Improving Spatiotemporal Precision in Noninvasive Electrical Neuromodulation

本申请描述了测地线经颅电神经调制的商业化 (GTEN)技术，以提高时空精度实现非侵入性神经调节。这个 GTEN系统支持脑电源分析和可配置的神经调制，256 测地线传感器网络的电极。现在，GTEN正在向选定的研究客户发布测试版 通过解决以下四个具体目标，技术将作为一种医疗设备完全商业化 大脑计划中非侵入性神经调节的目标。(1)我们将在以下方面改善焦点电流交付 使用一种新的目标定位算法(区分皮层来源)来定位大脑的深层和表层位置 矢量化)使用高分辨率的人头电导率模型来实现。(2)模拟和 实验将用于在量化电流的同时最大限度地减少对非靶区的外来刺激 传送到所有的大脑区域。(3)我们将设计和测试安慰剂模式，以进行最终的临床试验。(4) 将通过以下方式指导GTEN干预的本地化和阶段，从而实现闭环运行 同时监测病源定位的脑电。在验证闭环系统运行时，脑电节律 将是那些慢波睡眠，并假设它们在深度和长度上都会在 彻夜的睡眠。完成此SBIR的目标将创建DEEG引导的非侵入性高密度阵列 电神经调节技术作为一种强大、精确和廉价的技术用于这两项研究 和临床实践。

This application describes the commercialization of the Geodesic Transcranial Electrical Neuromodulation (GTEN) technology to achieve noninvasive neuromodulation with improved spatiotemporal precision. The GTEN system enables both EEG source analysis and configurable electrical neuromodulation with the 256 electrodes of the Geodesic Sensor Net. Now in beta release to selected research customers, the GTEN technology will be fully commercialized as a medical device through addressing four specific aims guided by the goals for noninvasive neuromodulation in the BRAIN Initiative. (1) We will improve focal current delivery at deep as well as superficial brain locations with a novel targeting algorithm (Discriminative Cortical Source Vectoring) implemented with a high resolution conductivity model of the human head. (2) Both simulation and experiment will be used to minimize extraneous stimulation to non target regions while quantifying current delivered to all brain regions. (3) We will design and test a placebo mode to allow definitive clinical trials. (4) Closed loop operation will be achieved by guiding the localization and phase of GTEN intervention with simultaneous monitoring of source-localized EEG. In the validation of closed-loop operation, the EEG rhythms will be those of slow wave sleep, and they will be hypothesized to be enhanced in both depth and length during the night's sleep. Completing the aims of this SBIR will create a dEEG-guided noninvasive dense array electrical neuromodulation technology as a powerful, precise, and inexpensive technology for both research and clinical practice.