Superomniphobic flow controlled prosthetic heart valve

超全疏流控制人工心脏瓣膜

• 批准号: 10127145
• 负责人: Lakshmi Prasad Dasi
• 金额: $ 4.07万
• 依托单位: GEORGIA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-12-05 至 2021-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10127145
• 关键词: Superomniphobic; flow; controlled; prosthetic; heart

Project Summary: All present day prosthetic heart valves suffer from complications. Mechanical heart valves (HVs) require life-long anti-coagulation therapy, while bioprosthetic heart valves based on fixed tissue are plagued with durability, immunogenic and calcification issues. Superomniphobic (SO) bileaflet mechanical heart valves with vortex generator (VG) technology promise to eliminate the need for anti-coagulation therapy. Our lab has developed a SO bileaflet mechanical heart valve (BMHV) with VGs that drastically improve surface hemocompatibility as well as eliminate turbulent stresses, thus reducing platelet activation. Preliminary work has shown that SO surfaces remarkably reduced thrombogenic potential relative to plain pyrolytic carbon leaflets. Further, we have already demonstrated the feasibility of manufacturing BMHVs and assembling them with VGs into an implantable BMHV. The present R21 study aims to gauge the efficacy of SO BMHV with VG as a potential alternative to current heart valve technology by fine tuning material composition and processing to meet the durability and antithrombogenic requirements for heart valves. Our central hypothesis is: superomniphobic BMHVs with vortex generator flow control technology will be superior to current BMHVs in terms of hemodynamic performance, blood damage, and blood-material surface compatibility while exhibiting satisfactory durability. This is tested in two aims. Aim 1 quantifies heart valve hemodynamic performance of SO with VG BMHVs to identify the ideal SO+VG configuration for superior hemodynamics and minimum blood damage. Aim 2 focuses on elucidating the effects of leaflet composition and processing on hemocompatibility while optimizing the strength and hemocompatibility of the coating. This proposal is led by Dr. Lakshmi Prasad Dasi, who is a well trained young investigator with expertise in heart valve engineering and cardiovascular biomechanics, and inventor of several heart valve technologies including VGs and novel biomolecule polymer leaflets. Multi-PIs are Dr. Kota, who is an established superhydrophobic materials expert; Dr. Popat whose expertise lies in bio-compatibility and surface nano-engineering. If the proposed work demonstrates that SO with VG BMHVs elicit excellent hemodynamics, and are durable, this R21 grant may lead to breakthrough technology for mechanical HVs and all other blood contacting devices (e.g. artificial hearts, LVADs etc.) that require little or no anticoagulation.

项目概要： 目前所有的人工心脏瓣膜都存在并发症。机械心脏瓣膜 (HV) 需要终生使用 抗凝治疗，而基于固定组织的生物假体心脏瓣膜则存在耐久性问题， 免疫原性和钙化问题。带涡流的超全恐惧 (SO) 双叶机械心脏瓣膜 发电机（VG）技术有望消除抗凝治疗的需要。我们实验室开发了一个 带有 VG 的 SO 双叶机械心脏瓣膜 (BMHV)，可显着改善表面血液相容性 消除湍流应力，从而减少血小板活化。初步工作表明 SO 表面 与普通热解碳小叶相比，显着降低了血栓形成的可能性。此外，我们已经 展示了制造 BMHV 并将其与 VG 组装成植入式 BMHV 的可行性。 目前的 R21 研究旨在评估 SO BMHV 与 VG 作为当前心脏的潜在替代品的功效 阀门技术通过微调材料成分和加工来满足耐用性和抗血栓形成的要求 对心脏瓣膜的要求。我们的中心假设是：带有涡流发生器的超全能 BMHV 控制技术将在血流动力学性能、血液损伤和 血液-材料表面相容性，同时表现出令人满意的耐久性。这是在两个目标上进行测试的。目标1 使用 VG BMHV 量化 SO 的心脏瓣膜血流动力学性能，以确定理想的 SO+VG 具有卓越的血流动力学和最小的血液损伤的配置。目标 2 侧重于阐明影响 小叶成分和加工对血液相容性的影响，同时优化强度和血液相容性 的涂层。该提案由 Lakshmi Prasad Dasi 博士领导，他是一位训练有素的年轻研究员， 心脏瓣膜工程和心血管生物力学方面的专业知识，多个心脏瓣膜的发明者 技术包括 VG 和新型生物分子聚合物小叶。多位 PI 是 Kota 博士，他是一位知名人士 超疏水材料专家； Popat 博士的专长在于生物相容性和表面 纳米工程。如果拟议的工作表明 SO 与 VG BMHV 能产生出色的血流动力学， 而且耐用，这项 R21 资助可能会带来机械 HV 和所有其他血液技术的突破 需要很少或不需要抗凝的接触装置（例如人工心脏、LVAD 等）。

项目成果

Tanfloc/heparin polyelectrolyte multilayers improve osteogenic differentiation of adipose-derived stem cells on titania nanotube surfaces.

• DOI: 10.1016/j.carbpol.2020.117079
• 发表时间: 2021-01-01
• 期刊: Carbohydrate polymers
• 影响因子: 11.2
• 作者: Sabino RM;Mondini G;Kipper MJ;Martins AF;Popat KC
• 通讯作者: Popat KC

On-demand, remote and lossless manipulation of biofluid droplets.

• DOI: 10.1039/d2mh00695b
• 发表时间: 2022-10-31
• 期刊: Materials horizons
• 影响因子: 13.3

Hydrothermally treated titanium surfaces for enhanced osteogenic differentiation of adipose derived stem cells.

• DOI: 10.1016/j.msec.2021.112315
• 发表时间: 2021-09
• 期刊: Materials science & engineering. C, Materials for biological applications
• 作者: Manivasagam VK;Popat KC
• 通讯作者: Popat KC

Controlling the Flow Separation in Heart Valves Using Vortex Generators.

使用涡流发生器控制心脏瓣膜中的流动分离。

• DOI: 10.1007/s10439-022-02966-5
• 发表时间: 2022
• 期刊: Annals of biomedical engineering
• 影响因子: 3.8
• 作者: Wang,Zhenyu;Dasi,LakshmiPrasad;Hatoum,Hoda
• 通讯作者: Hatoum,Hoda

Fetal Transcatheter Trileaflet Heart Valve Hemodynamics: Implications of Scaling on Valve Mechanics and Turbulence.

胎儿经导管三叶心脏瓣膜血流动力学：缩放对瓣膜力学和湍流的影响。

• DOI: 10.1007/s10439-020-02475-3
• 发表时间: 2020
• 期刊: Annals of biomedical engineering
• 影响因子: 3.8
• 作者: Hatoum,Hoda;Gooden,Shelley;Heitkemper,Megan;Blum,KevinM;Zakko,Jason;Bocks,Martin;Yi,Tai;Wu,Yen-Lin;Wang,Yadong;Breuer,ChristopherK;Dasi,LakshmiPrasad
• 通讯作者: Dasi,LakshmiPrasad