Cancer genes: translating basics to applications

癌症基因：将基础知识转化为应用

• 批准号: 10079474
• 负责人: PETER K VOGT
• 金额: $ 115.41万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-01-08 至 2022-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10079474
• 关键词: 1-Phosphatidylinositol 3-Kinase; Clinical Medicine; Complex; Cryoelectron Microscopy; Knowledge; Malignant Neoplasms; Molecular; Oncogenes; Oncogenic; Oncoproteins; Pathway interactions; Proteomics; Stimulus; Structure; Techniques; Translating; Translations; Untranslated RNA; mutant; novel; public health relevance; tumorigenesis

 DESCRIPTION (provided by applicant): The proposal focuses on molecular mechanisms of oncogenesis. It includes three major projects. The first deals with lncRNAs (long non-coding RNAs) that are specifically regulated by the oncoprotein MYC and by the oncogenic H1047R mutant of p110a of PI3K (phosphatidylinositol 3-kinase). The second focuses on the application of a novel and quantitative proteomic technique, QBID, to determine stimulus-specific changes in the interactomes in the PI3K pathway. The third project consists of a structural analysis of the p110-p85 complex of PI3K. Each of these projects is highly and directly cancer-relevant. Progress on these fronts will have an impact on the translation of basic knowledge into clinical medicine.

 描述（由申请人提供）：该提案侧重于肿瘤发生的分子机制。它包括三个主要项目。第一个涉及lncRNA（长链非编码RNA），它由癌蛋白MYC和PI 3 K（磷脂酰肌醇3-激酶）p110 a的致癌H1047 R突变体特异性调节。第二个重点是应用一种新的和定量的蛋白质组学技术，QBID，以确定刺激特定的变化在PI 3 K通路的相互作用。第三个项目包括对 PI 3 K的p110-p85复合物。这些项目中的每一个都与癌症高度直接相关。这些方面的进展将对将基础知识转化为临床医学产生影响。