Theory and methods for mediation and interaction

调解和互动的理论和方法

基本信息

项目摘要

Project Summary The proposed research will develop novel methods to assess mediation and interaction between genetic and environmental exposures and different disease subtypes so as to better tailor treatments and prevention efforts to individuals' characteristics and so as to better understand the mechanisms governing disease. Methods will be developed for settings in which there are multiple disease subtypes and these disease subtypes may have different prognosis for survival and may be more amenable to different types of treatment and preventive efforts. Methodology for assessing the role of interaction in understanding mechanisms will also be developed. This will include elucidating the role of gene-environment interaction in the heritability of disease, understanding mediating pathways from exposure to disease in the presence of interaction, and identifying sufficient cause interaction for diseases or disease subtypes such that an outcome would occur if two (or more) exposures are present, but not if only one or the other were present. The methodology will be applied to understand prognosis, treatment decisions, preventive interventions, and mechanisms for colorectal cancer, and also for the development of skin lesions; the methodology will also be applied to understand the role of gene-environment interaction in the heritability of numerous traits.
项目总结

项目成果

期刊论文数量(70)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Efficient estimation of human immunodeficiency virus incidence rate using a pooled cross-sectional cohort study design.
  • DOI:
    10.1002/sim.8661
  • 发表时间:
    2020-10-30
  • 期刊:
  • 影响因子:
    2
  • 作者:
    Molebatsi K;Gabaitiri L;Mokgatlhe L;Moyo S;Gaseitsiwe S;Wirth KE;DeGruttola V;Tchetgen Tchetgen E
  • 通讯作者:
    Tchetgen Tchetgen E
Commentary: Developing best-practice guidelines for the reporting of E-values.
评论:为电子价值报告制定最佳实践指南。
Generalized Difference-in-Differences.
广义双重差分。
  • DOI:
    10.1097/ede.0000000000001568
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Richardson,DavidB;Ye,Ting;TchetgenTchetgen,EricJ
  • 通讯作者:
    TchetgenTchetgen,EricJ
Causal mediation analysis in the presence of a mismeasured outcome.
存在错误测量结果时的因果中介分析。
  • DOI:
    10.1097/ede.0000000000000204
  • 发表时间:
    2015
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Jiang,Zhichao;VanderWeele,TylerJ
  • 通讯作者:
    VanderWeele,TylerJ
Controversy and debate on credibility ceilings. Paper 3: errors in the statistical justification for the "credibility ceiling" method remain uncorrected.
  • DOI:
    10.1016/j.jclinepi.2020.05.002
  • 发表时间:
    2020-11
  • 期刊:
  • 影响因子:
    7.2
  • 作者:
    Mathur MB;VanderWeele TJ
  • 通讯作者:
    VanderWeele TJ
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Eric Joel Tchetgen Tchetgen其他文献

Eric Joel Tchetgen Tchetgen的其他文献

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{{ truncateString('Eric Joel Tchetgen Tchetgen', 18)}}的其他基金

Novel Designs and Methods to Remove Hidden Confounding Bias in Health Sciences
消除健康科学中隐藏的混杂偏差的新颖设计和方法
  • 批准号:
    10447817
  • 财政年份:
    2020
  • 资助金额:
    $ 43.82万
  • 项目类别:
Novel Designs and Methods to Remove Hidden Confounding Bias in Health Sciences
消除健康科学中隐藏的混杂偏差的新颖设计和方法
  • 批准号:
    10678962
  • 财政年份:
    2020
  • 资助金额:
    $ 43.82万
  • 项目类别:
Novel Designs and Methods to Remove Hidden Confounding Bias in Health Sciences
消除健康科学中隐藏的混杂偏差的新颖设计和方法
  • 批准号:
    10159821
  • 财政年份:
    2020
  • 资助金额:
    $ 43.82万
  • 项目类别:
Theory and methods for mediation and interaction
调解和互动的理论和方法
  • 批准号:
    10092817
  • 财政年份:
    2018
  • 资助金额:
    $ 43.82万
  • 项目类别:
Next Generation Missing Data Methods in HIV Research
HIV 研究中的下一代缺失数据方法
  • 批准号:
    9636187
  • 财政年份:
    2017
  • 资助金额:
    $ 43.82万
  • 项目类别:
Next Generation Missing Data Methods in HIV Research
HIV 研究中的下一代缺失数据方法
  • 批准号:
    10092901
  • 财政年份:
    2017
  • 资助金额:
    $ 43.82万
  • 项目类别:
Semiparametric Methods for Gene-environment Interaction
基因-环境相互作用的半参数方法
  • 批准号:
    8663257
  • 财政年份:
    2012
  • 资助金额:
    $ 43.82万
  • 项目类别:
Semiparametric Methods for Gene-environment Interaction
基因-环境相互作用的半参数方法
  • 批准号:
    8512724
  • 财政年份:
    2012
  • 资助金额:
    $ 43.82万
  • 项目类别:
Semiparametric Methods for Gene-environment Interaction
基因-环境相互作用的半参数方法
  • 批准号:
    8295644
  • 财政年份:
    2012
  • 资助金额:
    $ 43.82万
  • 项目类别:
Semiparametric Methods for Secondary Outcomes in Case-control Studies
病例对照研究中次要结果的半参数方法
  • 批准号:
    8214692
  • 财政年份:
    2011
  • 资助金额:
    $ 43.82万
  • 项目类别:

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