Cancer Genomics Shared Resource

癌症基因组学共享资源

• 批准号: 10092987
• 负责人: Lance David Miller
• 金额: $ 12.59万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-02-01 至 2022-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10092987
• 关键词: Achievement; Advisory Committees; Applications Grants; Area; Award; Awareness; Baptist Church; Bioinformatics; Bioinformatics Shared Resource; Biometry; Cancer Center Support Grant; Clinical; Collaborations; Competence; Comprehensive Cancer Center; Critiques; Data; Dependence; Development; Disease; Doctor of Philosophy; Education; Environment; Etiology; Fostering; Genetic; Genomic medicine; Genomics; Genomics Shared Resource; Goals; Grant; Institution; Interdisciplinary Study; Joints; Laboratories; Malignant Neoplasms; Microarray Analysis; Microarray Shared Resource; Mission; Molecular; Outcome; Output; Precision Medicine Initiative; Process; Productivity; Publications; Recommendation; Records; Research; Research Personnel; Resource Sharing; Resources; Role; Services; Strategic Planning; Technology; Translating; Vision; cancer genomics; cost effective; experience; forest; medical schools; member; next generation sequencing; operation; personalized medicine; precision oncology; translational cancer research; translational genomics

CANCER GENOMICS SHARED RESOURCE Project Summary Next-generation sequencing (NGS) and microarray technologies are essential resources for investigating the genomic and molecular underpinnings of cancer formation, progression, and clinical outcomes. The primary objective of the Cancer Genomics Shared Resource (CGSR) is to maximize the scientific and clinical impact of research by Wake Forest Baptist Comprehensive Cancer Center (WFBCCC) members. This is accomplished by providing rapid and cost-effective access to state-of-the-art genomic technologies, while creating a unifying environment that cultivates scientific awareness, education, and collaboration. The CGSR supports the WFBCCC's mission by providing cancer-prioritized access to comprehensive microarray and NGS technologies and offers seamless data flow through to the Biostatistics and Bioinformatics Shared Resource - for bioinformatics support. In October 2014, at the instigation of Director Pasche, the former Microarray Core Laboratory (2002-2014; which received a score of “excellent” in the prior critique) was renamed the Cancer Genomics Shared Resource to reflect the integration of the WFBCCC's microarray core competencies with the NGS expertise of the Center for Genomics and Personalized Medicine Research. This new joint-Center partnership reflects the strategic plans of the WFBCCC and the Wake Forest School of Medicine (WFSOM), as well as supporting priority recommendations of the WFSOM Centers and Cores Advisory Committee. The CGSR provides cutting-edge genomic services, prioritizes cancer-specific research, creates an optimal environment for the Institution's rapidly developing precision medicine initiative, and seamlessly integrates with other key Shared Resources within the WFBCCC to promote integrated, high-quality workflows for cancer genomics research. The CGSR is led by Co-Directors Lance Miller, Ph.D., and Greg Hawkins, Ph.D., who have established records in cancer genomics research, and is operated by four experienced technicians (two at 100% effort, one at 50% effort and one at 5% effort). A bioinformatician devotes 30% of effort to CGSR daily operations. In the most recent grant year (11/01/14-10/31/15), the CGSR operated at 80-90% FTE utilization to provide 1,144 services to 20 investigators, 75% of which were WFBCCC investigators. Compared to previous years, the CGSR doubled its service output and increased its cancer-specific service output by approximately 50%. The CGSR directly contributes to the scientific achievements of WFBCCC investigators by generating high-quality and cost-effective data that will translate into new discoveries, publications, grant awards, and grant applications. Further development of CGSR's role in supporting the development and productivity of WFBCCC Disease-Oriented Teams and the continued development of seamless workflows across Shared Resources are expected to enhance translational genomics initiatives at the WFBCCC.

癌症基因组学共享资源 项目摘要 下一代测序（NGS）和微阵列技术是研究基因组学的重要资源。 癌症形成、进展和临床结果的基因组和分子基础。主 癌症基因组学共享资源（CGSR）的目标是最大限度地提高科学和临床影响， 维克森林浸信会综合癌症中心（WFBCCC）成员的研究。来实现这一点 通过提供快速和具有成本效益的获取最先进的基因组技术，同时创建一个统一的 培养科学意识、教育和协作的环境。CGSR支持 WFBCCC的使命是为癌症患者提供全面的微阵列和NGS 技术，并提供无缝的数据流，通过生物统计学和生物信息学共享资源- 生物信息学支持。2014年10月，在Pasche主任的鼓动下，前微阵列核心 实验室（2002-2014;在之前的评论中获得了“优秀”的分数）更名为癌症实验室。 基因组学共享资源，以反映WFBCCC的微阵列核心竞争力与 基因组学和个性化医学研究中心的NGS专业知识。这个新的联合中心 伙伴关系反映了WFBCCC和维克森林医学院（WFSOM）的战略计划， 以及支持WFSOM中心和核心咨询委员会的优先建议。的 CGSR提供尖端的基因组服务，优先考虑癌症特异性研究， 该机构的快速发展的精准医疗计划的环境，并无缝集成， WFBCCC内的其他关键共享资源，以促进癌症的综合、高质量工作流程 基因组学研究CGSR由联合主任兰斯米勒博士领导，和格雷格·霍金斯博士谁 在癌症基因组学研究方面建立了记录，并由四名经验丰富的技术人员（两名 在100%的努力，一个在50%的努力和一个在5%的努力）。生物信息学家每天将30%的精力投入到CGSR中 运营在最近的资助年度（11/01/14-10/31/15），CGSR以80-90%的FTE利用率运行， 为20名调查员提供1 144项服务，其中75%是世界粮食理事会气候变化中心的调查员。相比前 年，CGSR的服务产出翻了一番，并将其癌症特异性服务产出增加了约 百分之五十CGSR通过生成以下内容直接有助于WFBCCC研究人员的科学成就： 高质量和具有成本效益的数据，将转化为新的发现，出版物，赠款奖励， 补助金申请。进一步发展CGSR在支持发展和生产力方面的作用 WFBCCC疾病导向团队和跨共享的无缝工作流程的持续发展 预计资源将加强WFBCCC的翻译基因组学倡议。