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Cancer genes: translating basics to applications

Cancer genes: translating basics to applications
癌症基因:将基础知识转化为应用
批准号:
10322977
负责人:
PETER K VOGT
金额:
$108.22万
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
已结题
起止时间:
2016-01-08 至 2023-04-30

项目摘要

项目成果

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中文摘要
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英文摘要
 DESCRIPTION (provided by applicant): The proposal focuses on molecular mechanisms of oncogenesis. It includes three major projects. The first deals with lncRNAs (long non-coding RNAs) that are specifically regulated by the oncoprotein MYC and by the oncogenic H1047R mutant of p110a of PI3K (phosphatidylinositol 3-kinase). The second focuses on the application of a novel and quantitative proteomic technique, QBID, to determine stimulus-specific changes in the interactomes in the PI3K pathway. The third project consists of a structural analysis of the p110-p85 complex of PI3K. Each of these projects is highly and directly cancer-relevant. Progress on these fronts will have an impact on the translation of basic knowledge into clinical medicine.
期刊论文(17)
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科研奖励(0)
会议论文
DOI: 10.1038/s41557-021-00660-y
发表时间: 2021-06
期刊: Nature chemistry
影响因子: 21.8
作者: [Favalli N, Bassi G, Pellegrino C, Millul J, De Luca R, Cazzamalli S, Yang S, Trenner A, Mozaffari NL, Myburgh R, Moroglu M, Conway SJ, Sartori AA, Manz MG, Lerner RA, Vogt PK, Scheuermann J, Neri D]
通讯作者: Neri D
DOI: 10.1146/annurev-virology-092818-015828
发表时间: 2019-09
期刊: Annual review of virology
影响因子: 11.3
作者: [P. Vogt]
通讯作者: P. Vogt
DOI: 10.1016/j.bmc.2018.07.019
发表时间: 2018-08-07
期刊: Bioorganic & medicinal chemistry
影响因子: 3.5
作者: [Jacob NT, Miranda PO, Shirey RJ, Gautam R, Zhou B, de Orbe Izquierdo ME, Hixon MS, Hart JR, Ueno L, Vogt PK, Janda KD]
通讯作者: Janda KD
DOI: 10.1038/s41419-023-05683-6
发表时间: 2023-02-27
期刊: CELL DEATH & DISEASE
影响因子: 9
作者: [Garcia-Caballero, Daniel, Hart, Jonathan R., Vogt, Peter K.]
通讯作者: Vogt, Peter K.
12
    Cancer genes: translating basics to applications
    • 批准号:
      10079474
    • 项目类别:
    • 资助金额:
      $115.41万
    • 财政年份:
      2016
    • 负责人:
      PETER K VOGT
    • 依托单位:
    Inhibition of TOR and de novo protein synthesis: a pulsed SILAC database
    • 批准号:
      8328955
    • 项目类别:
    • 资助金额:
      $23.69万
    • 财政年份:
      2011
    • 负责人:
      PETER K VOGT
    • 依托单位:
    Inhibition of TOR and de novo protein synthesis: a pulsed SILAC database
    • 批准号:
      8240894
    • 项目类别:
    • 资助金额:
      $28.43万
    • 财政年份:
      2011
    • 负责人:
      PETER K VOGT
    • 依托单位:
    The Antisense Transcriptome and the Epigenetics of Cancer.
    • 批准号:
      8117311
    • 项目类别:
    • 资助金额:
      $30.58万
    • 财政年份:
      2010
    • 负责人:
      PETER K VOGT
    • 依托单位:
    海外基金