Cancer genes: translating basics to applications
Cancer genes: translating basics to applications
批准号:
10079474
负责人:
PETER K VOGT
金额:
$115.41万
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
已结题
起止时间:
2016-01-08 至 2022-12-31
中文摘要
点击翻译按钮获取中文摘要
英文摘要
DESCRIPTION (provided by applicant): The proposal focuses on molecular mechanisms of oncogenesis. It includes three major projects. The first deals with lncRNAs (long non-coding RNAs) that are specifically regulated by the oncoprotein MYC and by the oncogenic H1047R mutant of p110a of PI3K (phosphatidylinositol 3-kinase). The second focuses on the application of a novel and quantitative proteomic technique, QBID, to determine stimulus-specific changes in the interactomes in the PI3K pathway. The third project consists of a structural analysis of the
p110-p85 complex of PI3K. Each of these projects is highly and directly cancer-relevant. Progress on these fronts will have an impact on the translation of basic knowledge into clinical medicine.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Cancer genes: translating basics to applications
-
批准号:10322977
-
项目类别:
-
资助金额:$108.22万
-
财政年份:2016
-
负责人:PETER K VOGT
-
依托单位:
Inhibition of TOR and de novo protein synthesis: a pulsed SILAC database
-
批准号:8328955
-
项目类别:
-
资助金额:$23.69万
-
财政年份:2011
-
负责人:PETER K VOGT
-
依托单位:
Inhibition of TOR and de novo protein synthesis: a pulsed SILAC database
-
批准号:8240894
-
项目类别:
-
资助金额:$28.43万
-
财政年份:2011
-
负责人:PETER K VOGT
-
依托单位:
The Antisense Transcriptome and the Epigenetics of Cancer.
-
批准号:8117311
-
项目类别:
-
资助金额:$30.58万
-
财政年份:2010
-
负责人:PETER K VOGT
-
依托单位:
Activation of silenced tumor suppressor genes by non-coding RNA
-
批准号:8676713
-
项目类别:
-
资助金额:$37.08万
-
财政年份:2010
-
负责人:PETER K VOGT
-
依托单位:
The Antisense Transcriptome and the Epigenetics of Cancer.
-
批准号:8468130
-
项目类别:
-
资助金额:$28.74万
-
财政年份:2010
-
负责人:PETER K VOGT
-
依托单位:
Activation of silenced tumor suppressor genes by non-coding RNA
-
批准号:8257160
-
项目类别:
-
资助金额:$38.22万
-
财政年份:2010
-
负责人:PETER K VOGT
-
依托单位:
Activation of silenced tumor suppressor genes by non-coding RNA
-
批准号:8096834
-
项目类别:
-
资助金额:$38.22万
-
财政年份:2010
-
负责人:PETER K VOGT
-
依托单位:
Activation of silenced tumor suppressor genes by non-coding RNA
-
批准号:8473177
-
项目类别:
-
资助金额:$35.93万
-
财政年份:2010
-
负责人:PETER K VOGT
-
依托单位:
SMALL MOLECULES REGULATING PROTEIN-PROTEIN INTERACTIONS IN CANCER
-
批准号:8169361
-
项目类别:
-
资助金额:$3.35万
-
财政年份:2010
-
负责人:PETER K VOGT
-
依托单位:
The Antisense Transcriptome and the Epigenetics of Cancer.
-
批准号:8257161
-
项目类别:
-
资助金额:$30.58万
-
财政年份:2010
-
负责人:PETER K VOGT
-
依托单位:
SMALL MOLECULES REGULATING PROTEIN-PROTEIN INTERACTIONS IN CANCER
-
批准号:7955284
-
项目类别:
-
资助金额:$0.32万
-
财政年份:2009
-
负责人:PETER K VOGT
-
依托单位:
TARGET-GUIDED DEVELOPMENT OF SPECIFIC AKT INHIBITORS
-
批准号:7501424
-
项目类别:
-
资助金额:$42.33万
-
财政年份:2005
-
负责人:PETER K VOGT
-
依托单位:
TARGET-GUIDED DEVELOPMENT OF SPECIFIC AKT INHIBITORS
-
批准号:7244228
-
项目类别:
-
资助金额:$43.51万
-
财政年份:2005
-
负责人:PETER K VOGT
-
依托单位:
Controlling the Max Network
-
批准号:6954125
-
项目类别:
-
资助金额:$25.34万
-
财政年份:2004
-
负责人:PETER K VOGT
-
依托单位:
Controlling the Max Network
-
批准号:7122797
-
项目类别:
-
资助金额:$24.74万
-
财政年份:2004
-
负责人:PETER K VOGT
-
依托单位:
Controlling the Max Network
-
批准号:7452399
-
项目类别:
-
资助金额:$24.26万
-
财政年份:2004
-
负责人:PETER K VOGT
-
依托单位:
Administrative Core
-
批准号:6990250
-
项目类别:
-
资助金额:$3.8万
-
财政年份:2004
-
负责人:PETER K VOGT
-
依托单位:
Combinatorial Chemical Libraries and Cancer Targets
-
批准号:6990226
-
项目类别:
-
资助金额:$17.1万
-
财政年份:2004
-
负责人:PETER K VOGT
-
依托单位:
Controlling the Max Network
-
批准号:7254917
-
项目类别:
-
资助金额:$24.03万
-
财政年份:2004
-
负责人:PETER K VOGT
-
依托单位:
海外基金