Improving Spatiotemporal Precision in Noninvasive Electrical Neuromodulation

提高无创电神经调节的时空精度

• 批准号: 10082466
• 负责人: Don M Tucker
• 金额: $ 82.43万
• 依托单位: BRAIN ELECTROPHYSIOLOGY LABORATORY COMPANY, LLC
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-23 至 2021-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10082466
• 关键词: Address; Agreement; Algorithms; Anterior; BRAIN initiative; Brain; Brain region; Clinical Trials; Computer Models; Computer Simulation; Discrimination; Electricity; Electrodes; Electroencephalography; Electronics; Elements; Esthesia; Fingers; Generations; Goals; Head; High Performance Computing; Human; Individual; Intervention; Length; Lidocaine; Linux; Location; Long-Term Depression; Measurement; Measures; Medical Device; Mental disorders; Methods; Modeling; Monitor; Motor; Motor Cortex; Motor Evoked Potentials; Muscle; Parahippocampal Gyrus; Pattern; Penetration; Periodicity; Phase; Physics; Physiologic pulse; Placebo Control; Placebos; Recovery; Regulation; Research; Research Project Grants; Resolution; Sales; Scientist; Shoulder; Site; Skin; Sleep; Slow-Wave Sleep; Small Business Innovation Research Grant; Source; Stimulus; Surface; System; Techniques; Technology; Testing; Time; Tissues; Utah; Validation; Variant; brain abnormalities; clinical practice; commercialization; cranium; design; digital; efficacy testing; electric field; electrical impedance tomography; experimental study; flexibility; frontal lobe; improved; meetings; neuroregulation; novel; operation; prevent; programs; response; sensor; signal processing; simulation; source localization; spatiotemporal; tool; validation studies; vector

This application describes the commercialization of the Geodesic Transcranial Electrical Neuromodulation (GTEN) technology to achieve noninvasive neuromodulation with improved spatiotemporal precision. The GTEN system enables both EEG source analysis and configurable electrical neuromodulation with the 256 electrodes of the Geodesic Sensor Net. Now in beta release to selected research customers, the GTEN technology will be fully commercialized as a medical device through addressing four specific aims guided by the goals for noninvasive neuromodulation in the BRAIN Initiative. (1) We will improve focal current delivery at deep as well as superficial brain locations with a novel targeting algorithm (Discriminative Cortical Source Vectoring) implemented with a high resolution conductivity model of the human head. (2) Both simulation and experiment will be used to minimize extraneous stimulation to non target regions while quantifying current delivered to all brain regions. (3) We will design and test a placebo mode to allow definitive clinical trials. (4) Closed loop operation will be achieved by guiding the localization and phase of GTEN intervention with simultaneous monitoring of source-localized EEG. In the validation of closed-loop operation, the EEG rhythms will be those of slow wave sleep, and they will be hypothesized to be enhanced in both depth and length during the night's sleep. Completing the aims of this SBIR will create a dEEG-guided noninvasive dense array electrical neuromodulation technology as a powerful, precise, and inexpensive technology for both research and clinical practice.

本申请描述了Geodesic经颅电神经调节的商业化 （GTEN）技术以实现具有改进的时空精度的非侵入性神经调节。的 GTEN系统可实现EEG源分析和可配置的电神经调节， Geodesic Sensor Net的电极。现在，GTEN正在向选定的研究客户发布测试版， 该技术将作为一种医疗器械完全商业化，通过解决以下四个具体目标： 非侵入性神经调节的目标。(1)我们将改善聚焦电流的输送， 深层以及表层的大脑位置与一种新的定位算法（辨别皮层源 矢量化）使用人体头部的高分辨率电导率模型实现。(2)仿真和 将使用实验来最小化对非目标区域的外来刺激，同时量化电流 传递到大脑的各个区域(3)我们将设计和测试安慰剂模式，以进行确定性的临床试验。（四） 闭环运行将通过指导GTEN干预的定位和阶段来实现， 同时监测源定位EEG。在闭环操作的验证中， 将是那些慢波睡眠，他们将被假设为在深度和长度上都得到增强， 晚上的睡眠。完成SBIR的目标将创建dEEG引导的非侵入性密集阵列 电神经调节技术作为一种强大、精确和廉价的技术， 和临床实践。

项目成果

Transcranial Electrical Stimulation targeting limbic cortex increases the duration of human deep sleep.

• DOI: 10.1016/j.sleep.2021.03.001
• 发表时间: 2021-05
• 期刊: Sleep medicine
• 影响因子: 4.8
• 作者: Hathaway E;Morgan K;Carson M;Shusterman R;Fernandez-Corazza M;Luu P;Tucker DM
• 通讯作者: Tucker DM

Focal limbic sources create the large slow oscillations of the EEG in human deep sleep.

• DOI: 10.1016/j.sleep.2021.07.028
• 发表时间: 2021-09
• 期刊: Sleep medicine
• 影响因子: 4.8
• 作者: Morgan KK;Hathaway E;Carson M;Fernandez-Corazza M;Shusterman R;Luu P;Tucker DM
• 通讯作者: Tucker DM

Source localization of epileptic spikes using Multiple Sparse Priors.

• DOI: 10.1016/j.clinph.2020.10.030
• 发表时间: 2021-03
• 期刊: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
• 作者: Fernandez-Corazza M;Feng R;Ma C;Hu J;Pan L;Luu P;Tucker D
• 通讯作者: Tucker D