C-di-AMP signaling in S. aureus
金黄色葡萄球菌中的 C-di-AMP 信号传导
基本信息
- 批准号:10089215
- 负责人:
- 金额:$ 54.86万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-02-01 至 2024-01-31
- 项目状态:已结题
- 来源:
- 关键词:AdolescentAntibiotic ResistanceAntibiotic TherapyAntibiotic susceptibilityBacteriaBacterial InfectionsBacterial PhysiologyBindingBiochemicalCellsCessation of lifeChronicCladribineClinicalCystic FibrosisDiseaseDisease ProgressionEnzymesExhibitsGammaproteobacteriaGene Expression RegulationGrowthHuman GeneticsImmune System DiseasesImmunityInfectionInfectious Skin DiseasesInflammationInflammatoryInfluenzaInterferon-betaInterferonsLaboratoriesLinkLongitudinal cohortLung infectionsMediatingMediator of activation proteinMetabolismModelingMolecularMonitorMorbidity - disease rateMulti-Drug ResistanceMusNucleotidesOrganismOutcomePathogenesisPathologicPathologyPeriodicityPhenotypePhysiologyPneumoniaPredispositionProcessProductionProteinsProteobacteriaPseudomonas aeruginosaPulmonary FibrosisRoleSecond Messenger SystemsSignal TransductionSignaling MoleculeSkin TissueSoft Tissue InfectionsStaphylococcus aureusStaphylococcus aureus infectionStudy modelsSurgical Wound InfectionTestingTherapeutic InterventionThymidineTissuesVariantVirulenceWound Infectionacute infectionbasecell behaviorchronic infectionchronic woundco-infectioncystic fibrosis patientsenvironmental changegenetic associationhuman diseasehuman morbidityhuman mortalityimmune activationin vivoinsightmortalitynew therapeutic targetnovelpulmonary function declinereceptorresponsesoft tissuesuperinfectionthymidylate kinasetissue culture
项目摘要
Abstract
Staphylococcus aureus is a leading cause of human morbidity and mortality, causing infection of
the skin and soft tissues, post-surgical wounds, and lung infection among influenza and cystic
fibrosis patients. Widespread multi-drug resistance has made eradication of S. aureus
increasingly challenging, necessitating a deeper understanding of the physiology and
pathogenesis associated with these organisms. A key aspect of bacterial survival and adaptation
to altered environmental conditions is the ability to rapidly alter cellular behavior through second
messenger signal transduction. C-di-AMP has recently emerged as a key regulator of bacterial
physiology, pathogenesis, and immune activation. In the context of S. aureus, we believe that c-
di-AMP produced by S. aureus has three important roles; (i) as a signaling molecule that mediates
S. aureus metabolism and antibiotic resistance, (ii) as a bacterial PAMP that promotes
pathological inflammation and host susceptibility to bacterial infection, and (iii) as a mediator of
inter-bacterial signaling that alters the outcome of co-infections. Findings from these studies may
have significant impacts on the course of antibiotic therapy during S. aureus infection and may
uncover a novel target to eradicate recalcitrant S. aureus and the inflammation itpromotes.
摘要
金黄色葡萄球菌(Staphylococcus aureus)是人类发病率和死亡率的主要原因,其引起细菌感染。
皮肤和软组织,手术后伤口,以及流感和囊性肺炎中的肺部感染
纤维化患者广泛存在的多重耐药使得根除沙门氏菌成为可能。金黄色
越来越具有挑战性,需要更深入地了解生理学,
与这些生物体有关的致病机制。细菌生存和适应的一个关键方面
改变环境条件的能力是通过第二次快速改变细胞行为的能力,
信使信号转导C-di-AMP最近已成为细菌生长的关键调节剂,
生理学、发病机理和免疫激活。在S. aureus我们相信c-
二磷酸腺苷(di-AMP)是S.金黄色葡萄球菌有三个重要作用:(i)作为一种信号分子,
S.金黄色葡萄球菌代谢和抗生素抗性,(ii)作为细菌PAMP,促进
病理性炎症和宿主对细菌感染的易感性,和(iii)作为
细菌间的信号传导改变了合并感染的结果。这些研究的结果可能
对S.金黄色葡萄球菌感染,
发现了一个新的目标,以消除柠檬酸S。金黄色葡萄球菌及其引发的炎症。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Joshua Woodward其他文献
Joshua Woodward的其他文献
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{{ truncateString('Joshua Woodward', 18)}}的其他基金
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- 资助金额:
$ 54.86万 - 项目类别:
Kvbeta2 and the host response to cyclic dinucleotides
Kvbeta2 和宿主对环状二核苷酸的反应
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FRET based imaging of cyclic dinucleotide dynamics in living systems
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10038738 - 财政年份:2020
- 资助金额:
$ 54.86万 - 项目类别:
FRET based imaging of cyclic dinucleotide dynamics in living systems
基于 FRET 的生命系统中环状二核苷酸动力学成像
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10183159 - 财政年份:2020
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The mechanisms of 4-HNE mediated host-microbe interactionsdline
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The mechanisms of 4-HNE mediated host-microbe interactionsdline
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9221802 - 财政年份:2016
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10330555 - 财政年份:2015
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