PRIDE Academy: Impact of Ancestry and Gender to omics of lung diseases

项目摘要 这是“PRIDE Academy：祖先和性别对肺组学的影响”的新应用程序 疾病”，其目的是向代表性不足背景的学者介绍肺部组学 疾病，重点是在与代表性不足的人合作时应如何解释和应用数据集 人口。该学院将设在肺和生物医学信息学和个性化 科罗拉多州安舒茨医学园区的医学 (BiPM) 部门。肺科有一个 肺医学领导者培训和相对较新的 BiPM 部门的杰出历史记录 有助于阐明遗传学在多大程度上可以解释复杂疾病中的健康差异， 特别是哮喘。我们提议设立一个 PRIDE 夏季学院，其中包括教学和实践研讨会 肺部疾病（例如哮喘、肺气肿、肺纤维化和肺结核）的基因组学和蛋白质组学研究 高血压。 PRIDE 学者将被分配一个与受训者的研究密切相关的指导团队 兴趣。在这里，除了通常的教学和实践活动之外，我们还提出了额外的水平 使用学术“教练”概念的培训。教练并不是要取代导师，而是要取代导师 补充这种关系，因为教练不是与学者一对一地互动，而是作为一个群体进行互动。 教练将指导团队成员使用以下方法成功地驾驭学术界： 经过充分检验的社会科学方法。总体目标是选择有才华的、代表性不足的初级人员 对肺部疾病表现出兴趣的教职学者；向学者们介绍一个工具包，包括 指导团队、心肺疾病“组学”指导和一套社会科学理论 学业上的坚持；教练与学者配对，确保实现所有里程碑；提供 学者们拥有资助写作研讨会和模拟学习部分，这将使他们能够竞争校内的课程 和校外补助金；实施评估计划来衡量计划的实现程度 它的目标。学者们将连续两年前往丹佛参加 PRIDE 夏季学院，并 阿斯彭参加汤姆·佩蒂·阿斯彭年度肺病会议的年中面对面会议。通过使用 教练与社会科学实践的结合，例如文化资本和实践社区 让团队成员感受到彼此之间的联系，并将具有杰出肺功能的学者配对 和 BiPM 教师导师，我们将确保他们的学术坚持和最终成功。

PROJECT ABSTRACT This is a new application for a “PRIDE Academy: Impact of Ancestry and Gender on omics of lung diseases” whose objective is to introduce scholars from under-represented backgrounds to omics of lung diseases with a focus on how datasets should be interpreted and applied when working with under-represented populations. This academy will be housed at the Pulmonary and Biomedical Informatics and Personalized Medicine (BiPM) Divisions at Anschutz Medical Campus in Colorado. The Pulmonary Division has a distinguished historical record of training leaders in pulmonary medicine and the relatively new BiPM Division has been instrumental in elucidating to what extent genetics can explain health disparities in complex diseases, particularly asthma. We propose a PRIDE summer academy that will include didactic and hands-on workshops in genomics and proteomics of lung diseases such as asthma, emphysema, pulmonary fibrosis, and pulmonary hypertension. The PRIDE scholars will be assigned a mentoring team closely aligned with the mentees’ research interests. Here, in addition to the usual didactic and hands-on activities, we propose an additional level of training that uses the concept of academic “coaches”. A coach is not intended to supplant the mentor, but rather complement this relationship, since coaches do not interact with the scholars one-on-one but rather as a group. The coach will guide team members through the process of successfully navigating the academic world using well-tested social science approaches. The overall objectives are to select talented underrepresented junior faculty scholars with a demonstrated interest in pulmonary diseases; introduce the scholars to a toolkit including a mentoring team, instruction on “omics” of cardio-pulmonary diseases and a suite of social science theories for academic persistence; pair coaches with scholars to ensure that all the milestones are achieved; provide scholars with grant-writing workshops and mock study sections that will position them to compete for intramural and extramural grants; implement an evaluation plan that measures the degree to which the program is achieving its objectives. Scholars will travel to Denver for the PRIDE summer academies for 2 consecutive years and to Aspen for a face-to-face mid-year meeting at the Annual Tom Petty Aspen Lung Conference. By using the combination of coaching and social science practices such as cultural capital and communities of practice that allow team members to feel connected with each other, and pairing the scholars with distinguished pulmonary and BiPM faculty mentors, we will ensure their academic persistence and ultimate success.