Recording gaze-corrected electroretinograms using eye-tracking

使用眼球追踪记录凝视校正视网膜电图

• 批准号: 10087939
• 负责人: Athanasios Panorgias
• 金额: $ 14.85万
• 依托单位: NEW ENGLAND COLLEGE OF OPTOMETRY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-01 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10087939
• 关键词: Address; Adult; Age; Age related macular degeneration; Area; Basic Science; Behavioral; Blindness; Clinical Research; Computer software; Data; Development; Diagnostic; Disease; Disease Progression; Early Diagnosis; Early treatment; Electrophysiology (science); Electroretinography; Emotional; Equipment; Eye; Eye Movements; Foundations; Functional Imaging; Future; Genetic; Image; Intervention; Location; Maps; Measures; Medical; Methods; Modality; Monitor; Natural History; Neurosciences; Noise; Nonexudative age-related macular degeneration; Occupations; Office Visits; Operative Surgical Procedures; Optical Coherence Tomography; Pathology; Pharmacologic Substance; Population; Positioning Attribute; Prevention; Prognosis; Publications; Resolution; Retina; Retinal Diseases; Signal Transduction; Specificity; Stimulus; Structure; System; Techniques; Technology; Testing; Time; To specify; Treatment Cost; United States; Vision; Vision research; Visual; Visual system structure; Wages; adaptive optics; adaptive optics scanning laser ophthalmoscopy; experience; experimental study; functional gain; gaze; geographic atrophy; imaging modality; imaging system; in vivo; interest; macula; response; retinal imaging; stem cell therapy; vision aid; visual tracking

Project Summary/Abstract People living in the United States with a retinal disease account for ~12 million. Visual disturbances are some of the most common, bothersome and debilitating consequences of retinal pathology, that can result in blindness. Studies of retinal diseases in vivo offer a plethora of information that is used to guide treatments, interventions, and eventually prevention. Currently, the structural consequences of these diseases can be assessed with unprecedented resolution at the cellular level, and over the past few decades, this information led to a better understanding of their natural history. The manifestation of a disease always has a structural and a functional component, and to date, there are no methods for measuring retinal function objectively at a high spatial resolution and high spatial accuracy. While several methods have been successfully developed for correcting for eye movements in retinal imaging modalities, little effort has been dedicated on correcting for eye movements in retinal functional modalities, like the multifocal electroretinogram (ERG). With this proposal, we aim to develop a system using eye-tracking technology and electrophysiological equipment to avoid spatial averaging during ERG recordings and at the same time achieve high retinal spatial accuracy. We will interface an eye-tracker with a display to create a gaze-contingent display while we record ERGs and eye-movements at the same time. By having eye movement data throughout the recording, we will also be able to correct for gaze location offline. The experiments we propose will also test the spatial resolution limits we can achieve with electrophysiological means, and we will use these data to create a high-resolution, high-accuracy functional map of the retina. The developed methods could then be used in basic and clinical research for a plethora of retinal diseases, or for answering neuroscience questions. The high resolution and accuracy ERGs can be performed to study disease progression at specific retinal locations, to examine the disease front like the geographic atrophy in advanced dry age-related macular degeneration and other debilitating retinal pathologies. This proposal addresses needs identified in the NEI Publication “Vision Research: Needs, Gaps, and Opportunities”: “Characterize the macula and perifoveal regions of the retina to better understand the predilection of the macula for disease.”

项目摘要/摘要 生活在美国的视网膜疾病患者约为1200万。视觉障碍是一些 视网膜病理最常见、最烦人、最令人衰弱的后果之一，可能会导致 失明。对视网膜疾病的活体研究提供了大量用于指导治疗的信息， 干预，并最终预防。目前，这些疾病的结构性后果可能是 在细胞水平上以前所未有的分辨率进行评估，在过去的几十年里，这些信息导致 更好地了解他们的自然历史。 一种疾病的表现总是有结构和功能的组成部分，到目前为止， 目前还没有在高空间分辨率和高空间精度下客观测量视网膜功能的方法。 虽然已经成功地开发了几种方法来校正视网膜成像中的眼动 在矫正视网膜功能模式中的眼球运动方面，几乎没有专门的努力， 比如多焦视网膜电流图(ERG)。 有了这个提议，我们的目标是开发一种使用眼球跟踪技术和电生理的系统 在ERG记录过程中避免空间平均的设备，同时实现高视网膜空间 精确度。我们将把一个眼球跟踪器和一个显示器连接起来，在我们录制的同时创建一个视线相关的显示 ERGS和眼球运动同时进行。通过在整个记录过程中使用眼动数据，我们将 还可以离线校正凝视位置。我们提出的实验也将测试空间分辨率 我们可以用电生理手段达到的极限，我们将使用这些数据来创造一个高分辨率， 高精度的视网膜功能图。 所开发的方法可用于视网膜过多的基础和临床研究。 疾病，或回答神经科学问题。高分辨率和高精度的ERG可用于 研究特定视网膜位置的疾病进展，以检查疾病前沿，如地理萎缩 在晚期干性老年性黄斑变性和其他衰弱的视网膜病变中。这项建议 满足NEI出版物《愿景研究：需求、差距和机遇》中确定的需求： 描述视网膜的黄斑和黄斑周围区域的特征，以更好地了解 用来治病的黄斑。“