Statistical Models for Genetic Studies, Using Network and Integrative Analysis
Statistical Models for Genetic Studies, Using Network and Integrative Analysis
批准号:
10134596
负责人:
Dongjun Chung
金额:
$25.79万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
已结题
起止时间:
2016-07-21 至 2021-04-30
中文摘要
全基因组关联研究已经确定了数以万计的相关遗传变异。
有数百种表型和疾病,在某些情况下提供了临床和医疗益处
给拥有新生物标记物和治疗靶点的患者。然而,对复杂性状的研究往往
由于多基因、高维和中等样本量,统计能力有限。而当
招募患者以获得足够的样本量来识别所有相关的患者实际上是具有挑战性的,而且成本高昂。
基因变异,我们最近表明,识别风险相关基因变异的统计能力可以是
显著提高了1)考虑到多个表型之间共享的遗传基础,即多效性,
2)整合基因组和遗传注释数据。然而,这些数据集的有效集成
随着基因研究和注释数据的增加,在统计上变得更具挑战性。
这项建议的目标是开发统计方法和软件,以改进识别和
解释风险变异并促进对表型间遗传关系的理解。这
目标将通过追求四个具体目标来实现。在目标1中,我们将开发一个贝叶斯图形模型
为了识别风险变量并构建表型网络,通过将多个GWAS数据集与不同的
注释数据。在目标2中,我们将开发一个贝叶斯图形模型来构建表型网络
生物医学文献。在目标3中,我们将开发一种统计方法来构建元注释,该方法可以
有效地汇总高维批注数据,而不会失去可解释性。在目标4中,我们将应用
这些方法用于非裔美国人血管并发症和自身免疫性疾病的遗传学研究
人口,包括PubMed文献和各种注释数据集。建议的研究具有创新性。
因为它提出了一个新的统计框架,集成了多个GWA、生物医学文献和
注释数据集,以改进对风险变量的识别和解释。拟议的研究是
意义重大,因为它有望以更有效的方式帮助改进疾病的诊断和治疗
确定风险变种,加强对疾病常见病因的了解。
英文摘要
Genome-wide association studies (GWAS) have identified tens of thousands of genetic variants associated
with hundreds of phenotypes and diseases, which in some cases have provided clinical and medical benefits
to patients with novel biomarkers and therapeutic targets. However, investigation of complex traits often
suffers from limited statistical power due to polygenicity, high dimensionality, and moderate sample size. While
it is practically challenging and costly to recruit patients to attain sufficient sample size to identify all associated
genetic variants, we recently showed that statistical power to identify risk associated genetic variants can be
significantly increased by 1) considering genetic basis shared among multiple phenotypes, namely pleiotropy,
and 2) incorporating genomic and genetic annotation data. However, effective integration of these datasets
becomes statistically more challenging as the number of genetic studies and annotation data increases.
The objective of this proposal is to develop statistical methods and software to improve identification and
interpretation of risk variants and to promote understanding of genetic relationship among phenotypes. This
objective will be attained by pursuing four specific aims. In Aim 1, we will develop a Bayesian graphical model
to identify risk variants and construct a phenotype network, by integrating multiple GWAS datasets with various
annotation data. In Aim 2, we will develop a Bayesian graphical model to build a phenotype network from
biomedical literature. In Aim 3, we will develop a statistical method to construct meta-annotations that can
effectively summarize high dimensional annotation data without losing interpretability. In Aim 4, we will apply
these methods to genetic studies of vascular complications and autoimmune diseases in African American
populations, with PubMed literature and various annotation datasets. The proposed research is innovative
because it proposes a novel statistical framework that integrates multiple GWAS, biomedical literature, and
annotation datasets to improve identification and interpretation of risk variants. The proposed research is
significant because it is expected to help improve diagnosis and treatment of diseases with more effective
identification of risk variants and enhanced understanding of common etiology among diseases.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Statistical Power Calculation Framework for Spatially Resolved Transcriptomics Experiments
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批准号:10629262
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项目类别:
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资助金额:$23.0万
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财政年份:2022
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负责人:Dongjun Chung
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依托单位:
Statistical Power Calculation Framework for Spatially Resolved Transcriptomics Experiments
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批准号:10453133
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项目类别:
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资助金额:$19.15万
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财政年份:2022
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负责人:Dongjun Chung
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依托单位:
The Genetic Basis of Opioid Dependence Vulnerablility in a Rodent Model
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批准号:10454143
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项目类别:
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资助金额:$78.26万
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财政年份:2018
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负责人:Dongjun Chung
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依托单位:
The Genetic Basis of Opioid Dependence Vulnerablility in a Rodent Model
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批准号:9982281
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项目类别:
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资助金额:$85.24万
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财政年份:2018
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负责人:Dongjun Chung
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依托单位:
The Genetic Basis of Opioid Dependence Vulnerablility in a Rodent Model
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批准号:10223254
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项目类别:
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资助金额:$92.18万
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财政年份:2018
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负责人:Dongjun Chung
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依托单位:
The Genetic Basis of Opioid Dependence Vulnerablility in a Rodent Model
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批准号:9788389
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项目类别:
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资助金额:$77.16万
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财政年份:2018
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负责人:Dongjun Chung
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依托单位:
Statistical Models for Genetic Studies, Using Network and Integrative Analysis
-
批准号:9920162
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项目类别:
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资助金额:$33.28万
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财政年份:2016
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负责人:Dongjun Chung
-
依托单位:
国内基金
海外基金
Scalable Learning and Optimization: High-dimensional Models and Online Decision-Making Strategies for Big Data Analysis
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批准号:--
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项目类别:合作创新研究团队
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资助金额:--
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批准年份:2024
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负责人:姚韬
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依托单位:
新型手性NAD(P)H Models合成及生化模拟
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批准号:20472090
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项目类别:面上项目
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资助金额:23.0万元
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批准年份:2004
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负责人:王乃兴
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依托单位: