Borrelia miyamotoi meningioencephalitis

宫本疏螺旋体脑膜脑炎

• 批准号: 10078262
• 负责人: Catherine Ayn Brissette
• 金额: $ 21.15万
• 依托单位: UNIVERSITY OF NORTH DAKOTA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10078262
• 关键词: Acute; Address; Age; Argasidae; Arthralgia; Autoimmune Diseases; B-Cell Antigen Receptor; B-Lymphocytes; Bacteria; Bacterial Infections; Biological Response Modifiers; Borrelia; Borrelia burgdorferi; Borrelia miyamotoi; Brain; Case Study; Cells; Central Nervous System Infections; Complex; Data; Disease; Dura Mater; Exposure to; Fever; Goals; Health Personnel; Hospitalization; Human; Imaging technology; Immune response; Immunity; Immunocompromised Host; Individual; Infection; Infection Control; Ixodes; Ixodidae; Japan; Kinetics; Laboratories; Location; Lyme Disease; Lymphocyte; Lymphoma; MS4A1 gene; Meningeal; Meninges; Meningitis; Meningoencephalitis; Mission; Monoclonal Antibodies; Mus; Myalgia; National Institute of Allergy and Infectious Disease; Nature; Neuraxis; Neurologic; Neutropenia; Order Spirochaetales; Ornithodoros; Pathogenesis; Pathogenicity; Pathology; Patients; Pattern; Physiological; Population; Positioning Attribute; Prevalence; Prevention strategy; Procedures; Public Health; Relapsing Fever; Reporting; Research; Risk; Role; Route; Russia; Seroprevalences; Serum; Site; Symptoms; Techniques; Testing; Thrombocytopenia; Tick-Borne Diseases; Ticks; Variant; Wild Type Mouse; alternative treatment; chemotherapy; climate change; congenic; experimental study; exposed human population; human pathogen; immunosuppressed; lymph nodes; mutant; neuropathology; pathogen; relapsing fever borrelia; response; rituximab; tick-borne; trafficking; vector tick

The meninges are important mediators of immune cell trafficking in response to infection in the central nervous system (CNS). A recently identified tick-borne human pathogen, Borrelia miyamotoi, causes an acute febrile illness, and may have serious complications in immunocompromised patients. Specifically, these patients are deficient in B cells and develop meningoencephalitis upon infection with B. miyamotoi. Our long-term goal is to determine the physiological mechanisms that underlie the neuropathologies associated with severe Borrelia miyamotoi disease (BMD). Our central hypothesis is that B. miyamotoi colonization of the meninges routinely occurs only in the absence of B cells. We will address this hypothesis with 2 Specific Aims: 1) Determining the kinetics of B. miyamotoi dissemination into the meninges in the absence of B cells; and, 2) Identifying immune responses that contribute to pathogen control. In Aim 1 of this proposal we will determine a) the kinetics of meningeal infection; b) the effects of inoculation site variation; and c) the spatial and temporal colonization patterns of meningeal infection. In Aim 2, we will determine the role of T-dependent B cell responses; and changes in brain microglial activation in response to B. miyamotoi infection. Completion of these aims will define the kinetics of B. miyamotoi colonization of the meninges and will determine if B cell responses are indeed required for control of infection. Overall, this proposal is relevant to the mission of NIAID because a greater understanding of severe BMD will enable healthcare providers to target at-risk patients with information about alternative treatments for their conditions and preventative strategies to avoid BMD and other tick-borne diseases.

脑膜是中枢神经感染反应中免疫细胞运输的重要介质

项目成果

Borrelia miyamotoi: A Comprehensive Review.

• DOI: 10.3390/pathogens12020267
• 发表时间: 2023-02-07
• 期刊: Pathogens (Basel, Switzerland)