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Cancer genes: translating basics to applications

Cancer genes: translating basics to applications
癌症基因:将基础知识转化为应用
批准号:
10079474
负责人:
PETER K VOGT
金额:
$115.41万
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
已结题
起止时间:
2016-01-08 至 2022-12-31

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中文摘要
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英文摘要
 DESCRIPTION (provided by applicant): The proposal focuses on molecular mechanisms of oncogenesis. It includes three major projects. The first deals with lncRNAs (long non-coding RNAs) that are specifically regulated by the oncoprotein MYC and by the oncogenic H1047R mutant of p110a of PI3K (phosphatidylinositol 3-kinase). The second focuses on the application of a novel and quantitative proteomic technique, QBID, to determine stimulus-specific changes in the interactomes in the PI3K pathway. The third project consists of a structural analysis of the p110-p85 complex of PI3K. Each of these projects is highly and directly cancer-relevant. Progress on these fronts will have an impact on the translation of basic knowledge into clinical medicine.
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Cancer genes: translating basics to applications
  • 批准号:
    10322977
  • 项目类别:
  • 资助金额:
    $108.22万
  • 财政年份:
    2016
  • 负责人:
    PETER K VOGT
  • 依托单位:
Inhibition of TOR and de novo protein synthesis: a pulsed SILAC database
  • 批准号:
    8328955
  • 项目类别:
  • 资助金额:
    $23.69万
  • 财政年份:
    2011
  • 负责人:
    PETER K VOGT
  • 依托单位:
Inhibition of TOR and de novo protein synthesis: a pulsed SILAC database
  • 批准号:
    8240894
  • 项目类别:
  • 资助金额:
    $28.43万
  • 财政年份:
    2011
  • 负责人:
    PETER K VOGT
  • 依托单位:
The Antisense Transcriptome and the Epigenetics of Cancer.
  • 批准号:
    8117311
  • 项目类别:
  • 资助金额:
    $30.58万
  • 财政年份:
    2010
  • 负责人:
    PETER K VOGT
  • 依托单位:
海外基金