Associations of Neighborhood Green Space and Social Disadvantage with Stress-Sensitive Inflammatory Biomarkers

邻里绿地和社会劣势与压力敏感炎症生物标志物的关联

• 批准号: 10083225
• 负责人: Laken Camille Roberts
• 金额: $ 4.6万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-01 至 2021-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10083225
• 关键词: Acute-Phase Proteins; Address; Adult; Affect; African American; Age; Area; Attenuated; Baltimore; Biological; Biological Markers; Blood Pressure; C-reactive protein; Cardiovascular Diseases; Cardiovascular system; Cell Adhesion Molecules; Characteristics; Cities; Cohort Studies; Communities; Crime; Cross-Sectional Studies; Data; Data Analyses; Data Reporting; Disease; Economics; Elderly; Environment; Environmental Exposure; Exposure to; Female; Foundations; Functional disorder; Geology; Government Agencies; Green space; Health; Health Benefit; Heart; Hospitalization; Hydrocortisone; Hypothalamic structure; Impaired cognition; Individual; Inflammatory; Institution; Intercellular adhesion molecule 1; Interleukin-1 beta; Interleukin-6; Intervention; Lead; Link; Maps; Measures; Medical; Memory; National Heart, Lung, and Blood Institute; Neighborhoods; Obesity; Outcome; Participant; Patient Self-Report; Physical activity; Physiological; Pituitary Gland; Population; Prevention strategy; Productivity; Public Health; Relaxation; Research; Resources; Risk Factors; Risk Reduction; Role; Safety; Salivary; Sampling; Serum; Services; Social Conditions; Social Disorganizations; Social Interaction; Stress; TNF gene; Testing; Training; United States; Urban Community; Urban Developments; Vascular Cell Adhesion Molecule-1; aged; allostatic load; biological adaptation to stress; biological systems; cardiovascular disorder risk; cardiovascular health; cardiovascular risk factor; community intervention; cost; cytokine; density; deprivation; disease disparity; experience; hazard; health difference; healthy lifestyle; human old age (65+); indexing; land cover; middle age; mortality; neighborhood association; physical inactivity; policy implication; programs; psychosocial; residence; resilience; response; skills; social; social capital; social determinants; social disadvantage; social health determinants; social stress; theories; therapy development; urban dwelling; urban planning

PROJECT SUMMARY/ABSTRACT Cardiovascular disease (CVD) is a major public health concern that affected 41% of the United States population and cost $555 billion in medical spending and lost productivity in 2016. Prevention strategies that intervene on social determinants of health, such as neighborhood environmental characteristics, are one approach to decreasing the growing burden of CVD. Neighborhood green spaces, including parks, recreational areas, and vegetation, are modifiable and important neighborhood factors have been associated with lower CVD risk and better physiologic outcomes. Green spaces may protect against CVD by mitigating stress through physical activity, relaxation, and positive social interactions that reduce individuals’ exposure to stressful social conditions. Neighborhood social disadvantage, measured as neighborhood psychosocial hazards comprised of social disorganization, safety, physical disorder, and economic deprivation, likely provokes a stress response that may lead to hypothalamic–pituitary–adrenocortical (HPA) axis dysfunction with regular exposure. Psychosocial hazards have been associated with increased CVD risk and higher levels of stress sensitive pro-inflammatory biomarkers. The health benefits of neighborhood green space suggest it may serve as a potential resilience factor against neighborhood social disadvantage. The proposed cross-sectional study will examine associations among neighborhood green space, neighborhood social disadvantage, and stress sensitive pro-inflammatory biomarkers in a sample of 624 urban-dwelling, middle-aged and older adults. This study is a secondary data analysis of the Baltimore Memory Study, a cohort study that investigated determinants of cognitive decline in 1,140 Baltimore City residents ages 50 to 70-year-old from 65 contiguous city neighborhoods (R01 AG19604, PI: B. Schwartz). Study data will be paired with satellite maps of vegetated land cover from the United States Geological Service to measure green space. The specific aims of the proposed study are to test: (1) the association between neighborhood green space and stress sensitive pro-inflammatory biomarkers; (2) the association between neighborhood social disadvantage and stress sensitive pro-inflammatory biomarkers; and (3) whether neighborhood green space modifies the association between neighborhood social disadvantage and stress sensitive pro-inflammatory biomarkers. These findings may help clarify the role of neighborhood green spaces as a modifiable neighborhood resilience factor that can be targeted for community-level interventions to reduce CVD risk. This proposed study aligns with the National Heart, Lung, and Blood Institute’s priorities to investigate factors that account for differences in health among populations and to understand how environmental exposures and social determinants modulate biological systems and promote resilience. The proposed training plan is foundational to a program of research focused on understanding social and environmental contributors to cardiovascular health and developing skills to create targeted interventions that promote heart-healthy lifestyles.

项目总结/摘要 心血管疾病（CVD）是一个主要的公共卫生问题，影响了41%的美国人口 2016年，医疗支出和生产力损失高达5550亿美元。预防战略， 健康的社会决定因素，如邻里环境特征，是一种方法， 降低CVD的负担。邻里绿色空间，包括公园、娱乐区和 植被是可改变的，重要的邻里因素与较低的CVD风险有关， 更好的生理结果。绿色空间可以通过物理作用减轻压力来防止CVD 活动、放松和积极的社会互动，减少个人暴露在有压力的社会条件下。 邻里社会劣势，衡量为邻里社会心理危害，包括社会 无组织、安全、身体障碍和经济贫困，可能会引起压力反应， 导致下丘脑-垂体-肾上腺皮质（HPA）轴功能障碍。心理社会 危险与心血管疾病风险增加和应激敏感性促炎因子水平升高有关。 生物标志物。邻里绿色空间的健康益处表明，它可能成为一种潜在的恢复力 邻里社会不利因素。拟议的横断面研究将审查协会 邻里绿色空间、邻里社会劣势、应激敏感性促炎因子之间的关系 624名城市居民、中年人和老年人样本中的生物标志物。本研究为二手资料 对巴尔的摩记忆研究的分析，这是一项队列研究，调查了认知能力下降的决定因素， 来自65个相邻城市社区的1,140名巴尔的摩市50至70岁的居民（R 01 AG 19604， PI：B. Schwartz）。研究数据将与美国植被覆盖的卫星地图配对 地质服务测量绿色空间。拟议研究的具体目的是测试：（1） 邻近绿色空间和应激敏感性促炎生物标志物之间的关联;（2） 邻里社会劣势与应激敏感性促炎生物标志物之间的关联;以及 (3)邻里绿色空间是否改变了邻里社会劣势与 应激敏感性促炎生物标志物。这些发现可能有助于澄清邻里绿色的作用 空间作为一个可修改的邻里弹性因素，可以针对社区一级的干预措施， 降低CVD风险。这项拟议的研究符合国家心脏，肺和血液研究所的优先事项， 调查解释人群健康差异的因素，并了解 环境风险和社会决定因素调节生物系统并促进复原力。的 拟议的培训计划是一个研究计划的基础，重点是了解社会和 环境因素对心血管健康的影响，并发展技能，以制定有针对性的干预措施， 促进心脏健康的生活方式。