Cancer Genomics Shared Resource

癌症基因组学共享资源 项目摘要 下一代测序(NGS)和微阵列技术是研究 癌症形成、进展和临床结果的基因组和分子基础。初级阶段 癌症基因组学共享资源(CGSR)的目标是最大限度地提高癌症的科学和临床影响 由维克森林浸信会综合癌症中心(WFBCCC)成员进行的研究。这就完成了 通过提供对最先进的基因组技术的快速且经济高效的访问，同时创建一个统一的 培养科学意识、教育和协作的环境。CGSR支持 WFBCCC的使命是为癌症优先提供全面的微阵列和NGS 技术，并提供到生物统计和生物信息学共享资源的无缝数据流- 为生物信息学提供支持。2014年10月，在帕什主任的怂恿下，前微阵列核心 实验室(2002-2014；在先前的评论中获得了“优秀”的分数)被重新命名为癌症 基因组学共享资源反映WFBCCC的微阵列核心能力与 基因组学和个性化医学研究中心的NGS专业知识。这个新的联合中心 伙伴关系反映了WFBCCC和维克森林医学院(WFSOM)的战略计划，如 以及支持WFSOM中心和核心咨询委员会的优先建议。这个 CGSR提供尖端基因组服务，优先考虑针对癌症的研究，创造最佳 为研究所快速发展的精准医学倡议提供环境，并与 WFBCCC内的其他关键共享资源，以促进整合的、高质量的癌症工作流程 基因组学研究。CGSR由联席董事兰斯·米勒博士和格雷格·霍金斯博士领导，他们 在癌症基因组研究方面建立了记录，并由四名经验丰富的技术人员(两名 100%努力，一个50%努力，一个5%努力)。生物信息学家每天将30%的精力投入到CGSR上 行动。在最近的拨款年度(14/11/14-10/31/15)，CGSR以80%-90%的全时当量利用率运行，以 为20名调查员提供1144项服务，其中75%为WFBCCC调查员。与以前相比 几年来，CGSR的服务产出翻了一番，针对癌症的服务产出增加了约 50%。CGSR通过生成以下信息来直接促进WFBCCC调查人员的科学成果 高质量和经济高效的数据，将转化为新的发现、出版物、奖励和 批准申请。进一步发展CGSR在支持开发和提高生产力方面的作用 WFBCCC面向疾病的团队和跨共享的无缝工作流的持续开发 预计资源将加强WFBCCC的翻译基因组学倡议。

CANCER GENOMICS SHARED RESOURCE Project Summary Next-generation sequencing (NGS) and microarray technologies are essential resources for investigating the genomic and molecular underpinnings of cancer formation, progression, and clinical outcomes. The primary objective of the Cancer Genomics Shared Resource (CGSR) is to maximize the scientific and clinical impact of research by Wake Forest Baptist Comprehensive Cancer Center (WFBCCC) members. This is accomplished by providing rapid and cost-effective access to state-of-the-art genomic technologies, while creating a unifying environment that cultivates scientific awareness, education, and collaboration. The CGSR supports the WFBCCC's mission by providing cancer-prioritized access to comprehensive microarray and NGS technologies and offers seamless data flow through to the Biostatistics and Bioinformatics Shared Resource - for bioinformatics support. In October 2014, at the instigation of Director Pasche, the former Microarray Core Laboratory (2002-2014; which received a score of “excellent” in the prior critique) was renamed the Cancer Genomics Shared Resource to reflect the integration of the WFBCCC's microarray core competencies with the NGS expertise of the Center for Genomics and Personalized Medicine Research. This new joint-Center partnership reflects the strategic plans of the WFBCCC and the Wake Forest School of Medicine (WFSOM), as well as supporting priority recommendations of the WFSOM Centers and Cores Advisory Committee. The CGSR provides cutting-edge genomic services, prioritizes cancer-specific research, creates an optimal environment for the Institution's rapidly developing precision medicine initiative, and seamlessly integrates with other key Shared Resources within the WFBCCC to promote integrated, high-quality workflows for cancer genomics research. The CGSR is led by Co-Directors Lance Miller, Ph.D., and Greg Hawkins, Ph.D., who have established records in cancer genomics research, and is operated by four experienced technicians (two at 100% effort, one at 50% effort and one at 5% effort). A bioinformatician devotes 30% of effort to CGSR daily operations. In the most recent grant year (11/01/14-10/31/15), the CGSR operated at 80-90% FTE utilization to provide 1,144 services to 20 investigators, 75% of which were WFBCCC investigators. Compared to previous years, the CGSR doubled its service output and increased its cancer-specific service output by approximately 50%. The CGSR directly contributes to the scientific achievements of WFBCCC investigators by generating high-quality and cost-effective data that will translate into new discoveries, publications, grant awards, and grant applications. Further development of CGSR's role in supporting the development and productivity of WFBCCC Disease-Oriented Teams and the continued development of seamless workflows across Shared Resources are expected to enhance translational genomics initiatives at the WFBCCC.