee pain differ in biomarkers of inflammation and dementia, and if 2) NHB with high pain severity have relatively greater changes in those biomarkers and global cognition over time compared to their NHW peers. We will use data from an existing R01 to process plasma biomarkers and novel brain MRI biomarkers of inflammation and dementia. We have comprehensive biopsychosocial, MRI, and general cognitive data for 120 adults with evidence of chronic pain (60 NHB, 60 NHW) across a two-year period. Our findings will 1) contribute to an improved understanding of the dynamics between chronic pain, ethnicity/race, and dementia risk; and 2) promote the identification of novel brain MRI biological markers sensitive to stress-related exposure and dementia risk.