权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Theory and methods for mediation and interaction

调解和互动的理论和方法

基本信息

批准号：
10092817
负责人：
Eric Joel Tchetgen Tchetgen
金额：
$ 44.72万
依托单位：
HARVARD SCHOOL OF PUBLIC HEALTH
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-02-19 至 2023-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10092817
关键词：
Arsenic Bangladesh Cardiovascular Diseases Characteristics Colorectal Cancer Complex Data Set Disease Disease Outcome Environment Environmental Exposure Environmental Risk Factor Etiology Event Exposure to Framingham Heart Study Genes Genetic Grant Health Health Professional Heritability Heterogeneity Hyperkeratosis Individual Longitudinal Studies Malignant Neoplasms Mediating Mediation Mediator of activation protein Melanosis Methodology Methods Modeling Molecular Nurses&apos Health Study Outcome Pathway interactions Prevention Prevention strategy Preventive Process Prognosis Research Role Time Treatment Effectiveness cancer subtypes disorder subtype effective therapy exposure pathway gene environment interaction gene interaction improved individualized medicine insight malignant breast neoplasm molecular pathology novel personalized medicine preventive intervention skin lesion skin organogenesis theories tool trait treatment strategy tumor

项目摘要

Project Summary The proposed research will develop novel methods to assess mediation and interaction between genetic and environmental exposures and different disease subtypes so as to better tailor treatments and prevention efforts to individuals' characteristics and so as to better understand the mechanisms governing disease. Methods will be developed for settings in which there are multiple disease subtypes and these disease subtypes may have different prognosis for survival and may be more amenable to different types of treatment and preventive efforts. Methodology for assessing the role of interaction in understanding mechanisms will also be developed. This will include elucidating the role of gene-environment interaction in the heritability of disease, understanding mediating pathways from exposure to disease in the presence of interaction, and identifying sufficient cause interaction for diseases or disease subtypes such that an outcome would occur if two (or more) exposures are present, but not if only one or the other were present. The methodology will be applied to understand prognosis, treatment decisions, preventive interventions, and mechanisms for colorectal cancer, and also for the development of skin lesions; the methodology will also be applied to understand the role of gene-environment interaction in the heritability of numerous traits.

项目摘要拟议的研究将开发新的方法来评估遗传和基因之间的中介和相互作用。环境暴露和不同的疾病亚型，以便更好地调整治疗和预防工作以更好地了解控制疾病的机制。方法将开发用于存在多种疾病亚型的环境，这些疾病亚型可能具有不同的生存预后，可能更适合不同类型的治疗和预防努力还将制定评估互动在理解机制方面的作用的方法。这将包括阐明基因-环境相互作用在疾病遗传性中的作用，了解在存在相互作用的情况下从暴露到疾病的介导途径，并确定疾病或疾病亚型的充分原因相互作用，如果两种（或多种）暴露是存在的，但如果只有一个或另一个存在。该方法将应用于了解结直肠癌的预后，治疗决策，预防干预和机制，以及皮肤病变的发展;该方法也将应用于了解许多性状的遗传力的基因-环境交互作用。