Identifying the Distribution, Origin, and Threat of Plasmodium vivax in the DRC

确定刚果民主共和国间日疟原虫的分布、来源和威胁

• 批准号: 10092922
• 负责人: Nicholas Ford Brazeau
• 金额: $ 4.96万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-01 至 2023-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10092922
• 关键词: Adult; Africa South of the Sahara; African; Behavioral; Behavioral Genetics; Blood specimen; Child; Country; Data; Data Analyses; Data Set; Democratic Republic of the Congo; Demographic and Health Surveys; Epidemiology; Factor Analysis; Genetic; Geographic Distribution; Geography; Goals; High Prevalence; Incidence; Individual; Infection; Infectious Disease Epidemiology; International; Intervention; Knowledge; Malaria; Maps; Measures; Medicine; Modeling; Morbidity - disease rate; Mutation; Parasites; Phenotype; Physicians; Plasmodium falciparum; Plasmodium vivax; Population; Population Genetics; Population Study; Postdoctoral Fellow; Prevalence; Public Health; Recording of previous events; Reporting; Research; Research Proposals; Risk Factors; Sampling; Scientist; Source; Surveys; Time; Training; Treatment Protocols; Vivax Malaria; Woman; base; disability-adjusted life years; epidemiology study; genetic approach; genome sequencing; genomic epidemiology; identity by descent; individualized medicine; infection risk; innovation; men; mortality; multilevel analysis; novel; pathogen; programs; screening; skills; statistics; transmission process; vector mosquito; whole genome

Project Abstract Malaria due to Plasmodium vivax causes significant global morbidity and even mortality each year. However, it has long been considered absent from Sub-Saharan Africa due to the high prevalence of a mutation that confers the Duffy-negative phenotype and protects the host from infection. Although the Duffy-negative phenotype has been previously shown to be protective, recent reports from Sub-Saharan Africa have identified active transmission of P. vivax among Duffy-negative hosts. This indication that P. vivax can infect Duffy- negative hosts raises several questions, including where are infections occurring, who is being infected, where are these infections being sourced from, and finally, the history and extent of ongoing transmission. The objective of this proposal is to fill this critical gap in knowledge and provide public health officials with the information needed to form strategies for targeted interventions. In this proposal, we will use data collected by the Demographic Health Survey (DHS) during the 2013-2014 Standard DHS Survey of the Democratic Republic of the Congo (Study ID: DRC DHS-II). This nationally representative survey included approximately 25,000 adult men, women, and children across the DRC. From each individual, we have over 500 demographic and behavioral covariates, P. vivax malaria status, and geographical information. Using this robust dataset, the Specific Aims of this proposal are: (1) Map P. vivax prevalence and identify risk factors associated with infection in the Democratic Republic of the Congo using the 2013-2014 Demographic Health Survey and (2) Using whole genome sequencing, identify the source of infection and determine the extent of ongoing transmission among the Democratic Republic of the Congo P. vivax population. Through this research proposal and associated training plan, I will gain a unique and interdisciplinary skill-set that combines epidemiology with population genetics in an innovative manner that is at the forefront of infectious disease epidemiology. This training will provide me with the technical, statistical, and professional skills I need to become a leader at an academic center and to pursue my goals of practicing international medicine and research as a physician scientist.

项目摘要 由间日疟原虫引起的疟疾每年在全球引起严重的发病率甚至死亡率。但 长期以来，由于一种突变的高流行率， 赋予达菲阴性表型并保护宿主免受感染。虽然达菲阴性 表型先前已被证明是保护性的，最近来自撒哈拉以南非洲的报告已经确定， 间日疟原虫在达菲阴性宿主中的主动传播。这表明间日疟原虫可以感染达菲- 阴性宿主提出了几个问题，包括感染发生在哪里，谁被感染， 这些感染的来源是什么，最后是持续传播的历史和程度。的 该提案的目的是填补这一关键的知识空白，并为公共卫生官员提供 制定有针对性的干预战略所需的信息。 在本提案中，我们将使用2013-2014年人口健康调查（DHS）收集的数据。 刚果民主共和国标准DHS调查（研究编号：DRC DHS-II）。这个国家 代表性调查包括刚果民主共和国各地约25，000名成年男子、妇女和儿童。从 每个人，我们有超过500个人口统计学和行为协变量，间日疟原虫疟疾状态， 地理信息。利用这个强大的数据集，本建议的具体目标是：（1）地图P. vivax 在刚果民主共和国， 使用2013-2014年人口健康调查和（2）使用全基因组测序，确定 确定感染源，并确定刚果民主共和国 刚果间日疟原虫种群的数量 通过这项研究计划和相关的培训计划，我将获得一个独特的和跨学科的技能， 它以创新的方式将流行病学与群体遗传学相结合， 传染病流行病学这次培训将为我提供技术，统计和专业知识。 我需要成为一个学术中心的领导者，并追求我的国际实践目标 医学和研究作为一个医生科学家。