Earliest predictors of language outcomes in high-risk infants

高危婴儿语言结果的最早预测因素

• 批准号: 10116363
• 负责人: Lisa Leigh Hunter
• 金额: $ 66.7万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10116363
• 关键词: 3 year old; Age; Auditory; Auditory Evoked Potentials; Biological Markers; Birth; Brain; Child; Cochlear implant procedure; Communication; Demographic Factors; Detection; Development; Diffuse; Diffusion Magnetic Resonance Imaging; Early Intervention; Early identification; Electroencephalography; Enrollment; Frequencies; Functional Magnetic Resonance Imaging; Funding; Gestational Age; Goals; Hearing; Hearing Tests; Hearing problem; High-Frequency Hearing Loss; Impairment; Infant; Intervention; Language; Language Disorders; Language Therapy; Life; Longitudinal cohort; Magnetic Resonance Imaging; Measures; Methods; Modeling; National Institute of Neurological Disorders and Stroke; Neonatal; Neurodevelopmental Disorder; Neuronal Plasticity; Newborn Infant; Nursery Schools; Outcome; Outcome Measure; Perinatal; Physiological; Premature Birth; Premature Infant; Prevalence; Prognostic Marker; Prospective Studies; Rest; Risk; Risk Factors; Sampling; Scanning; Services; Speech; Speech Disorders; Stimulus; Structure; Survivors; Therapeutic Studies; hearing impairment; hearing screening; high risk; high risk infant; improved; innovation; language outcome; literacy; neurodevelopment; novel; otoacoustic emission; permanent hearing loss; predictive modeling; response; screening; speech processing; study population; white matter

One in every nine babies in the US is born preterm. Speech, language and hearing disorders (SLD) are among the most prevalent neurodevelopmental disorders in children, especially among very preterm survivors. About 40% of very preterm infants (≤32 weeks gestational age) develop speech-language disorders while 10% have permanent hearing loss, increasing the impact on communication difficulties. Currently, it is not possible to accurately predict in the first several years of life which children will develop speech-language disorders, and speech- language therapy is the most delayed of any intervention provided to preterm infants. Such an advance would facilitate early intervention and research therapies during critical windows of optimal neuroplasticity. Our central hypothesis is that prediction of speech-language disorders is possible by 3 m corrected age (CA) with combined innovative measures of structural and functional brain connectivity with magnetic resonance imaging, evoked response measures of speech processing, and novel, sensitized hearing measures. Primary aims are to (1) Identify biomarkers of brain connectivity deficits in very preterm infants that predict SLD; (2) Identify impaired speech processing and all degrees of hearing loss in very preterm infants; and (3) Develop predictive models using advanced biomarkers in preterm infants for adverse speech, language and pre-literacy outcomes at 2 and 3 years CA. This proposal will enroll very preterm infants in a prospective study that will complete comprehensive speech-language and pre- literacy assessments at 2 and 3 years CA. and 36 m CA. The overarching goal is to develop a robust prediction model using innovative measures to enable early identification of children at high risk for SLD.

在美国，每九个婴儿中就有一个早产。言语、语言和听力障碍 (SLD)是儿童中最普遍的神经发育障碍之一，尤其是 早产儿幸存者中。约40%的极早产儿（胎龄≤32周） 10%的人患有语言障碍，而10%的人患有永久性听力损失， 影响沟通困难。目前，还无法准确预测第一次 几年的生活，儿童将发展语言障碍，和语言- 语言治疗是对早产儿提供的所有干预措施中最延迟的。这样的 这一进展将有助于在关键窗口期进行早期干预和研究治疗， 最佳神经可塑性我们的中心假设是，言语语言障碍的预测是 可能通过3 m校正年龄（CA）结合结构和 功能性脑连接与磁共振成像，诱发反应的措施， 语音处理，以及新的，敏感的听力措施。主要目的是（1）确定 预测SLD的极早产儿脑连接缺陷的生物标志物;（2）识别 极早产儿的言语处理受损和各种程度的听力损失;以及（3） 在早产儿中使用先进的生物标志物开发不良言语的预测模型， 在2年和3年的CA语言和识字前的成果。这项提案将招收早产儿 在一项前瞻性研究中，婴儿将完成全面的语言和学前教育， 在2年和3年的扫盲评估。36米。总体目标是开发一个 采用创新措施的强有力预测模型， SLD风险高。