Nevada Center of Biomedical Research Excellence in Molecular and Cellular Signal Transduction in the Cardiovascular System

内华达心血管系统分子和细胞信号转导生物医学卓越研究中心

• 批准号: 10077852
• 负责人: Scott Earley
• 金额: $ 215.85万
• 依托单位: UNIVERSITY OF NEVADA RENO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10077852
• 关键词: Aging; Animal Model; Area; Back; Basic Science; Cardiac Myocytes; Cardiovascular Diseases; Cardiovascular Physiology; Cardiovascular system; Cause of Death; Cell Surface Receptors; Cell physiology; Centers of Research Excellence; Collaborations; Communities; Coupling; Development; Disease; Endothelial Cells; Environment; Epigenetic Process; Foundations; Funding; Genotype; Goals; Grant; Health; Healthcare Systems; Human; Image; Individual; Infrastructure; Institutes; Interdisciplinary Study; International; Ion Channel; Journals; Lead; Leadership; Link; Medical; Mentors; Methodology; Mission; Molecular; Neurons; Nevada; Pharmacology; Phase; Phenotype; Population; Principal Investigator; Program Research Project Grants; Publications; Publishing; Records; Reporting; Research; Research Infrastructure; Research Personnel; Research Project Grants; Role; Scientist; Signal Transduction; Signal Transduction Pathway; Smooth Muscle Myocytes; Source; Time; Transgenic Animals; United States National Institutes of Health; Universities; Work; career; collaborative environment; common treatment; disability; improved; innovation; insight; interest; medical schools; member; multidisciplinary; novel; professor; programs; temporal measurement; therapeutic development

Project Summary The goal of this new Phase I Center of Biomedical Research Excellence (COBRE) proposal is to establish and develop a new interdisciplinary research Center within the University of Nevada, Reno (UNR), and the UNR School of Medicine (UNR Med) that is focused on fundamental molecular and cellular signal transduction mechanisms within the cardiovascular system. This COBRE will be unique, as there are no existing centers or institutes with a focus on basic cardiovascular research within the State of Nevada. The unifying scientific theme of the new COBRE is the discovery and characterization of novel molecular and cellular signaling mechanisms that regulate the cardiovascular system in health and disease. This research mission is significant, because cardiovascular diseases remain the leading causes of death and disability in the US and much of the world. We expect that COBRE-sponsored research programs will develop deep insight into the basic molecular and cellular signaling mechanisms that regulate cardiovascular function, thereby accelerating the rate of discovery of new treatments for common cardiovascular diseases and ultimately improving human health. The primary function of Phase I is to provide mentoring and support for COBRE’s Project Leaders, a group of four promising early-stage investigators, with the goal of developing them into fully established research scientists funded by independent Research Program Grants (RPGs), such as an NIH R01 or equivalent. The COBRE will also improve the research infrastructure at UNR and UNR Med by establishing and developing two new research cores—the Transgenic Animal Genotyping and Phenotyping Core (Core B) and the High Spatial and Temporal Resolution Imaging Core (Core C)—to serve the needs of the Project Leaders and the wider research community. Phase I of the COBRE will lay the groundwork for long-term sustainability of the Center by increasing the number of RPG-supported investigators within the thematic focus at UNR and UNR Med, and by promoting collaborations among these investigators to stimulate the development of new multi-PI R01s and Program Project Grants. Dr. Scott Earley, Professor of Pharmacology at UNR Med, is the Principal Investigator and COBRE Director. Dr. Earley is an accomplished investigator with an established track record of NIH R01 funding and publication in high-quality journals. Additional scientific leadership will be provided by a group of four outstanding established investigators with common interests in ion channels, localized Ca2+ signaling, intracellular signal transduction pathways, transgenic animal models, endothelial cell function, epigenetics, novel cell surface receptors, neuronal cardiovascular control, localized signaling domains, and excitation/contraction coupling in cardiomyocytes and smooth muscle cells. Successful completion of the objectives of Phase I will establish the Nevada COBRE in Molecular and Cellular Signal Transduction in the Cardiovascular System as a sustainable multidisciplinary research Center with a critical mass of investigators working within this thematic focus.

项目摘要 这一新的第一阶段生物医学研究卓越中心(COBRE)提案的目标是建立和 在内华达大学雷诺分校(UNR)和UNR内部建立一个新的跨学科研究中心 医学院(UNR Med)，专注于基础分子和细胞信号转导 心血管系统内的机制。这个眼镜蛇将是独一无二的，因为没有现有的中心或 内华达州内专注于基础心血管研究的研究所。统一的科学主题 新的Cobre的发现和表征是新的分子和细胞信号机制 在健康和疾病中调节心血管系统。这项研究任务意义重大，因为 在美国和世界大部分地区，心血管疾病仍然是导致死亡和残疾的主要原因。我们 预计科布雷赞助的研究计划将发展对基础分子和细胞的深入洞察 调节心血管功能的信号机制，从而加快新发现的速度 治疗常见心血管疾病，并最终改善人类健康。的主要功能 第一阶段是为Cobre的项目负责人提供指导和支持，这是一个由四个有希望的早期阶段组成的小组 研究人员，目标是将他们发展成为独立资助的成熟的研究科学家 研究计划补助金(RPG)，如NIH R01或同等资助金。科布雷还将改进 通过建立和开发两个新的研究核心-- 转基因动物基因分型和表型分型核心(核心B)和高时空分辨率 成像核心(核心C)-服务于项目负责人和更广泛的研究社区的需求。第一阶段 将为中心的长期可持续性奠定基础，方法是增加 在联合国志愿人员方案和联合国志愿人员方案医学中心的专题重点内，并通过促进合作，由RPG支持的调查员 在这些研究人员中，刺激开发新的多PI R01和计划项目赠款。Dr。 斯科特·厄利，UNR Med的药理学教授，是Cobre的首席研究员和主任。Dr。 Earley是一位成就卓著的调查员，在NIH R01的资助和出版方面有着良好的记录 高质量的期刊。额外的科学领导将由一个由四个杰出的已建立的小组提供 对离子通道、局部钙信号、细胞内信号转导有共同兴趣的研究人员 途径，转基因动物模型，内皮细胞功能，表观遗传学，新型细胞表面受体，神经元 心血管控制、局部信号域和心肌细胞的兴奋/收缩偶联 平滑的肌肉细胞。成功完成第一阶段的目标将在#年建立内华达眼镜蛇 心血管系统中的分子和细胞信号转导作为一个可持续的多学科 研究中心有足够多的研究人员在这一主题范围内工作。