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Neural Mechanisms Underlying Self-Critical Rumination and Self-Reassurance and Suicidal Thoughts and Behavior in Youth

青少年自我批评沉思、自我安慰以及自杀想法和行为背后的神经机制

基本信息

批准号：
10117045
负责人：
Anastacia Yurievna Kudinova
金额：
$ 19.73万
依托单位：
EMMA PENDLETON BRADLEY HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-04-01 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10117045
关键词：
15 year old Address Adolescence Adolescent Adult Age Anterior Area Behavior Behavior Disorders Behavioral Mechanisms Biological Brain Cause of Death Child Collaborations Communities Compassion Complex Data Development Diagnostic Dimensions Dorsal Ecological momentary assessment Environment Feeling suicidal Female Female Adolescents Frequencies Functional Magnetic Resonance Imaging Future Goals Human Image Impairment Individual Inflammatory Response Insula of Reil Intervention Investigation K-Series Research Career Programs Laboratories Length Life Link Mental disorders Mentors Mentorship Methodology Mood Disorders National Institute of Mental Health Neurobiology Play Prefrontal Cortex Prevalence Prevention Research Price Process Psychiatry Psychopathology Psychophysiology Published Comment Research Research Personnel Rest Role Sampling Self Assessment Self-Examination Series Severities Sex Differences Stress Suicide Suicide prevention Symptoms Techniques Technology Assessment Teenagers Testing Thinking Training Universities Work Youth age group base biobehavior brain behavior career development cingulate cortex critical developmental period critical period environmental change experience girls imaging approach in vivo innovation interest male neural circuit neuroimaging neuromechanism novel peer preventive intervention programs prospective psychosocial recruit relating to nervous system skills suicidal behavior suicidal risk suicide rate young adult

项目摘要

Suicide is the second leading cause of death among 10-34 year-olds. Aligning with the NIMH's Prioritized Agenda for Suicide Prevention Research, this K23 career development award seeks to advance what is known about the brain/behavior mechanisms underlying self-critical rumination ─ defined as persistent negative-self- evaluation ─ and self-reassurance ─ providing compassion to self. This K23's central hypothesis is that circuit alterations in the dorsolateral and dorsomedial prefrontal cortex, dorsal anterior cingulate, and insula underlying self-critical rumination and self-reassurance is associated with increased suicidal thoughts and behavior (STB) in adolescents. Our central methodology is to examine self-critical rumination and self- reassurance using task-dependent and task-independent functional magnetic resonance imaging (fMRI) and ecological momentary assessment (EMA) in 90 12-15 year-old girls recruited on the range of STB. This age group represents a critical developmental period for these self-referential processes and youth in this age- group experienced a sharp increase in suicide rates over the last decade. Our focus on only girls is due to greater prevalence of self-criticism among females compared to males, but we plan to examine potential sex- differences in future studies. This K23's research goals are to: (i) test the associations between in vivo self- critical rumination, self-reassurance, and STB; (ii) identify neural mechanisms underlying self-critical rumination and self-reassurance; (iii) integrate the findings from the scanner with STB assessed in adolescents' real world environment. This K23's career development goals are to gain hands-on mentorship with (i) task-dependent and task-independent fMRI to assess circuit function; (ii) EMA for better real-world assessment of self-critical rumination and self-reassurance; (iii) statistical approaches for imaging and EMA data; (iv) professional development and collaboration skills. This K23 is significant, because identifying specific neural mechanisms underlying the interplay between self-critical rumination, self-reassurance, and STB can help ascertain which teens are at a greater risk for STB and contribute to development of novel, mechanistically-informed interventions. This study, combined with the completion of proposed training goals, will effectively propel the candidate towards establishing an independent program of research focused on identifying bio-behavioral mechanisms and developing preventative interventions for youth suicide risk. This K23 is innovative because this will be the first project to identify specific neural mechanisms of self-critical rumination and self- reassurance in adolescents focusing on: (i) identifying construct-specific neural mechanisms; (ii) a trans- diagnostic sample of teenagers selected on the range of STB; (iii) integration of imaging and EMA techniques. The proposed mentors (Drs. Dickstein, Armey, Jones, and Brick) and consultants (Drs. Price and Maratos) have extensive experience to support the proposed training goals. The Department of Psychiatry and Human Behavior at Brown University is an outstanding environment for the proposed training and research.

自杀是10-34岁人群的第二大死因。与NIMH的优先级保持一致自杀预防研究议程，这个K23职业发展奖旨在推动已知的关于自我批评反刍的大脑/行为机制-定义为持续的消极自我- 评价和自我保证，对自己表示同情。K23的核心假设是，背外侧和背内侧前额叶皮层、背侧前扣带回和背侧前扣带回的回路改变潜在的自我批评沉思和自我安慰与自杀想法的增加有关，青少年行为（STB）。我们的中心方法是检查自我批评的沉思和自我- 使用任务依赖性和任务无关性功能性磁共振成像（fMRI）的保证，在STB范围内招募90名12-15岁女孩进行生态瞬时评估（EMA）。这个年龄组代表了一个关键的发展时期，这些自我参照的过程和青年在这个年龄- 在过去的十年里，这个群体的自杀率急剧上升。我们只关注女孩是因为与男性相比，女性自我批评的比例更高，但我们计划研究潜在的性- 未来研究的差异。该K23的研究目标是：（i）测试体内自我- 批判性反刍，自我保证，和STB;（ii）确定自我批判性反刍的神经机制（iii）将扫描仪的结果与青少年真实的世界中的STB评估相结合环境K23的职业发展目标是通过以下方式获得实践指导：（i）任务相关和任务无关的功能磁共振成像，以评估电路功能;（ii）EMA更好地评估自我批评的现实世界反刍和自我保证;（iii）成像和EMA数据的统计方法;（iv）专业发展和协作技能。这个K23很重要，因为确定特定的神经机制自我批评的沉思，自我保证和STB之间的相互作用可以帮助确定青少年患STB的风险更大，并有助于发展新的、机械式的知识，干预措施。本研究结合培训目标的完成，将有力地推动候选人对建立一个独立的研究计划，重点是确定生物行为机制，并制定预防措施，预防青年自杀风险。K23是创新的，因为这将是第一个确定自我批评沉思和自我反思的特定神经机制的项目在青少年的保证，重点是：（一）确定特定结构的神经机制;（二）一个跨- STB范围内选择的青少年诊断样本;（iii）成像和EMA技术的整合。建议的导师（Dickstein博士、Armey博士、Jones博士和Brick博士）和顾问（Price博士和Maratos博士）有丰富的经验，以支持拟议的培训目标。精神病学和人类学系布朗大学的行为是拟议的培训和研究的优秀环境。