A Nociceptin Central Amygdala to Hindbrain Circuit for the Control of Palatable Food Consumption

用于控制可口食物消耗的伤害感受肽中央杏仁核到后脑回路

基本信息

项目摘要

Project Summary Candidate: I am an NIH T32 Postdoctoral Fellow within the Bowles Center for Alcohol Studies and the UNC Center of Excellence for Eating Disorders in the Departments of Pharmacology and Psychiatry at the University of North Carolina at Chapel Hill. Career Goals: My ultimate goal is to understand the neural circuits that regulate palatable food intake that contribute to diseases like obesity and binge eating disorder. By researching the underlying signaling pathways and molecular circuitry in these neurochemically defined neuron ensembles, I will develop targeted, novel preclinical treatments for obesity and binge eating disorder for testing in construct valid animal models of obesity and binge eating disorder. Career Development: My current expertise is in molecular neuroscience and genetics, so I hope to gain additional mentored training in 1) circuit neuroscience including photometry, advanced optogenetics, chemogenetics, and electrophysiology; 2) mouse operant behavior; and 3) clinical obesity phenotypes and metabolism within the current proposal. Research Project: This project leverages preliminary data that shows a specific role for prepronociceptin-expressing neurons in the central amygdala (PnocCeA neurons) in: promoting palatable food intake, modulating the severity of diet-induced obesity, and promoting reward through its inputs to the parabrachial nucleus (PBN) and nucleus of the solitary tract (NTS). I aim to 1) measure the dynamic activity state of PnocCeA neurons during operant palatable food intake using in vivo fiber photometry, 2) determine the role of nociceptin signaling in the PBN and NTS on neural activity and the requisite role of this pathway in operant palatable food intake, and 3) use pathway- specific inhibitory optogenetics and chemogenetics to probe the specific role of the PnocCeA pathway to the PBN and NTS during operant palatable food intake. In future independent applications (R01s), I will assess circuit and molecular plasticity of PnocCeA networks following chronic palatable food access and diet-induced obesity. Environment: Research will be primarily performed at the University of North Carolina at Chapel Hill with some experiments performed at the National Institute of Environmental Health Sciences research program at Research Triangle Park in Durham, NC. Mentorship: The core mentorship team consists of Dr. Thomas Kash, lead mentor, who is a leading researcher in circuit neuroscience and consummatory behavior, and Dr. Cynthia Bulik, co-lead mentor, who is a nationally renowned expert in obesity and eating disorder research. Dr. Kari North, a co-mentor, is a leading researcher in clinical obesity phenotyping and genetics. Dr. Joyce Besheer, a co-mentor, is a very experienced researcher in rodent operant behavior. Dr. Guohong Cui and Dr. Michael Krashes, both consultants, have equipment for and routinely use in vivo fiber photometry of genetically encoded Ca2+ indicators in awake, freely-behaving mice. Dr. Todd Thiele, a consultant, is an expert in neuropeptide signaling and local pharmacological manipulations during mouse behavior. Together, they will provide expertise to accomplish the scientific aims, mentorship for me to complete my training, and leadership to promote my transition to being an independent investigator.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
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James Andrew Hardaway其他文献

James Andrew Hardaway的其他文献

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{{ truncateString('James Andrew Hardaway', 18)}}的其他基金

Functional and Behavioral Characterization of Central Amygdala Glucagon Like Peptode-1 Receptors
中央杏仁核胰高血糖素样 Peptode-1 受体的功能和行为特征
  • 批准号:
    10286169
  • 财政年份:
    2021
  • 资助金额:
    $ 8.48万
  • 项目类别:
Functional and Behavioral Characterization of Central Amygdala Glucagon Like Peptode-1 Receptors
中央杏仁核胰高血糖素样 Peptode-1 受体的功能和行为特征
  • 批准号:
    10414577
  • 财政年份:
    2021
  • 资助金额:
    $ 8.48万
  • 项目类别:
Functional and Behavioral Characterization of Central Amygdala Glucagon Like Peptode-1 Receptors
中央杏仁核胰高血糖素样 Peptode-1 受体的功能和行为特征
  • 批准号:
    10414117
  • 财政年份:
    2021
  • 资助金额:
    $ 8.48万
  • 项目类别:
Functional and Behavioral Characterization of Central Amygdala Glucagon Like Peptode-1 Receptors
中央杏仁核胰高血糖素样 Peptode-1 受体的功能和行为特征
  • 批准号:
    10502881
  • 财政年份:
    2021
  • 资助金额:
    $ 8.48万
  • 项目类别:
A Nociceptin Central Amygdala to Hindbrain Circuit for the Control of Palatable Food Consumption
用于控制可口食物消耗的伤害感受肽中央杏仁核到后脑回路
  • 批准号:
    10413010
  • 财政年份:
    2020
  • 资助金额:
    $ 8.48万
  • 项目类别:
A Nociceptin Central Amygdala to Hindbrain Circuit for the Control of Palatable Food Consumption
用于控制可口食物消耗的伤害感受肽中央杏仁核到后脑回路
  • 批准号:
    10159256
  • 财政年份:
    2020
  • 资助金额:
    $ 8.48万
  • 项目类别:
Presynaptic Mechanisms Regulating the Dopamine Transporter
调节多巴胺转运蛋白的突触前机制
  • 批准号:
    8207320
  • 财政年份:
    2010
  • 资助金额:
    $ 8.48万
  • 项目类别:
Presynaptic Mechanisms Regulating the Dopamine Transporter
调节多巴胺转运蛋白的突触前机制
  • 批准号:
    8061759
  • 财政年份:
    2010
  • 资助金额:
    $ 8.48万
  • 项目类别:
Presynaptic Mechanisms Regulating the Dopamine Transporter
调节多巴胺转运蛋白的突触前机制
  • 批准号:
    8387035
  • 财政年份:
    2010
  • 资助金额:
    $ 8.48万
  • 项目类别:

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