PRIDE Academy: Impact of Ancestry and Gender to omics of lung diseases

项目摘要 这是“Pride Academy”的一个新应用：血统和性别对肺组学的影响 疾病》，其目的是介绍来自代表性不足背景的学者对肺组学的了解 疾病，重点是在处理代表性不足的情况下应如何解释和应用数据集 人口。该学院将设在肺和生物医学信息学和个性化 科罗拉多州安舒茨医学院的医学部。肺科有一个 肺部医学和相对较新的BIPM部门培训领导者的杰出历史记录 在阐明遗传学可以在多大程度上解释复杂疾病的健康差异方面起到了重要作用， 尤其是哮喘。我们建议开设一个骄傲的暑期班，包括授课和实践工作坊。 在肺部疾病的基因组学和蛋白质组学方面，如哮喘、肺气肿、肺纤维化和肺疾病 高血压。骄傲学者将被分配一个与被指导者的研究密切相关的指导团队 兴趣。在这里，除了通常的授课和动手活动外，我们还建议增加一个级别的 使用学术“教练员”概念的培训。教练并不是要取代导师，而是要取代导师 补充这种关系，因为教练不是一对一地与学者互动，而是作为一个小组进行互动。 教练将指导团队成员成功地在学术界使用 久经考验的社会科学方法。总体目标是选择有才华的、未被充分代表的青年 对肺部疾病表现出兴趣的学院学者；向学者介绍一个工具包，包括 一个指导团队，关于心肺疾病组学的指导和一套社会科学理论 学术坚持不懈；与学者结对指导，以确保实现所有里程碑；提供 设有助学金撰写研讨会和模拟研究小组的学者，将使他们处于竞争校内的地位 和校外赠款；实施评估计划，以衡量计划实现的程度 它的目标。奖学金获得者将连续两年前往丹佛参加骄傲夏季学院，并 阿斯彭在汤姆·佩蒂·阿斯彭肺脏年会上面对面的年中会议。通过使用 将指导和社会科学实践相结合，如文化资本和实践社区， 让团队成员感受到彼此的联系，并将学者与杰出的肺脏配对 和BIPM教师导师，我们将确保他们的学术坚持不懈和最终成功。

PROJECT ABSTRACT This is a new application for a “PRIDE Academy: Impact of Ancestry and Gender on omics of lung diseases” whose objective is to introduce scholars from under-represented backgrounds to omics of lung diseases with a focus on how datasets should be interpreted and applied when working with under-represented populations. This academy will be housed at the Pulmonary and Biomedical Informatics and Personalized Medicine (BiPM) Divisions at Anschutz Medical Campus in Colorado. The Pulmonary Division has a distinguished historical record of training leaders in pulmonary medicine and the relatively new BiPM Division has been instrumental in elucidating to what extent genetics can explain health disparities in complex diseases, particularly asthma. We propose a PRIDE summer academy that will include didactic and hands-on workshops in genomics and proteomics of lung diseases such as asthma, emphysema, pulmonary fibrosis, and pulmonary hypertension. The PRIDE scholars will be assigned a mentoring team closely aligned with the mentees’ research interests. Here, in addition to the usual didactic and hands-on activities, we propose an additional level of training that uses the concept of academic “coaches”. A coach is not intended to supplant the mentor, but rather complement this relationship, since coaches do not interact with the scholars one-on-one but rather as a group. The coach will guide team members through the process of successfully navigating the academic world using well-tested social science approaches. The overall objectives are to select talented underrepresented junior faculty scholars with a demonstrated interest in pulmonary diseases; introduce the scholars to a toolkit including a mentoring team, instruction on “omics” of cardio-pulmonary diseases and a suite of social science theories for academic persistence; pair coaches with scholars to ensure that all the milestones are achieved; provide scholars with grant-writing workshops and mock study sections that will position them to compete for intramural and extramural grants; implement an evaluation plan that measures the degree to which the program is achieving its objectives. Scholars will travel to Denver for the PRIDE summer academies for 2 consecutive years and to Aspen for a face-to-face mid-year meeting at the Annual Tom Petty Aspen Lung Conference. By using the combination of coaching and social science practices such as cultural capital and communities of practice that allow team members to feel connected with each other, and pairing the scholars with distinguished pulmonary and BiPM faculty mentors, we will ensure their academic persistence and ultimate success.