Continuous wearable monitor for the detection and release of Freezing of Gait

项目摘要/摘要 建议的是一个日常社区内使用的系统，该系统可以检测雾的发生并触发外部 暗示刺激来解冻个体。意义：帕金森氏症(PD)影响着100多万人 美国人将其列为美国第二常见的神经退行性疾病。它的流行率是 预计到2040年将翻一番。超过30%的帕金森病患者会出现步态冻结(雾)， 症状特征为发作性的步态启动能力障碍和自发性呼吸暂停 行走过程中的运动。雾的一个奇怪的特征是当外部感官时它可以被克服 给出了刺激(线索)。研究表明，如果线索是外在呈现的，那么 雾事件大大减少。假设：我们假设易于使用、准确、外生的排队 对于雾事件的响应将缩短这些事件的持续时间，并最终导致质量的提高 生活。具体目标：在第二阶段，IDL及其合作者将：(1)开发一个生产就绪系统，(2) 为建议的系统开发配套的移动应用程序，并改进之前开发的雾检测 (3)验证了系统的正确运行，并通过实验室和现场实验验证了系统的有效性。 社区测试。

Project Summary/Abstract Proposed is a system for daily in-community use that detects the occurrence of FOG and triggers external cueing stimuli to unfreeze the individual. Significance: Parkinson's disease (PD) affects more than one million Americans making it the second-most common neurodegenerative disorder in the US. Its prevalence is expected to double by 2040. More than 30% of all people with PD will develop Freezing of Gait (FOG), a symptom characterized by episodic impairments in the ability to initiate gait and the spontaneous arrest of movement during walking. A curious feature of FOG is that it can be overcome when an external sensory stimulus (cue) is presented. Research has shown that if the cue is exogenously presented, the incidence of FOG events is greatly reduced. Hypothesis: We hypothesize that easy to use, accurate, exogenous queuing in response to FOG events will decrease duration of these events and ultimately lead to improved quality of life. Specific Aims: In Phase II IDL and its collaborators will: (1) Develop a production ready system, (2) Develop a companion mobile app for the proposed system and refine previously developed FOG detection algorithms, and (3) Validate the proper operation of the system and demonstrate its efficacy through lab and in- community testing.