Cancer genes: translating basics to applications

癌症基因：将基础知识转化为应用

• 批准号: 10322977
• 负责人: PETER K VOGT
• 金额: $ 108.22万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-01-08 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10322977
• 关键词: 1-Phosphatidylinositol 3-Kinase; Clinical Medicine; Complex; Cryoelectron Microscopy; Knowledge; Malignant Neoplasms; Molecular; Oncogenes; Oncogenic; Oncoproteins; Pathway interactions; Proteomics; Stimulus; Structure; Techniques; Translating; Translations; Untranslated RNA; mutant; novel; public health relevance; tumorigenesis

 DESCRIPTION (provided by applicant): The proposal focuses on molecular mechanisms of oncogenesis. It includes three major projects. The first deals with lncRNAs (long non-coding RNAs) that are specifically regulated by the oncoprotein MYC and by the oncogenic H1047R mutant of p110a of PI3K (phosphatidylinositol 3-kinase). The second focuses on the application of a novel and quantitative proteomic technique, QBID, to determine stimulus-specific changes in the interactomes in the PI3K pathway. The third project consists of a structural analysis of the p110-p85 complex of PI3K. Each of these projects is highly and directly cancer-relevant. Progress on these fronts will have an impact on the translation of basic knowledge into clinical medicine.

 描述（应用程序提供）：该提案的重点是肿瘤发生的分子机制。它包括三个主要项目。第一批涉及由癌蛋白MYC和PI3K（磷脂酰迪糖醇3-激酶）的p110a的致癌H1047R突变体特异性调节的LNCRNA（长非编码RNA）。第二个重点是应用新颖和定量的蛋白质组学技术QBID来确定PI3K途径中相互作用体的刺激特异性变化。第三个项目包括对 P110-P85 PI3K的复合物。这些项目中的每一个都高度与癌症直接相关。这些方面的进展将影响将基础知识转化为临床医学。

项目成果

From Viruses to Genes to Cells.

• DOI: 10.1146/annurev-virology-092818-015828
• 发表时间: 2019-09
• 期刊: Annual review of virology
• 影响因子: 11.3
• 作者: P. Vogt

Stereo- and regiodefined DNA-encoded chemical libraries enable efficient tumour-targeting applications.

• DOI: 10.1038/s41557-021-00660-y
• 发表时间: 2021-06
• 期刊: Nature chemistry
• 影响因子: 21.8
• 作者: Favalli N;Bassi G;Pellegrino C;Millul J;De Luca R;Cazzamalli S;Yang S;Trenner A;Mozaffari NL;Myburgh R;Moroglu M;Conway SJ;Sartori AA;Manz MG;Lerner RA;Vogt PK;Scheuermann J;Neri D
• 通讯作者: Neri D

The MYC-regulated lncRNA LNROP (ENSG00000254887) enables MYC-driven cell proliferation by controlling the expression of OCT2.

• DOI: 10.1038/s41419-023-05683-6
• 发表时间: 2023-02-27
• 期刊: CELL DEATH & DISEASE
• 影响因子: 9
• 作者: Garcia-Caballero, Daniel;Hart, Jonathan R.;Vogt, Peter K.
• 通讯作者: Vogt, Peter K.

Long Non-Coding RNAs as "MYC Facilitators".

• DOI: 10.3390/pathophysiology30030030
• 发表时间: 2023-09-01
• 期刊: Pathophysiology : the official journal of the International Society for Pathophysiology
• 作者: García-Caballero D;Hart JR;Vogt PK
• 通讯作者: Vogt PK

Synthetic molecules for disruption of the MYC protein-protein interface.

• DOI: 10.1016/j.bmc.2018.07.019
• 发表时间: 2018-08-07
• 期刊: Bioorganic & medicinal chemistry
• 影响因子: 3.5
• 作者: Jacob NT;Miranda PO;Shirey RJ;Gautam R;Zhou B;de Orbe Izquierdo ME;Hixon MS;Hart JR;Ueno L;Vogt PK;Janda KD
• 通讯作者: Janda KD