Y Chromosome Evolution
Y染色体进化
基本信息
- 批准号:10092198
- 负责人:
- 金额:$ 41.39万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-02-01 至 2023-01-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectArchitectureBiologicalCatalogsChickensChromosomesCodeComplementComputational TechniqueComputing MethodologiesCytogeneticsDNA ResequencingDNA Transposable ElementsDataDiseaseEvolutionFemaleFertilityGene DosageGene FamilyGenesGenetic DriftGenetic MarkersGenomeGenomicsGoalsGorilla gorillaHaploidyHumanIndividualInvestigationMale InfertilityMethodsModelingMultigene FamilyNaturePan GenusPan paniscusPartner in relationshipPatternPhylogenetic AnalysisPhylogenyPongidaePongo pygmaeusPopulationPopulation SizesProcessProteinsPublishingResearchResearch PersonnelResourcesSex ChromosomesShapesSpermatogenesisStructureSystemTechniquesTestingTestisTheoretical modelTranscriptY ChromosomeY proteinautosomebasedesigndigitaldiverse datahuman maleinterestmalemale fertilitymammalian genomenovelprototyperapid techniquesexsex determinationsimulationsperm celltraittranscriptome
项目摘要
PROJECT SUMMARY
The male-specific Y chromosome is critical for sex determination and fertility. Yet, because of its highly
repetitive structure and haploidy, its sequence has only been deciphered for a handful of mammalian species,
including just three apes ‒ human, chimpanzee, and gorilla. The lack of Y chromosome sequences has made it
difficult to obtain a complete picture of mammalian genome evolution, and has hampered studies of sex-
specific dynamics in natural populations. In this project, we have chosen to study evolution of ape Y
chromosomes because they differ enormously among species at the cytogenetic level, and because mating and
dispersal patterns, which influence selection and genetic drift acting on the Y, vary dramatically among apes.
Our goal is to decipher the evolutionary processes shaping ape Y chromosome evolution by examining Y
interspecific divergence and intraspecific diversity. In Aim 1 we will study evolution of ape Y chromosome
architecture. Applying our novel method based on the latest experimental and computational techniques, we
assembled the Y chromosomes of gorilla, bonobo, and Bornean orangutan. Using these and publicly available
ape Y assemblies in a phylogenetic framework, we will study several features of Y chromosome architecture:
sequence divergence, gene content, and transposable element accumulation. Instances of lineage-specific
accelerated or decelerated evolution of Y chromosome evolution will be identified and their causes will be
explored in subsequent aims. In Aim 2 we will investigate evolutionary forces affecting global Y chromosome
architecture by studying Y chromosome diversity. We will test whether the observed diversity patterns, as
inferred from publicly available and in-house generated re-sequencing data, are consistent with random
genetic drift or with positive or negative selection. In Aims 3 and 4, the selection targets will be identified. In
Aim 3, we will decipher the individual gene sequences from short- and long-read transcriptome assemblies,
construct gene phylogenies, and test for lineage-specific selection acting on individual genes and on individual
gene copies for multi-copy gene families. Aim 4 will evaluate potential selection acting on the expression
levels and copy number of multi-copy ampliconic gene families on the Y chromosome. These genes are
expressed during spermatogenesis and their deletions have been implicated in human male infertility. Overall,
our project will have important implications for uncovering the intricacies of ape genome evolution. The ape Y
chromosome assemblies, alignments, and transcript catalogues will serve as an invaluable resource for
addressing a myriad of long-standing biological questions and for designing genetic markers to trace the
dispersal of male apes in the wild. This is critical, as all studied ape species are endangered. The techniques
developed for this project will be shared with other researchers, enabling them to study Y chromosomes of
other species. Our thorough investigation of evolution of ampliconic gene sequence, expression levels, and
copy number will significantly contribute to our understanding of the causes of male infertility.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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KATERYNA MAKOVA其他文献
KATERYNA MAKOVA的其他文献
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{{ truncateString('KATERYNA MAKOVA', 18)}}的其他基金
The impact of G-quadruplexes on genome evolution
G-四链体对基因组进化的影响
- 批准号:
10548899 - 财政年份:2021
- 资助金额:
$ 41.39万 - 项目类别:
The impact of G-quadruplexes on genome evolution
G-四链体对基因组进化的影响
- 批准号:
10319020 - 财政年份:2021
- 资助金额:
$ 41.39万 - 项目类别:
Male Mutation Bias and Paternal Age Effect in Mammals
哺乳动物中的雄性突变偏差和父亲年龄效应
- 批准号:
7913976 - 财政年份:2009
- 资助金额:
$ 41.39万 - 项目类别:
Male Mutation Bias and Paternal Age Effect in Mammals
哺乳动物中的雄性突变偏差和父亲年龄效应
- 批准号:
6825563 - 财政年份:2004
- 资助金额:
$ 41.39万 - 项目类别:
Male Mutation Bias and Paternal Age Effect in Mammals
哺乳动物中的雄性突变偏差和父亲年龄效应
- 批准号:
7241573 - 财政年份:2004
- 资助金额:
$ 41.39万 - 项目类别:
Male Mutation Bias and Paternal Age Effect in Mammals
哺乳动物中的雄性突变偏差和父亲年龄效应
- 批准号:
7455059 - 财政年份:2004
- 资助金额:
$ 41.39万 - 项目类别:
Male Mutation Bias and Paternal Age Effect in Mammals
哺乳动物中的雄性突变偏差和父亲年龄效应
- 批准号:
7075345 - 财政年份:2004
- 资助金额:
$ 41.39万 - 项目类别:
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